2008
DOI: 10.1128/aac.01152-07
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A Practical Guide to Measuring Mutation Rates in Antibiotic Resistance

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Cited by 76 publications
(73 citation statements)
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References 32 publications
(33 reference statements)
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“…The process starts at time t = 0 when the wild-type, drugsensitive population reaches a size of exactly N 0 = 1/m, where m denotes the mutation rate per generation at which new mutant cells are produced [that is, we consider only the so-called Luria-Delbrück period (Rosche and Foster 2000;Refsland and Livingston 2005;Pope et al 2008)]. Since N 0 m = 1, the first resistant mutant, and therefore the first clone, appears when t = 0.…”
Section: Resultsmentioning
confidence: 99%
“…The process starts at time t = 0 when the wild-type, drugsensitive population reaches a size of exactly N 0 = 1/m, where m denotes the mutation rate per generation at which new mutant cells are produced [that is, we consider only the so-called Luria-Delbrück period (Rosche and Foster 2000;Refsland and Livingston 2005;Pope et al 2008)]. Since N 0 m = 1, the first resistant mutant, and therefore the first clone, appears when t = 0.…”
Section: Resultsmentioning
confidence: 99%
“…These data show a maximum, or 'sweet spot', for the number of plated mutants that survive antibiotic exposure and grow into colonies (figure 1a). The fraction of the plated culture that gives rise to mutant colonies, also known as the 'mutation frequency' [25], decreases monotonically with increasing cell density (figure 1b). Therefore, the probability of a mutant growing into a colony must also decrease with increasing cell density.…”
Section: Statistical Testsmentioning
confidence: 99%
“…In addition, some small-area and short-duration (<1 h) operations also used antibacterial agents. Thus, the prophylactic medication indications were apparently not strictly mastered (Pope et al, 2008). The misuse of antibacterial agents not only enables the drug resistance of bacteria to develop, but also unnecessarily incurs cost (Maragakis et al, 2008).…”
Section: Indications For Prophylactic Use Of Antibacterial Agentsmentioning
confidence: 99%