A Practical and Inexpensive One‐Pot Synthesis of Bis(indenyl)­dimethyltitanium with Aqueous Workup Procedure

Abstract

Abstract.A simple, reliable, and reproducible procedure for the multigram synthesis of highly pure bis(indenyl)dimethyltitanium is presented. The procedure relies on a one-pot conversion of inexpensive indene, methyllithium, and titanium tetrachloride to [Ind 2 TiMe 2 ] and

Highly flexible synthesis of indenylethylamines as ligand precursors for titanium complexes

“…The reaction takes place by addition of the α-C−H bond of an amine across a C−C double bond and gives access to α-alkylated amines in a single step and with 100 % atom efficiency. Among the various titanium-catalysts, bis(η 5 -indenyl)dimethyltitanium (Ind 2 TiMe 2 ) 12 was found to be an excellent catalyst for the highly regioselective hydroaminoalkylation of 1-alkenes with N-methylanilines (Scheme 1). 5 In addition, the catalyst can be used for corresponding reactions of styrenes 5 5 The reaction mechanism of the titanium-catalyzed hydroaminoalkylation of alkenes has already been studied in detail 6 and it is generally accepted that titanaaziridines are the catalytically active species.…”

Titanium-Catalyzed Intermolecular Hydroaminoalkylation of Terminal Alkynes

“…All chemicals whose synthesis is not described were purchased from commercial sources. Catalysts Ind 2 TiMe 2 , 12 I , 13 II , 3c II-Bu , 3d II-DIPP , 3d and III 3e were synthesized according to literature procedures. All substrates were distilled or recrystallized and degassed (freeze–pump–thaw) prior to use.…”