A potential role for regulatory T-cells in the amelioration of DSS induced colitis by dietary non-digestible polysaccharides

Hartog, Anita; Belle, Fabiën N.; Bastiaans, Jacqueline; Graaff, Priscilla de; Garssen, Johan; Harthoorn, Lucien F.; Vos, Anneke S. de

doi:10.1016/j.jnutbio.2014.10.011

Cited by 58 publications

(37 citation statements)

References 44 publications

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“…Treg could be a potential target for dietary modulation of colitis, as green tea polyphenol epigallocatechin gallate induced forkhead box P3 (FoxP3) expression and increased the percentage of Treg in spleen and lymph nodes in vivo . Moreover, dietary fiber reduced signs of dextran sulfate sodium (DSS)‐induced colitis in mice and increased Treg/Th17 ratios in lymphocytes in mesenteric lymph node (MLN) …”

Section: Introductionmentioning

confidence: 99%

Dietary Prevention of Colitis by Aronia Berry is Mediated Through Increased Th17 and Treg

Pei

Martin

Valdez

et al. 2018

Molecular Nutrition Food Res

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Scope Increased fruit consumption is associated with reduced risk of colitis. It has been investigated whether the anti‐colitic effects of the polyphenol‐rich aronia berry (Aronia mitschurinii ‘Viking’) are mediated through Th17 and Treg. Methods and results Colitis is induced in recombinase activating gene‐1 deficient mice injected with syngeneic CD4+CD62L+ naïve T cells. Mice consume either 4.5% w/w aronia‐berry‐supplemented or a control diet concurrent with T cell transfer. The extent of colitis and immunocyte populations are evaluated at weeks 3 to 7 after transfer. Aronia consumption prevents colitic wasting and reduces colon weight/length ratios relative to the control diet at weeks 5 and 7. Compared to the control diet, aronia feeding increases Treg in mesenteric lymph node at all colitis stages. Treg and regulatory Th17 subpopulations (IL‐17A+IL‐10+ and IL‐17A+IL‐22+) are increased in lamina propria and spleen at week 5 in aronia‐fed mice. Aronia feeding also decreases total CD4+ cells but increases colonic Tregs. The ability of aronia to modulate colonic cytokines is associated with functional T cell IL‐10 and increased diversity of microbiota. Conclusions Aronia berry consumption inhibits adoptive transfer colitis by increasing Treg and regulatory Th17 cells. Dietary modulation of T cells is dynamic and precedes colitic wasting.

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Section: Introductionmentioning

confidence: 99%

Dietary Prevention of Colitis by Aronia Berry is Mediated Through Increased Th17 and Treg

Pei

Martin

Valdez

et al. 2018

Molecular Nutrition Food Res

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“…Another study found that oral intake of a specific multi-fibre mix (MFibre), designed to match the fibre content of a healthy diet, counteracted IBD-like intestinal inflammation and weight loss in dextran sodium sulphate (DSS)-treated mice [62]. The authors suggested that the reduction in inflammation might be brought about, at least in part, by the MFibre-induced decrease in inflammatory cytokines, including TNF-α, increase in IL-10, and relative increase in T-regulatory cells in the mesenteric lymph nodes.…”

Section: Resultsmentioning

confidence: 99%

Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

2017

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We wanted to investigate the current knowledge on the impact of diet on anti-TNF response in inflammatory bowel diseases (IBD), to identify dietary factors that warrant further investigations in relation to anti-TNF treatment response, and, finally, to discuss potential strategies for such investigations. PubMed was searched using specified search terms. One small prospective study on diet and anti-TNF treatment in 56 patients with CD found similar remission rates after 56 weeks among 32 patients with good compliance that received concomitant enteral nutrition and 24 with poor compliance that had no dietary restrictions (78% versus 67%, p = 0.51). A meta-analysis of 295 patients found higher odds of achieving clinical remission and remaining in clinical remission among patients on combination therapy with specialised enteral nutrition and Infliximab (IFX) compared with IFX monotherapy (OR 2.73; 95% CI: 1.73–4.31, p < 0.01, OR 2.93; 95% CI: 1.66–5.17, p < 0.01, respectively). In conclusion, evidence-based knowledge on impact of diet on anti-TNF treatment response for clinical use is scarce. Here we propose a mechanism by which Western style diet high in meat and low in fibre may promote colonic inflammation and potentially impact treatment response to anti-TNF drugs. Further studies using hypothesis-driven and data-driven strategies in prospective observational, animal and interventional studies are warranted.

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“…The interaction between a disturbed microbial composition, the intestinal mucosal barrier and the mucosal immune system plays an important role in inflammatory bowel diseases and its chronicity. Hartog et al reported that oral intake with the major component of resistant starch counteracts inflammatory bowel diseases-like intestinal inflammation and weight loss in dextran sodium sulphate treated mice [41]. This reduction in inflammation might be brought about by the resistant starch-induced decrease in inflammatory cytokines, increase in IL-10 and the relative increase in Treg cells in the mesenteric lymph nodes.…”

Section: Cell Signaling Pathways Related To Physiological Effect Of Rmentioning

confidence: 99%

Resistant Starch Regulates Gut Microbiota: Structure, Biochemistry and Cell Signalling

Yang

Darko

Huang

et al. 2017

Cell Physiol Biochem

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Starch is one of the most popular nutritional sources for both human and animals. Due to the variation of its nutritional traits and biochemical specificities, starch has been classified into rapidly digestible, slowly digestible and resistant starch. Resistant starch has its own unique chemical structure, and various forms of resistant starch are commercially available. It has been found being a multiple-functional regulator for treating metabolic dysfunction. Different functions of resistant starch such as modulation of the gut microbiota, gut peptides, circulating growth factors, circulating inflammatory mediators have been characterized by animal studies and clinical trials. In this mini-review, recent remarkable progress in resistant starch on gut microbiota, particularly the effect of structure, biochemistry and cell signaling on nutrition has been summarized, with highlights on its regulatory effect on gut microbiota.

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A potential role for regulatory T-cells in the amelioration of DSS induced colitis by dietary non-digestible polysaccharides

Cited by 58 publications

References 44 publications

Dietary Prevention of Colitis by Aronia Berry is Mediated Through Increased Th17 and Treg

Dietary Prevention of Colitis by Aronia Berry is Mediated Through Increased Th17 and Treg

Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

Resistant Starch Regulates Gut Microbiota: Structure, Biochemistry and Cell Signalling

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