A practical and green approach towards synthesis of new <i>N</i>-sulfonylimines under ultrasound irradiation

Grib, Ismahene; Bouzina, Abdeslem; Aouf, Nour‐Eddine; Berredjem, Malika

doi:10.1080/10426507.2016.1138306

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…Following our efforts to develop novel methods for acylation [24][25][26][27]12 and in continuation of our investigation on the use of ultrasound irradiation to accelerate reactions [28][29][30] , we describe a novel method for acylation the different amines and sulfonamides with acetic anhydride under ultrasonic irradiation, in absence of solvent and catalyst.…”

Section: Resultsmentioning

confidence: 99%

A Novel and Green Method for N-acylation of Amines and Sulfonamides under Ultrasound Irradiation

Bouasla¹,

Bechlem²,

Belhani³

et al. 2017

Orient. J. Chem

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A facile and versatile method for acylation of structurally diverse amines and sulfonamides under focused ultrasonic irradiation in catalyst-free and solvent-free conditions is reported. There are several advantages to this approach such as simple and easier workup conditions, small amount of time and high yielding. The acylation reaction was carried out with acetic anhydride. All structures of synthesized products have been identified by NMR and mass spectroscopy.

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Section: Resultsmentioning

confidence: 99%

A Novel and Green Method for N-acylation of Amines and Sulfonamides under Ultrasound Irradiation

Bouasla¹,

Bechlem²,

Belhani³

et al. 2017

Orient. J. Chem

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“…Sulfonamides 1 – 5 were easily prepared in good yield (85–97 %), using chlorosulfonyl isocyanate (CSI) that is the suitable available reagent allowing the introduction of a sulfamide moiety. The reaction was carried out by three steps [35,36] …”

Section: Methodsmentioning

confidence: 99%

“…The reaction was carried out by three steps. [35,36] In the first step, to a solution of chlorosulfonyl isocyanate in anhydrous methylene chloride was added a solution of tertbutanol. The reaction takes place for 30 min.…”

Section: Tested Compoundsmentioning

confidence: 99%

Antibacterial, Cytotoxic and Genotoxic Assessment of New Sulfonamide Derivatives

Becheker

Melakhessou

Marref

et al. 2023

Chemistry & Biodiversity

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In the last few years, the interest in sulfonamides has expanded owing to their broad spectrum of biological activities. Their flexible structure turns them into amazing candidates to replace old drugs or develop modern multi‐target agents. In this study, a series of new sulfonamides (sul1‐5) was evaluated, in vitro, for the antibacterial, cytotoxic and genotoxic effects. The antibacterial activity was investigated against 12 clinical and 4 reference strains. Cytotoxic activity was carried out by the brine shrimp bioassay and the genotoxicity was assessed in the Ames test. An interesting antibacterial activity was showed especially against Gram negative strains. The inhibition zones varied between 15 and 30 mm, and the Minimum Inhibitory Concentrations (MIC’s) values between 0.5 and 256 μg/ml. No antibacterial activity was shown with S. aureus isolates. Only Sul1 and Sul4 were active against P. aeruginosa. Compounds Sul1 and Sul2 showed a significant cytotoxicity with LC50 equal to 18.29 and 18 μg/ml respectively, and a genotoxic effect against TA100 and TA1535 Salmonella strains. Only compounds Sul3, Sul4 and Sul5 with an interesting antibacterial activity, no cytotoxicity and no genotoxic effects, could be exploited against resistant pathogens as new drugs.

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Synthesis, X-ray crystallographic study and molecular docking of new α-sulfamidophosphonates: POM analyses of their cytotoxic activity

Bechlem

Aissaoui

Belhani

et al. 2020

Journal of Molecular Structure

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A practical and green approach towards synthesis of new N-sulfonylimines under ultrasound irradiation

Cited by 7 publications

References 26 publications

A Novel and Green Method for N-acylation of Amines and Sulfonamides under Ultrasound Irradiation

A Novel and Green Method for N-acylation of Amines and Sulfonamides under Ultrasound Irradiation

Antibacterial, Cytotoxic and Genotoxic Assessment of New Sulfonamide Derivatives

Synthesis, X-ray crystallographic study and molecular docking of new α-sulfamidophosphonates: POM analyses of their cytotoxic activity

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