A Powerful New Anomalous Monism

Taylor, Henry

doi:10.4324/9781315104706-4

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2022

2024

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Cited by 2 publications

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“…Change-point analysis of GFP intensity traces using an algorithm ( Taylor, 2000 ) implemented in C++ was used to identify the presence and time of steps corresponding to membrane permeabilisation and capsid opening. Step probabilities were calculated non-parametrically using 10,000 bootstrap iterations.…”

Section: Methodsmentioning

confidence: 99%

Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure

Faysal,

Walsh,

Renner

et al. 2024

eLife

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The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use. Here, we investigate the effect of lenacapavir on HIV capsid stability and uncoating. We employ a single particle approach that simultaneously measures capsid content release and lattice persistence. We demonstrate that lenacapavir’s potent antiviral activity is predominantly due to lethal hyperstabilisation of the capsid lattice and resultant loss of compartmentalisation. This study highlights that disrupting capsid metastability is a powerful strategy for the development of novel antivirals.

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Section: Methodsmentioning

confidence: 99%