A potential role for adjunctive omega-3 polyunsaturated fatty acids for depression and anxiety symptoms in recent onset psychosis: Results from a 16 week randomized placebo-controlled trial for participants concurrently treated with risperidone

Abstract

contributors Drs. Robinson and Szeszko were Co-Principal Investigators for the study and directed all aspects of the study from inception to manuscript submission. Drs. Gallego, Hanna, Zhang and Birnbaum treated study participants and did assessments. Dr. John devised the study statistical plan and performed the analyses. Ms. Greenberg did research assessments. Ms. Naraine coordinated all aspects of the study. Dr. Peters contributed expertise on omega-3 effects for the study design and execution. Dr. McNamara contributed his expertise on omega-3 effects and supervised the analysis of omega-3 levels. Dr. Malhotra was the Principal Investigator for the Empire Clinical Research Investigator Program award that supported the study. All authors contributed to the development of the manuscript and have approved the submitted version.

The effect of flaxseed on physical and mental fatigue in children and adolescents with overweight/obesity: a randomised controlled trial

“…However, the lack of effect in this study is likely due to healthy mental status of our participants as in previous studies benefits of long-chain ω-3 fatty acids were observed in individuals at-risk of mental states (52) or recent onset psychosis (19) .…”

“…Also, patients with chronic fatigue syndrome had low concentrations of EPA and DHA in their erythrocytes (16) . Clinical trials have also shown the benefit of a mixture of α-linolenic acid and linoleic acid on fatigue of healthy individuals (17) and that of long-chain ω-3 fatty acids on patients with disease-related fatigue, such as patients with rheumatoid arthritis (18) , psychotic disorders (19) , and also in sport-induced fatigue (20) .…”

“…Flaxseed did not affect mood disorders, including depression, anxiety, and stress. Long-chain ω-3 fatty acids have been proposed as a strategy for preventing or treating mood disorders such as depression and anxiety in certain conditions (19,52,53) although no such document is available for α-linolenic acid.…”

“…A number of clinical trials have reported beneficial effects of ω-3 fatty acids on fatigue, (e.g., [17][18][19][20] but none of these trials have measured fatigue as the primary outcome. In addition, they except one (17) examined disease-related fatigue and recruited participants with inflammatory diseases.…”

Dietary Supplementation with Omega-3 Polyunsaturated Fatty Acids Reduces Opioid-Seeking Behaviors and Alters the Gut Microbiome

“…A recurrent observation is that dietary omega-3 supplementation relieves anxiety and depression symptoms in mood disorders often co-diagnosed in substance abuse disorder patients (reviews; [22][23][24]. Accordingly, n-3 supplements enriched in DHA have been shown to reduce anxiogenic affective-like behaviors in preclinical models [22,25,26] and clinical trials [23,[27][28][29][30][31]. DHA is required as a structural component of plasma, microsomal and synaptic membranes in the brain [32,33] and is essential for numerous brain functions including development [34], and diverse cellular functions [35][36][37][38][39].…”