A Potential Role for the Phospholipase D2-Aquaporin-3 Signaling Module in Early Keratinocyte Differentiation: Production of a Phosphatidylglycerol Signaling Lipid

Bollag, Wendy B.; Xie, Dongdong; Zheng, Xiangjian; Zhong, Xiaofeng

doi:10.1038/sj.jid.5700921

Cited by 67 publications

(107 citation statements)

References 37 publications

(42 reference statements)

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“…However, the polyunsaturated isoforms of PG appear to promote differentiation at the expense of proliferation [75,76]. This evidence supports the conclusion that DNA synthesis is inhibited by the PG produced by PLD2 [76].…”

Section: Mammalian Cellssupporting

confidence: 77%

“…PG from Hen's eggs [76] (44 % 18:0/16:0) accelerates proliferation, but this is inhibited by PG from Glycine max [75] (72 % 18:2/18:3). However, the polyunsaturated isoforms of PG appear to promote differentiation at the expense of proliferation [75,76]. This evidence supports the conclusion that DNA synthesis is inhibited by the PG produced by PLD2 [76].…”

Section: Mammalian Cellsmentioning

confidence: 99%

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Is phosphatidylglycerol essential for terrestrial life?

Furse

2016

J Chem Biol

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Lipids are of increasing importance in understanding biological systems. Lipids carrying an anionic charge are noted in particular for their electrostatic interactions with both proteins and divalent cations. However, the biological, analytical, chemical and biophysical data of such species are rarely considered together, limiting our ability to assess the true role of such lipids in vivo. In this review, evidence from a range of studies about the lipid phosphatidylglycerol is considered. This evidence supports the conclusions that this lipid is ubiquitous in living systems and generally of low abundance but probably fundamental for terrestrial life. Possible reasons for this are discussed and further questions posed.

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Section: Mammalian Cellssupporting

confidence: 77%

Section: Mammalian Cellsmentioning

confidence: 99%

Is phosphatidylglycerol essential for terrestrial life?

Furse

2016

J Chem Biol

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“…It is clear that AQP3 plays a role in keratinocyte proliferation in both human and mouse epidermis (Hara-Chikuma and Verkman, 2008b;Nakahigashi et al, 2011) and AQP3-facilitated water transport is important for keratinocyte migration in the mouse (Hara-Chikuma and Verkman, 2008a). Furthermore, despite some debate over a role for AQP3 in keratinocyte differentiation in mice (Bollag et al, 2007;Hara-Chikuma et al, 2009;Kim and Lee, 2010), evidence in human keratinocytes supports a role for AQP3 in the negative regulation of differentiation (and promotion of proliferation) through the downregulation of Notch1, a known mediator of keratinocyte differentiation (Guo et al, 2013).…”

Section: Aqp3mentioning

confidence: 99%

Defective channels lead to an impaired skin barrier

Blaydon¹,

Kelsell²

2014

Journal of Cell Science

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Channels are integral membrane proteins that form a pore, allowing the passive movement of ions or molecules across a membrane (along a gradient), either between compartments within a cell, between intracellular and extracellular environments or between adjacent cells. The ability of cells to communicate with one another and with their environment is a crucial part of the normal physiology of a tissue that allows it to carry out its function. Cell communication is particularly important during keratinocyte differentiation and formation of the skin barrier. Keratinocytes in the skin epidermis undergo a programme of apoptosis-driven terminal differentiation, whereby proliferating keratinocytes in the basal (deepest) layer of the epidermis stop proliferating, exit the basal layer and move up through the spinous and granular layers of the epidermis to form the stratum corneum, the external barrier. Genes encoding different families of channel proteins have been found to harbour mutations linked to a variety of rare inherited monogenic skin diseases. In this Commentary, we discuss how human genetic findings in aquaporin (AQP) and transient receptor potential (TRP) channels reveal different mechanisms by which these channel proteins function to ensure the proper formation and maintenance of the skin barrier.

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“…13,14 ). In a recent study, we have shown that manipulations that alter the function of this PLD2/AQP3/PG signaling module can inhibit epidermal keratinocyte proliferation and promote differentiation ( 17 ).…”

Section: Methodsmentioning

confidence: 99%

Cell wounding activates phospholipase D in primary mouse keratinocytes

Arun

Xie

Howard

et al. 2013

Journal of Lipid Research

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Journal of Lipid Research Volume 54, 2013 581characterized by growth arrest and expression of the mature keratins 1 and 10 in the fi rst differentiated layer of the epidermis, the spinous layer. Early differentiation in the spinous layer is followed by further differentiation in the granular layer, which is accompanied by expression of proteins that are essential for the formation of the cornifi ed envelope and corneocytes. The corneocytes constitute the outer layer of the epidermis, the stratum corneum, and give skin its resilience to mechanical stress (as reviewed in Ref. 1 ). Defi ciencies in the mechanical barrier function of the epidermis result in skin diseases. For example, epidermolysis bullosa simplex and epidermolytic hyperkeratosis arise through mutations in keratins comprising the intermediate fi laments and are characterized by extensive blistering and epidermal sloughing as a result of the mechanical stresses encountered by routine interactions with the environment (as reviewed in Ref.2 ). Many tissues of the body in addition to the skin are exposed to mechanical stresses that result in tearing, or disrupting, the plasma membrane of the constituent cells. These disruptions will result in cell death if left unrepaired. However, cells possess an active plasma membrane repair process that can restore plasma membrane integrity if the disruption is not too extensive (as reviewed in Ref.3 ). For example, intestinal cells in the gastrointestinal tract are subjected to mechanical perturbations during the transit of a food bolus; these plasma membrane disruptions can be repaired to allow cell survival ( 4-6 ). Similarly, eccentric contraction of skeletal muscle as a result of downhill treadmill running induces plasma membrane disruptions that are largely repaired ( 7 ). Routine ambulation also appears to lead to plasma membrane disruptions in the epidermis of the digits ( 8 ). Therefore, it is critical that cells in these mechanically active tissues be able to repair membrane Keratinocytes form the epithelium of the skin, the epidermis, and comprise several cell layers. As keratinocytes migrate up from the stratum basale, they undergo a distinct pattern of differentiation that is essential for the function of the skin as a protective barrier. This pattern is Abbreviations: 1,25(OH) 2 D 3 , 1,25-dihydroxyvitamin D 3 ; AQP3, aquaporin 3; FIPI, 5-fl uoro-2-indolyl des-chlorohalopemide; HBSS, Hank's buffered salt solution; K-SFM, keratinocyte serum-free medium; PEt, phosphatidylethanol; PG, phosphatidylglycerol; PIP 2 , phosphatidylinositol 4,5-bisphosphate; PLD, phospholipase D; SFKM, serum-free keratinocyte medium; TPA, 12-O -tetradecanoylphorbol 13-acetate.

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A Potential Role for the Phospholipase D2-Aquaporin-3 Signaling Module in Early Keratinocyte Differentiation: Production of a Phosphatidylglycerol Signaling Lipid

Cited by 67 publications

References 37 publications

Is phosphatidylglycerol essential for terrestrial life?

Is phosphatidylglycerol essential for terrestrial life?

Defective channels lead to an impaired skin barrier

Cell wounding activates phospholipase D in primary mouse keratinocytes

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