A Potential Polymeric Nanogel System for Effective Delivery of Chlorogenic Acid to Target Collagen-Induced Arthritis

Ma, Yuxia; Song, Yuxiu; Ma, Fang; Chen, Guifang

doi:10.1007/s10904-019-01421-8

Cited by 5 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 26 , 27 At 15 days post-injection, CIA severity of hind paws was scored according to the following articular index (AI): 0, no erythema or swelling; 1, minor erythema or swelling; 2, moderate edema and signs extending to the tarsals; 3, significant edema, restricted joint utilization, and signs extending to the metatarsals; or 4, serious signs and excessive edema with joint rigidity extending to the entire hind paw. 28 , 29 The scores of each paw were summed to calculate the total AI score for each animal.…”

Section: Methodsmentioning

confidence: 99%

Long-Circulating Lipid Nanospheres Loaded with Flurbiprofen Axetil for Targeted Rheumatoid Arthritis Treatment

Chen,

Liu,

Wang

et al. 2023

IJN

View full text Add to dashboard Cite

Background Flurbiprofen axetil (FA) is a non-steroidal anti-inflammatory drug with good analgesic and anti-inflammatory effects. However, it suffers from poor solubility, short circulation time, and off-target binding profile, which significantly limit its clinical application. Here, we loaded FA into stealth lipid microspheres modified with the arginine-glycine-aspartic acid (RGD) peptide (cRGD-FA-SLM), and examined the therapeutic potential of the resulting platform for the treatment of rheumatoid arthritis (RA). Methods cRGD-FA-SLM was prepared by high pressure homogenization, and its toxicity and uptake by macrophages were examined using cultures of RAW264.7 cells. Hemolysis and hepatotoxicity tests were performed to assess the safety of the developed platform, while its pharmacokinetics, biodistribution, and therapeutic efficacy were investigated in a collagen-induced arthritis rat model. Results cRGD-FA-SLM showed homogeneous spherical morphology and efficient encapsulation of FA. The developed platform was non-toxic to normal macrophages and was selectively internalized by lipopolysaccharide-activated macrophages in vitro, while it distributed mainly to arthritic joints and significantly prolonged FA in circulation in vivo. cRGD-FA-SLM also significantly reduced the expression of prostaglandin E2 and alleviated joint edema and bone erosion, showing prolonged analgesic effects in arthritic rats. Conclusion cRGD-FA-SLM shows good inflammation-targeting ability and prolongs drug circulation in vivo, suggesting promise as an anti-inflammatory and analgesic agent for targeted RA treatment.

show abstract

Section: Methodsmentioning

confidence: 99%

Long-Circulating Lipid Nanospheres Loaded with Flurbiprofen Axetil for Targeted Rheumatoid Arthritis Treatment

Chen,

Liu,

Wang

et al. 2023

IJN

View full text Add to dashboard Cite

show abstract

“…Folic acid conjugated nanogel showed controlled and targeted release of chlorogenic acid for 25 days with anti‐inflammatory, analgesic, and protective activity against the clinical signs of RA. This delivery also effectively retards the expression and activation of proinflammatory cytokines, mediators, and NO at a 10 mg/ml dose in CIA rats (Ma, Song, Ma, & Chen, 2020).…”

Section: Drug Delivery System Of Polyphenol For Treatment Of Ramentioning

confidence: 99%

Dietary polyphenols for management of rheumatoid arthritis: Pharmacotherapy and novel delivery systems

Maity

Wairkar

2022

Phytotherapy Research

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a chronic, complex, systemic autoimmune disease causing chronic inflammation, swelling, and pain. It affects pulmonary and ocular physiology, gastrointestinal disturbance, skeletal disorders, and renal malfunctioning. Although conventional and biological drugs available to treat RA are potent and effective, they lead to life‐threatening side effects and patient discomfort. Hence, alternative therapies are explored for their treatment which is safe, effective, and economical. Herbal drugs are widely used as an alternative therapy and some medicinal plants, especially dietary polyphenols proved their efficacy in treating RA. Polyphenols are secondary metabolites of plants possessing several pharmacological actions. They exert anti‐inflammatory, immunomodulatory and anti‐rheumatoid activity by modulating tumor necrosis factor, mitogen‐activated protein kinase, nuclear factor kappa‐light‐chain‐enhancer of activated B cells, and c‐Jun N‐terminal kinases. Thus, polyphenols could be a promising option for the management of RA. Unfortunately, polyphenols suffer from poor bioavailability due to their physicochemical properties and incorporation into novel delivery systems such as liposomes, nanoparticles, nanoemulsions, micelles improved their oral bioavailability. This review article summarizes dietary polyphenols, their pharmacological actions and novel delivery systems for the treatment of RA. Nevertheless, the commercial translation of polyphenols could be only possible after establishing their safety profile and successful clinical trials.

show abstract

Study on Eu3+-doped MgAl-LDH as carrier of chlorogenic acid and their fluorescent property

Shang,

Li,

Guo

et al. 2024

J IRAN CHEM SOC

View full text Add to dashboard Cite

A Potential Polymeric Nanogel System for Effective Delivery of Chlorogenic Acid to Target Collagen-Induced Arthritis

Cited by 5 publications

References 47 publications

Long-Circulating Lipid Nanospheres Loaded with Flurbiprofen Axetil for Targeted Rheumatoid Arthritis Treatment

Long-Circulating Lipid Nanospheres Loaded with Flurbiprofen Axetil for Targeted Rheumatoid Arthritis Treatment

Dietary polyphenols for management of rheumatoid arthritis: Pharmacotherapy and novel delivery systems

Study on Eu3+-doped MgAl-LDH as carrier of chlorogenic acid and their fluorescent property

Contact Info

Product

Resources

About