A practical approach to familial and hereditary colorectal cancer

Ivanovich, Jennifer; Read, Thomas E.; Ciske, David J.; Kodner, Ira J.; Whelan, Alison

doi:10.1016/s0002-9343(99)00168-0

Cited by 44 publications

(18 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…28 Cases of colorectal cancer (CRC) can be classified into 3 categories: (1) sporadic (no family history), accounting for approximately 60% of all cases; (2) familial (several affected family members), accounting for 30% of cases; and (3) hereditary (caused by defined genetic syndromes), which represents the remainder. 29 Colorectal cancer screening guidelines issued by the American Cancer Society classify these categories as "average," "moderate," and "high risk," respectively.…”

Section: Family History and Colorectal Cancermentioning

confidence: 99%

“…31 Hereditary nonpolyposis colorectal cancer (HNPCC) is another autosomal-dominant condition manifesting as early-onset CRC, as well as other malignancies, involving the endometrium, small bowel, ureter, or renal pelvis. 28 HNPCC accounts for 6% of all colorectal cancers and is not typically preceded by formation of polyps. 32 Persons with HNPCC have a lifetime risk of CRC ranging between 70% and 80%.…”

Section: Family History and Colorectal Cancermentioning

confidence: 99%

See 1 more Smart Citation

Patients with a Family History of Cancer: Identification and Management

Eberl¹,

Sunga²,

Farrell³

et al. 2005

The Journal of the American Board of Family Medicine

View full text Add to dashboard Cite

A family history of certain malignancies, especially breast, ovarian, colorectal, and prostate cancers, can place persons at increased risk of developing these cancers. By constructing a pedigree that includes 3 generations, family physicians can identify patients at increased risk because of family cancer history. Persons at increased cancer risk because of family history warrant a surveillance strategy for early detection.

show abstract

Section: Family History and Colorectal Cancermentioning

confidence: 99%

Section: Family History and Colorectal Cancermentioning

confidence: 99%

Patients with a Family History of Cancer: Identification and Management

Eberl¹,

Sunga²,

Farrell³

et al. 2005

The Journal of the American Board of Family Medicine

View full text Add to dashboard Cite

show abstract

“…In general, colorectal carcinoma is classified into three categories, based on increasing hereditary influence and cancer risk [3]. Sporadic CRC accounts for approximately 60% of patients and comprises patients with no notable family history and, by definition, with no identifiable inherited gene mutation that accelerates cancer development.…”

Section: Epidemiologymentioning

confidence: 99%

“…Colorectal carcinoma (CRC) is generally classified into three categories, based on increasing hereditary influence and cancer risk [3]. Sporadic CRC (60%)…”

Section: Classification Of Crcmentioning

confidence: 99%

784 Clinical applications of molecular profiling of colorectal cancer

Kheirelseid¹,

Miller²,

Chang³

et al. 2010

European Journal of Cancer Supplements

View full text Add to dashboard Cite

“…Colorectal carcinoma (CRC) is generally classified into three categories, based on increasing hereditary influence and cancer risk [1,2] : sporadic CRC (approximately 60% of cases and comprises patients with no notable family history and, by definition, with no identifiable inherited gene mutation that accelerates cancer development), familial CRC (approximately 30% of cases and refers to patients who have at least one blood relative with CRC or an adenoma, but with no specific germline mutation or clear pattern of inheritance), and hereditary CRC syndromes (approximately 10% of cases, which result from inheritance of a single gene mutation in highly penetrant cancer susceptibility genes). Although the last group has the lowest frequency, it has elucidated molecular mechanisms of carcinogenesis applicable to sporadic CRC [3] .…”

Section: Introductionmentioning

confidence: 99%