A potential role of mesenchymal stem cells derived from human umbilical cord blood in ameliorating psoriasis-like skin lesion in the rats

Attia, Sally S.; Rafla, M; El-Nefiawy, Nagwa; Hamid, Hemmat; Amin, Mariam Asaad; Fetouh, Marwa A.

doi:10.5603/fm.a2021.0076

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…Electron microscopy showed that the epidermis of psoriasis cured by hUC-MSCs had uniform thickness, complete epidermis layers, clear boundary between the dermis and the epidermis, complete basement membrane, and no gap between tightly connected basal layer cells and basement membrane. Moreover, hUC-MSCs treatment could also reduce the expression of CD4, CD8 and CD31 in T cells ( 18 ). hUC-MSCs can significantly reduce the severity and development of psoriasis, inhibit the infiltration of immune cells into the skin, and downregulate the expression of various proinflammatory cytokines and chemokines, including first inhibiting neutrophil function and then downregulating the production of type I interferon in plasmacytoid dendritic cells ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice

Wang

et al. 2022

Front. Immunol.

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ObjectiveTo investigate the efficacy of indirubin combined with human umbilical cord mesenchymal stem cells (hUC-MSCs) in the treatment of psoriatic lesions in BALB/c mice and to explore the related mechanism of indirubin in the treatment of psoriasis.MethodsA BALB/c mouse psoriasis model induced by imiquimod was established and randomly divided into the control group, model group, indirubin group, hUC-MSCs group, and indirubin combined with hUC-MSCs group. Psoriasis area and severity index (PASI) score was used to observe skin lesion changes in the psoriasis-like mouse model. The epidermal scale, the degree of keratinization, and the infiltration of inflammatory cells were observed by hematoxylin eosin (HE) staining. The concentrations of TNF-α, IFN-γ, IL-17A, and IL-23 in serum of mice were measured using enzyme-linked immunosorbent assay (ELISA).ResultsThe PASI integral trend chart indicates that hUC-MSCs and indirubin and the combination of drugs could relieve the appearance of skin lesions and accelerate the recovery of skin lesions. The indirubin group had the best effect in improving the scale of skin lesions. HE staining showed that the number of parakeratosis cells in the three treatment groups was significantly reduced, the degree of erythrocyte extravasation dermis hyperplasia and inflammatory cell infiltration was significantly lower than that in the model group, and the skin thickness and spleen index of the combined treatment group exhibited the most noticeable improvement. ELISA showed that the concentrations of TNF-α, IFN-γ, IL-17A, and IL-23 in serum of mice in the hUC-MSCs treatment group, indirubin group, and combined administration group were all decreased compared with those in the model group, and the concentrations of IFN-γ, IL-17A, and IL-23 could be decreased significantly in the indirubin group.ConclusionsBoth hUC-MSCs and indirubin can effectively reduce psoriasis-like lesions in BALB/c mice, and the combined administration of these drugs has the best effect.

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Section: Discussionmentioning

confidence: 99%

Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice

Wang

et al. 2022

Front. Immunol.

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“…With advancing technology for administering MSCs, the application of MSCs has emerged as a promising strategy for the treatment of skin inflammatory disease due to their capability of regeneration, immunomodulation, and differentiation ( 45 ). Recent research found that MSCs have efficacy in the reduction of disease severity and epidermal thickness, arranging layers of epidermal layers, and keeping an intact basement membrane through its powerful capability of immunoregulation ( 46 , 47 ). MSCs can be harvested from different tissues as mentioned before, whereas from different resources MSCs may have various therapeutic effects on skin inflammatory diseases.…”

Section: The Effects Of Mscs From Different Resources On Ad and Psori...mentioning

confidence: 99%

Therapeutic effects of mesenchymal stem cells and their derivatives in common skin inflammatory diseases: Atopic dermatitis and psoriasis

Yang

Xiao

et al. 2023

Front. Immunol.

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Chronic skin inflammatory diseases including atopic dermatitis (AD) and psoriasis have been considered uncontrolled inflammatory responses, which have usually troubled patients around the world. Moreover, the recent method to treat AD and psoriasis has been based on the inhibition, not regulation, of the abnormal inflammatory response, which can induce a number of side effects and drug resistance in long-term treatment. Mesenchymal stem/stromal cells (MSCs) and their derivatives have been widely used in immune diseases based on their regeneration, differentiation, and immunomodulation with few adverse effects, which makes MSCs a promising treatment for chronic skin inflammatory diseases. As a result, in this review, we aim to systematically discuss the therapeutic effects of various resources of MSCs, the application of preconditioning MSCs and engineering extracellular vesicles (EVs) in AD and psoriasis, and the clinical evaluation of the administration of MSCs and their derivatives, which can provide a comprehensive vision for the application of MSCs and their derivatives in future research and clinical treatment.

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“…Adipose CD13, CD90, CD105, STRO-1 [5] Osteoarthritis, Multiple Sclerosis [6] Bone marrow CD90, CD105, CD146, CD271 [7] Stroke, Parkinson's disease, Alzheimer's disease [8] Synovial membrane CD44, CD73, CD90, CD105 [9] Rheumatoid arthritis, cartilage repair [10] Perivascular CD90, CD105, CD248, CD271 [11] Rheumatoid arthritis, bone regeneration [11,12] Umbilical cord blood CD44, CD73, CD90, CD105 [13] Ameliorating psoriasis-like skin lesion [14] Umbilical cord tissue CD44, CD73, CD90, CD105 [15] Corneal epithelial repair [15] Placenta CD29, CD73, CD90, CD105 [16] Attenuating spinal cord injury in mice [16] Menstrual blood CD29, CD73, CD90, CD105 [17] Treating critically ill COVID-19 patients [17] Dental pulp CD73, CD90, CD105 [18] Autism spectrum disorder,metatropic dysplasia [19] Fig. 1 The microenvironment of MSCs.…”

Section: Surface Markers Application Prospectmentioning

confidence: 99%

Mesenchymal stem cells and their microenvironment

et al. 2022

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Mesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis and tissue repair. The microenvironment of cells often refers to the intercellular matrix, other cells, cytokines and humoral components. It is also the place for cells’ interaction. The stability of the microenvironment is pivotal for maintaining cell proliferation, differentiation, metabolism and functional activities. Abnormal changes in microenvironment components can interfere cell functions. In some diseases, MSCs can interact with the microenvironment and accelerate disease progression. This review will discuss the characteristics of MSCs and their microenvironment, as well as the interaction between MSCs and microenvironment in disease.

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A potential role of mesenchymal stem cells derived from human umbilical cord blood in ameliorating psoriasis-like skin lesion in the rats

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Folia Morphologica" are listed in PubMed.

Cited by 6 publications

References 33 publications

Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice

Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice

Therapeutic effects of mesenchymal stem cells and their derivatives in common skin inflammatory diseases: Atopic dermatitis and psoriasis

Mesenchymal stem cells and their microenvironment

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