A Practical Procedure for the Synthesis of Esonarimod, (R,S)‐2‐Acetylthiomethyl‐4‐(4‐methylphenyl)‐4‐oxobutanoic Acid, an Antirheumatic Agent. Part 1.

Abstract

Thioethers Thioethers Q 0580A Practical Procedure for the Synthesis of Esonarimod, (R,S)-2-Acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic Acid, an Antirheumatic Agent. Part 1. -An efficient method for the synthesis of the title compound (V) is reported. In addition, the structures of various by-products are elucidated. -(NOGUCHI*, T.; ONODERA, A.; TOMISAWA, K.; YOKOMORI, S.; Chem.