“…4,19 Typical grading progresses from impaired relaxation, through pseudonormalization, to a restrictive filling pattern, each reflecting increasingly severe diastolic dysfunction (Table 3). 4,14,15,19,25,29 Guidelines for the echocardiographic assessment of diastolic function are based on data from large numbers of patients across a range of clinical contexts undergoing TTE. A demonstrated association between diastolic dysfunction graded by TTE and important outcomes, such as quality of life, development of heart failure and mortality, 4,30,31 supports the validity of this noninvasive method of assessment.…”