A potentiostat circuit for multiple implantable electrochemical sensors

Islam, Ashraf B.; Haider, Mohammad Rafiqul; Atla, A.; Islam, Syed K.; Croce, Robert A.; Vaddiraju, Santhisagar; Papadimitrakopoulos, Fotios; Jain, F.

doi:10.1109/icelce.2010.5700691

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…Microsized devices capable of maintaining a fixed voltage vs. a reference, and suitable for implantation, have been described by others (Islam et al, 2010). In Figure 3, the current response of a PEDOT:Dex electrode to a cyclic voltammogram can be seen as well as the current response to a rectangular pulse.…”

Section: Discussionmentioning

confidence: 99%

“…One possibility to, with a simple device, imitate the effect of a CV is to exchange the sweep with interchangeable voltage steps, set to the upper and lower vertex potential. Microsized devices capable of maintaining a fixed voltage vs. a reference, and suitable for implantation, have been described by others (Islam et al, 2010 ). In Figure 3 , the current response of a PEDOT:Dex electrode to a cyclic voltammogram can be seen as well as the current response to a rectangular pulse.…”

Section: Discussionmentioning

confidence: 99%

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Anti-inflammatory polymer electrodes for glial scar treatment: bringing the conceptual idea to future results

Asplund

Boehler

2014

Front. Neuroeng.

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Conducting polymer films offer a convenient route for the functionalization of implantable microelectrodes without compromising their performance as excellent recording units. A micron thick coating, deposited on the surface of a regular metallic electrode, can elute anti-inflammatory drugs for the treatment of glial scarring as well as growth factors for the support of surrounding neurons. Electro-activation of the polymer drives the release of the substance and should ideally provide a reliable method for controlling quantity and timing of release. Driving signals in the form of a constant potential (CP), a slow redox sweep or a fast pulse are all represented in literature. Few studies present such release in vivo from actual recording and stimulating microelectronic devices. It is essential to bridge the gap between studies based on release in vitro, and the intended application, which would mean release into living and highly delicate tissue. In the biological setting, signals are limited both by available electronics and by the biological safety. Driving signals must not be harmful to tissue and also not activate the tissue in an uncontrolled manner. This review aims at shedding more light on how to select appropriate driving parameters for the polymer electrodes for the in vivo setting. It brings together information regarding activation thresholds for neurons, as well as injury thresholds, and puts this into context with what is known about efficient driving of release from conducting polymer films.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory polymer electrodes for glial scar treatment: bringing the conceptual idea to future results

Asplund

Boehler

2014

Front. Neuroeng.

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“…A potentiostat has the function of current-to-voltage conversion for a single channel. However, for pA-level current measurements, the conventional solutions suffered from insufficient accuracy [24,25,26] or limited dynamic range [27,28]. Besides, it is necessary to consider the performance differences between the single channel and the readout array.…”

Section: Introductionmentioning

confidence: 99%

A potentiostat readout array for nanopore-based DNA sequencing

Wang,

Jin,

Tang

et al. 2024

IEICE Electron. Express

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Nanopore-based DNA sequencing technology features the advantages of label-free, low-cost, and rapid detection. However, the existing nanopore sequencing readout cell or array for the lower area and power consumption become prohibitive. This brief presents a low noise potentiostat readout array. Based on the five-transistor OPA, the half-shared amplifier reduces the area and power consumption of the cell by about 50%, and shows a good suppression effect on mid-to-high frequency noise in the output channel. As a result, high-throughput is achieved with low noise. The performance of the proposed array channel has been evaluated in 180-nm CMOS process, the inputreferred current transient noise was 2.28 pARMS, the power consumption was 2.2 µW and the unit area was 10×12 µm 2 .

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“…The sensing part is usually a three-electrodes (Working, Reference and Counter Electrodes -WE, RE, CE) cell that interfaces with the electronic readout through a potentiostat [13]. Hence, the potentiostat plays a pivotal role by ensuring a constant potential (∆V ) between RE and WE [14] and by collecting current through CE so that reduction and oxidation occurs on the surface of WE [15]. The cell potential between RE and WE (∆V ) is distinct for each analyte, allowing specific compound recognition while the current through CE permits the quantification of such analyte.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous monitoring of anesthetics and therapeutic compounds with a portable multichannel potentiostat

Stradolini

ElBoshra

Biscontini

et al. 2016

2016 IEEE International Symposium on Circuits and Systems (ISCAS)

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Abstract-As metabolic pathways are highly variable among different patients, then an accurate and continuous monitoring of the personal response to drug treatments is essential especially with critical medications, e.g. anesthetic and anti-cancer cocktails. Currently, for anesthesia monitoring, there are no fully mature point-of-care bio-sensing systems. Indeed, it is still evaluated by mathematical models and with indirect parameters like Bispectral Index, which can not provide the actual concentration in blood.The aim of this paper is to investigate solutions for developing a portable system able to monitor simultaneously several different drugs. For this purpose, Cyclic Voltammetries with an anesthetic product and therapeutic compounds were performed for the validation of the system. A multichannel potentiostat has been realized with Off-The-Shelf Components (COTS). Then, results from electrochemical acquisitions on GC SPEs show that the proposed circuitry is suitable for this aim and they prove its high flexibility to develop portable systems for continuous monitoring of anesthetics and therapeutic compounds.

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A potentiostat circuit for multiple implantable electrochemical sensors

Cited by 7 publications

References 11 publications

Anti-inflammatory polymer electrodes for glial scar treatment: bringing the conceptual idea to future results

Anti-inflammatory polymer electrodes for glial scar treatment: bringing the conceptual idea to future results

A potentiostat readout array for nanopore-based DNA sequencing

Simultaneous monitoring of anesthetics and therapeutic compounds with a portable multichannel potentiostat

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