A potential thrombus diagnosis reagent based on P-selectin monoclonal antibody SZ-51 light chain

Xu, Yuanping; Li, Jie; Fang, Wei; Yu, Man; Ru, Binggen

doi:10.1016/j.thromres.2008.06.002

Cited by 5 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…P-selectin has been well characterized and demonstrated as a potential target for thrombus diagnosis and therapy [205, 206]. P-selectin is usually involved in inflammatory disorders (e.g.…”

Section: Pet or Spect Imaging Of Vascular Targets In Cardiovasculamentioning

confidence: 99%

“…Furthermore, high expression level of P-selectin is relevant to the pathological transformation of arterial thrombus and EC activation after a transient ischemia, making it an attractive target in various cardiovascular diseases. Recently, much effort has been devoted to the development of imaging agents that target P-selectin [206, 208, 209]. …”

Section: Pet or Spect Imaging Of Vascular Targets In Cardiovasculamentioning

confidence: 99%

“…In one study, the light chain (LC) of SZ-51 (a mouse mAb against human P-selectin [210]) was expressed in P. pastoris [206]. SZ-LC was shown to bind activated platelet specifically.…”

Section: Pet or Spect Imaging Of Vascular Targets In Cardiovasculamentioning

confidence: 99%

“…SZ-LC was shown to bind activated platelet specifically. Using 99m Tc-MAG3-SZ-LC, the fresh thrombus induced in dog was clearly visualized via SPECT (Figure 2d), indicating that radiolabeled SZ-LC could become a promising new tracer for specific imaging of thrombus [206]. The difference of in vitro and in vivo binding affinity between intact SZ-51 antibody and SZ-LC, however, were not provided in the report.…”

Section: Pet or Spect Imaging Of Vascular Targets In Cardiovasculamentioning

confidence: 99%

“…Arrows indicate the location of copper wire (left, detected by X-ray) and thrombus (right, detected by SPECT). Adapted with permission from [206]. …”

Section: Figurementioning

confidence: 99%

See 4 more Smart Citations

New radiotracers for imaging of vascular targets in angiogenesis-related diseases

Hong

Chen

Zhang

et al. 2014

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

Tremendous advances over the last several decades in positron emission tomography (PET) and single photon emission computed tomography (SPECT) allow for targeted imaging of molecular and cellular events in the living systems. Angiogenesis, a multistep process regulated by the network of different angiogenic factors, has attracted world-wide interests, due to its pivotal role in the formation and progression of different diseases including cancer, cardiovascular diseases (CVD), and inflammation. In this review article, we will summarize the recent progress in PET or SPECT imaging of a wide variety of vascular targets in three major angiogenesis-related diseases: cancer, cardiovascular diseases, and inflammation. Faster drug development and patient stratification for a specific therapy will become possible with the facilitation of PET or SPECT imaging and it will be critical for the maximum benefit of patients.

show abstract

“…P-selectin has been well characterized and demonstrated as a potential target for thrombus diagnosis and therapy [205, 206]. P-selectin is usually involved in inflammatory disorders (e.g.…”

Section: Pet or Spect Imaging Of Vascular Targets In Cardiovasculamentioning

confidence: 99%

Section: Pet or Spect Imaging Of Vascular Targets In Cardiovasculamentioning

confidence: 99%

“…In one study, the light chain (LC) of SZ-51 (a mouse mAb against human P-selectin [210]) was expressed in P. pastoris [206]. SZ-LC was shown to bind activated platelet specifically.…”

Section: Pet or Spect Imaging Of Vascular Targets In Cardiovasculamentioning

confidence: 99%

Section: Pet or Spect Imaging Of Vascular Targets In Cardiovasculamentioning

confidence: 99%

“…Arrows indicate the location of copper wire (left, detected by X-ray) and thrombus (right, detected by SPECT). Adapted with permission from [206]. …”

Section: Figurementioning

confidence: 99%

See 3 more Smart Citations

New radiotracers for imaging of vascular targets in angiogenesis-related diseases

Hong

Chen

Zhang

et al. 2014

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

show abstract

Antibody‐Based Tracers for PET/SPECT Imaging of Chronic Inflammatory Diseases

Lee

Cai

2018

ChemBioChem

View full text Add to dashboard Cite

Chronic inflammatory diseases are often progressive, resulting not only in physical damage to patients but also social and economic burdens, making early diagnosis of them critical. Nuclear medicine techniques can enhance the detection of inflammation by providing functional as well as anatomical information when combined with other modalities such as magnetic resonance imaging, computed tomography or ultrasonography. Although small molecules and peptides were mainly used for the treatment and imaging of chronic inflammatory diseases in the past, antibodies and their fragments have also been emerging for chronic inflammatory diseases as they show high specificity to their targets and can have various biological half‐lives depending on how they are engineered. In addition, imaging with antibodies or their fragments can visualize the in vivo biodistribution of the probes or help monitor therapeutic responses, thereby providing physicians with a greater understanding of drug behavior in vivo and another means of monitoring their patients. In this review, we introduce various targets and radiolabeled antibody‐based probes for the molecular imaging of chronic inflammatory diseases in preclinical and clinical studies. Targets can be classified into three different categories: 1) cell‐adhesion molecules, 2) surface markers on immune cells, and 3) cytokines or enzymes. The limitations and future directions of using radiolabeled antibodies for imaging inflammatory diseases are also discussed.

show abstract

Molecular Imaging in Infection and Inflammation

Shaikh

2022

Advances in Imaging

View full text Add to dashboard Cite

A potential thrombus diagnosis reagent based on P-selectin monoclonal antibody SZ-51 light chain

Cited by 5 publications

References 19 publications

New radiotracers for imaging of vascular targets in angiogenesis-related diseases

New radiotracers for imaging of vascular targets in angiogenesis-related diseases

Antibody‐Based Tracers for PET/SPECT Imaging of Chronic Inflammatory Diseases

Molecular Imaging in Infection and Inflammation

Contact Info

Product

Resources

About