A Potential Role of Collagens Expression in Distinguishing Between Premalignant and Malignant Lesions in Stomach

Zhao, Yuan; Zhou, Tian; Li, Aiqing; Yao, Haomi; He, Fei; Wang, Liang-jing; Si, Jianmin

doi:10.1002/ar.20874

Cited by 49 publications

(47 citation statements)

References 28 publications

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“…Epidermal activation of bcatenin led to the upregulation of a small subset of matrix genes including Col11a1, a prognostic marker of malignant stomach lesions (Zhao et al, 2009) and of colorectal cancers (Suceveanu et al, 2009). We speculate that the stroma of human sebaceous gland tumours bearing LEF1 mutations that inhibit Wnt signalling (Takeda et al, 2006) will have different characteristics to the stroma of pilomatricomas with activating b-catenin mutations (Chan et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin

2011

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SUMMARYHair follicle formation depends on reciprocal epidermal-dermal interactions and occurs during skin development, but not in adult life. This suggests that the properties of dermal fibroblasts change during postnatal development. To examine this, we used a PdgfraEGFP mouse line to isolate GFP-positive fibroblasts from neonatal skin, adult telogen and anagen skin and adult skin in which ectopic hair follicles had been induced by transgenic epidermal activation of b-catenin (EF skin). We also isolated epidermal cells from each mouse. The gene expression profile of EF epidermis was most similar to that of anagen epidermis, consistent with activation of b-catenin signalling. By contrast, adult dermis with ectopic hair follicles more closely resembled neonatal dermis than adult telogen or anagen dermis. In particular, genes associated with mitosis were upregulated and extracellular matrixassociated genes were downregulated in neonatal and EF fibroblasts. We confirmed that sustained epidermal b-catenin activation stimulated fibroblasts to proliferate to reach the high cell density of neonatal skin. In addition, the extracellular matrix was comprehensively remodelled, with mature collagen being replaced by collagen subtypes normally present only in developing skin. The changes in proliferation and extracellular matrix composition originated from a specific subpopulation of fibroblasts located beneath the sebaceous gland. Our results show that adult dermis is an unexpectedly plastic tissue that can be reprogrammed to acquire the molecular, cellular and structural characteristics of neonatal dermis in response to cues from the overlying epidermis.

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Section: Discussionmentioning

confidence: 99%

Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin

2011

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“…In transitional cell carcinoma of the bladder, colXIα1 is one of seven genes with differential expression between superficial and muscle-invasive tumors 45 . ColXIα1 expression is also capable of differentiating premalignant from malignant stomach cancers 46 . See Table 1 for a summary of colXIα1 dysregulation across cancer types.…”

Section: Dysregulation Of Collagen Xiα1 In Cancermentioning

confidence: 99%

Tumor matrix protein collagen XIα1 in cancer

Raglow

Thomas

2015

Cancer Letters

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The extracellular matrix is increasingly recognized as an essential player in cancer development and progression. Collagens are one of the most important components of the extracellular matrix, and have themselves been implicated in many aspects of neoplastic transformation. Collagen XI is a minor collagen whose main physiologic function is to regulate the diameter of major collagen fibrils. The α1 chain of collagen XI (colXIα1), has known pathogenic roles in several musculoskeletal disorders. Recent research has highlighted the importance of colXIα1 in many types of cancer, including its roles in metastasis, angiogenesis, and drug resistance, as well as its potential utility in screening tests and as a therapeutic target. High levels of colXIα1 overexpression have been reported in multiple expression profile studies examining differences between cancerous and normal tissue, and between beginning and advanced stage cancer. Its expression has been linked to poor progression-free and overall survival. The consistency of this data across cancer types is particularly striking, including colorectal, ovarian, breast, head and neck, lung, and brain cancers. This review discusses the role of collagen XIα1 in cancer and its potential as a target for cancer therapy.

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“…miR-29a targets collagens COL3A1, COL11A1, CO-L4A5, and COL4A4, and Fibrillin1 (FBN1), which participate in integrin signaling, focal adhesion and migration. In gastric cancer, transcripts for several collagens, including COLA11A1, are also up-regulated in malignant compared to pre-malignant tumors 28 and COLA11A1 is also up-regulated in cancer-associated fibroblasts of colon adenocarcinomas. 29 Insulin-like Growth Factor 1 (IGF1) is a key player in NSCLC tumorigenesis and metastasis, 30 initiating cell signaling, promoting mitosis, proliferation and differentiation, and inhibiting apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Role of MicroRNAs in Progression and Recurrence of Early-Stage Lung Adenocarcinoma

Singh¹,

Bethune²,

Xu³

et al. 2015

Pulm Res Respir Med Open J

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A Potential Role of Collagens Expression in Distinguishing Between Premalignant and Malignant Lesions in Stomach

Cited by 49 publications

References 28 publications

Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin

Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin

Tumor matrix protein collagen XIα1 in cancer

Role of MicroRNAs in Progression and Recurrence of Early-Stage Lung Adenocarcinoma

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