A potential role for the silent information regulator 2 homologue 1 (<scp>SIRT</scp>1) in periapical periodontitis

Kudo, Hiroshi; Takeichi, Osamu; Hatori, Kuniyuki; Makino, Kosuke; Himi, Kazuma; Ogiso, Bunnai

doi:10.1111/iej.12894

Cited by 11 publications

(6 citation statements)

References 34 publications

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“…Several studies have explored the associations between SIRT1 and VEGF in angiogenesis. An in vitro study of Kudo et al (2018) showed that mRNA expression of SIRT1 in Human umbilical vein endothelial cells (HUVECs) peaked after 6 h of incubation with a SIRT1 activator, resveratrol. However, VEGF mRNA showed delayed expression, 4 h later than SIRT1, suggesting that SIRT1-mediated stimulation of expression.…”

Section: Discussionmentioning

confidence: 99%

Buyang Huanwu Decoction Targets SIRT1/VEGF Pathway to Promote Angiogenesis After Cerebral Ischemia/Reperfusion Injury

Zheng

Shan

et al. 2018

Front. Neurosci.

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Background: Ischemia stroke is known as the major cause of morbidity and mortality. Buyang Huanwu Decoction (BHD), a classical traditional Chinese medicine (TCM) formula, has been used to prevent and treat stoke for hundreds of years. The purpose of present study is to investigate the effects of BHD on angiogenesis in rats after cerebral ischemia/reperfusion (I/R) injury targeting Silent information regulator 1 (SIRT1) / Vascular endothelial growth factor (VEGF) pathway.Methods: The cerebral I/R injury model was induced by middle cerebral artery occlusion (MCAO). Adult Sprag-Dawley (SD) rats were randomly divided into five groups: sham group, normal saline (NS) group, BHD group, BHD+EX527 (SIRT1 specific inhibitor) group, and NS+EX527 group. Each group was divided into the subgroups according to 1, 3, 7, or 14 days time-point after cerebral ischemia/reperfusion, respectively. Neurological function score (NFS) was evaluated by the Rogers scale; microvascular density (MVD) in brain tissue around infarction area was observed by immunofluorescence; and the expression of SIRT1 and VEGF was assessed by Western Blot and Quantitative Real-time-PCR.Results: BHD can significantly improve NFS (P < 0.05), increase the MVD in the boundary ischemic area (P < 0.01) and elevate the expression of protein and mRNA of SIRT1 and VEGF following I/R injury (P < 0.01). In contrast, treatment with EX527 reversed the BHD-induced improvements in NFS (P < 0.01) and decreased the MVD (P < 0.01) and the expression of SIRT1 and VEGF (P < 0.05).Conclusion: BHD exerts neuroprotection targeting angiogenesis through the up-regulation of SIRT1/VEGF pathway against cerebral ischemic injury in rats.

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Section: Discussionmentioning

confidence: 99%

Buyang Huanwu Decoction Targets SIRT1/VEGF Pathway to Promote Angiogenesis After Cerebral Ischemia/Reperfusion Injury

Zheng

Shan

et al. 2018

Front. Neurosci.

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“…Recent studies have shown that sirtuins are involved in the pathogenesis of apical periodontitis (Table 1). Kudo et al evaluated the importance of SIRT1 in apical granulomas and they found that SIRT1 expression was rather high in gingival lesions compared with healthy gingival tissues (Kudo et al, 2018a;Kudo et al, 2018b). Furthermore, SIRT1 was shown to be colocalized with Ki-67, vascular endothelial growth factor (VEGF), VEcadherin, and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in…”

Section: Apical Periodontitismentioning

confidence: 99%

Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases

et al. 2022

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Sirtuins are a family of nicotinamide adenine dinucleotide (NAD)+-dependent histone deacetylases, comprising seven members SIRT1-SIRT7. Sirtuins have been extensively studied in regulating ageing and age-related diseases. Sirtuins are also pivotal modulators in oxidative stress and inflammation, as they can regulate the expression and activation of downstream transcriptional factors (such as Forkhead box protein O3 (FOXO3a), nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB)) as well as antioxidant enzymes, through epigenetic modification and post-translational modification. Most importantly, studies have shown that aberrant sirtuins are involved in the pathogenesis of infectious and inflammatory oral diseases, and oral cancer. In this review, we provide a comprehensive overview of the regulatory patterns of sirtuins at multiple levels, and the essential roles of sirtuins in regulating inflammation, oxidative stress, and bone metabolism. We summarize the involvement of sirtuins in several oral diseases such as periodontitis, apical periodontitis, pulpitis, oral candidiasis, oral herpesvirus infections, dental fluorosis, and oral cancer. At last, we discuss the potential utilization of sirtuins as therapeutic targets in oral diseases.

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“…Endodontic research community has been mostly concerned with microbiology, histopathology, diagnosis and treatment of AP (de Miranda & Colombo, ; Kruse, Spin‐Neto, Reibel, Wenzel, & Kirkevang, ; Kudo et al, ; Li, Tong, & Ling, ; Ricucci, Loghin, Gonçalves, Rôças, & Siqueira, ). Yet, understanding the aetiology of disease requires other information than that related to biological mechanism in the individual.…”

Section: Introductionmentioning

confidence: 99%

Socio‐economic and health status as a predictor of apical periodontitis in adult patients in Croatia

et al. 2018

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Objective A few studies focused on determinants of apical periodontitis other than technical or biological factors. This research aimed to investigate to what extent socio‐economic and health status can predict apical periodontitis in adult patients. Subjects and Methods The cross‐sectional study included 599 adult patients. Medical history, health habits and socio‐economic status of each participant were recorded using a self‐administered structured questionnaire. For caries detection, the World Health Organization diagnostic thresholds were used, and oral hygiene level was estimated using plaque index. Periapical index system was used to analyse the periapical status of all teeth. Dental, socio‐economic and health‐related variables were tested against dependent variable (periapical disease ratio) in a multiple linear regression analysis. Results Dental independent variables explained 71.7% of the observed variation in periapical disease ratio (R2 = 0.717; p < 0.001). Periapical disease ratio increased with the increase in number of carious teeth, plaque index and number of root‐filled teeth, but also with decrease in number of coronal fillings (all p < 0.001). Socio‐economic and health‐related variables accounted for lower portion of variability, 15.5% and 12.9%, respectively (both p < 0.001). Conclusions Dental variables are more important predictors of periapical status than socio‐economic and health‐related variables.

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A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis

Abstract: These findings suggest that SIRT1 may stimulate angiogenesis in periapical granulomas by triggering the proliferation of endothelial cells and inducing VEGF and VE-cadherin expression.

Cited by 11 publications

References 34 publications

Buyang Huanwu Decoction Targets SIRT1/VEGF Pathway to Promote Angiogenesis After Cerebral Ischemia/Reperfusion Injury

Buyang Huanwu Decoction Targets SIRT1/VEGF Pathway to Promote Angiogenesis After Cerebral Ischemia/Reperfusion Injury

Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases

Socio‐economic and health status as a predictor of apical periodontitis in adult patients in Croatia

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