A potential role for microbial superantigens in the pathogenesis of systemic autoimmune disease

Friedman, Steven; Posnett, David N.; Tumang, Joseph R.; Crow, Mary K.; Cole, Barry C.

doi:10.1002/art.1780340412

Cited by 131 publications

(67 citation statements)

References 87 publications

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“…TCR recognition of the antigen results in stimulation and clonal proliferation of the activated T cell. In addition, bacteria and viruses also express superantigens which are capable of stimulating T cells having particular Vb gene segments in both CD4 þ and CD8 þ T cell compartments, independent of normal MHC TCR recognition [16].…”

Section: Introductionmentioning

confidence: 99%

Oligoclonal T cell expansions in patients with Behçet's disease

Direşkeneli

Ekşioğlu-Demiralp²,

Kibaroglu³

et al. 1999

Clinical and Experimental Immunology

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SUMMARYBehçet's disease (BD) is a multisystem disorder with oral and genital ulcers, mucocutaneous, ocular, joint, vascular and central nervous system involvement. In this study, the peripheral T cell repertoire was analysed in patients with BD with MoAbs against T cell receptor (TCR) Vb gene products in CD4 þ and CD8 þ T cell compartments, and these were compared with rheumatoid arthritis (RA) patients and healthy controls (HC). In the CD4 þ T cell compartment, oligoclonal TCR Vb expression was observed in 56% of BD (10/18), 71% of RA (5/7) patients and 21% (3/14) of HC. In the CD8 þ T cell group 50% of BD (9/18), 57% of RA patients and 28% of HC (4/14) had an oligoclonal TCR repertoire. An increase of TCR Vb5.1 subset was observed in five BD patients among CD8 þ T cells. Other elevations of TCR Vb subsets were heterogeneously distributed with one to three different Vb subsets. Our results suggest an antigen-driven oligoclonal increase of T cells in BD. There was no overall increase in any Vb group to suggest a superantigen effect. Analysis of the responsible antigens causing the increase in T cell subsets may give insights into the aetiopathogenesis of BD and immunomodulation of these T cells may lead to new treatments.

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Section: Introductionmentioning

confidence: 99%

Oligoclonal T cell expansions in patients with Behçet's disease

Direşkeneli

Ekşioğlu-Demiralp²,

Kibaroglu³

et al. 1999

Clinical and Experimental Immunology

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“…One species of mycoplasma, Mycoplasma arthritidis, produces a superantigen that binds both to class I1 major histocompatibility complex antigens on B cells and to T cell receptors with specific V , gene products. This binding to B and T cells causes nonspecific activation of B cells without the need for T cell antigen binding (12,14). This superantigen may also activate T cells (15).…”

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confidence: 99%

“…This superantigen may also activate T cells (15). The immune response to superantigens in vivo could permit the development of autoimmunity (12).…”

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confidence: 99%

Ureaplasma urealyticum and mycoplasma hominis in women with systemic lupus erythematosus

Ginsburg

Kundsin

Walter

et al. 1992

Arthritis & Rheumatism

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Objective. To determine the prevalence of genitourinary mycoplasma infection in women with systemic lupus erythematosus (SLE).Methods. Urine specimens from 49 patients with SLE and 22 patients with chronic fatigue syndrome (CFS) were cultured for mycoplasma. Patient records were reviewed for medical history and SLE disease activity.Results. Sixty-three percent of the SLE patients were culture positive, compared with 4.5% of the CFS patients (P < 0.001). Neither corticosteroid treatment, SLE activity, nor age accounted for this difference.Conclusion. Genitourinary mycoplasma colonization occurs significantly more frequently in SLE than in CFS.The mycoplasmas are a group of microorganisms which cause a variety of human diseases involv-

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“…Furthermore, it has been reported that some rheumatoid arthritis (RA) patients exhibit a clonal expansion of T cells in the synovial fluid. These T cells express T cell receptor (TCR) Vp14 (14) and other TCR specificities (14)(15)(16)(17)(18)(19)(20)(21)(22), which suggests that a superantigen(s) might be involved in the development of chronic arthritis. Not all RA patients exhibit a clonal expansion and activation of T cells, however (23,24).…”

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confidence: 99%

“…Indeed, a large variety of V, or VDJ families have been reported to be overrepresented in the synovium of RA patients (14)(15)(16)(17)(18), and therefore a number of superantigens or nominal antigens may be involved in the initiation and perpetuation of RA. The results of the studies presented here suggest that the development of arthritis is facilitated by the presence of a large population of antigen-reactive T cells, as would be found for superantigens.…”

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confidence: 99%

T Cell Influence on Superantigen‐Induced Arthritis in MRL‐lpr/lpr Mice

Mountz

Zhou

Long

et al. 1994

Arthritis & Rheumatism

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Objective. To define the influence of the T cell receptor (TCR) and the lpr autoimmune gene on the induction and progression of superantigen-induced arthritis in V,8 transgenic MRL-lprllpr mice.Methods. The time to onset and the extent of synovial hyperplasia after the induction of arthritis by intraarticular injection of staphylococcal enterotoxin B (SEB) were compared in mice having T cells that bear the V, $ transgene alone (V@ TCR transgenic M R G +/+), the lpr gene without the Vs8 gene (nontransgenic MRL-lpr/lpr), both the Vs8 gene and the lpr gene Results. At day 30, increased synovial cells were observed in all SEB-treated mice, but the increase was greatest in the V@ transgenic MRGlprllpr mice. T cell involvement was indicated by the inability of either heat-denatured SEB or SEA to induce severe arthritis, the reduction in the severity of the arthritis on systemic treatment with CSA or anti-VgS, and the correlation of synovial hyperplasia with in vitro SEB reactivity of T cells.Conclusion. Theseobservations suggest that superantigens can induce chronic arthritis and that the induction and progression of the arthritis requires an underlying T cell defect in anergy induction in addition to exposure to the superantigen.

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A potential role for microbial superantigens in the pathogenesis of systemic autoimmune disease

Cited by 131 publications

References 87 publications

Oligoclonal T cell expansions in patients with Behçet's disease

Oligoclonal T cell expansions in patients with Behçet's disease

Ureaplasma urealyticum and mycoplasma hominis in women with systemic lupus erythematosus

T Cell Influence on Superantigen‐Induced Arthritis in MRL‐lpr/lpr Mice

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