A potential oral microbiome signature associated with coronary artery disease in Tunisia

Bouzid, Fériel; Gtif, Imen; AlFadhli, Suad; Charfeddine, S.; Ghorbel, Walid; Abdelhédi, Rania; Benmarzoug, Riadh; Abid, Leïla; Abdelmoula, Nouha Bouayed; Elloumi, Inés; Masmoudi, Saber; Rebaï, Ahmed; Kharrat, Najla

doi:10.1042/bsr20220583

Cited by 11 publications

(6 citation statements)

References 45 publications

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“…Veillonella could be found in atherosclerosis plaque and associated with cholesterol levels 43 . In addition, Veillonella is high relative abundance in CAD patients 35,44 . These ndings suggested that the differences in bacterial abundance between the three groups may be linked to the progression of CAD and lipid metabolism in dyslipidemia patients.…”

Section: Discussionmentioning

confidence: 99%

Association of gut microbiota with dyslipidemia and chronic coronary syndrome patients undergoing coronary angiography

Luangphiphat,

Prombutara,

Muangsillapasart

et al. 2023

Preprint

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Chronic coronary syndrome (CCS) has a high mortality rate, and dyslipidemia is a major risk factor. Atherosclerosis, a cause of CCS, is influenced by gut microbiota dysbiosis and its metabolites. We aimed to study the diversity and composition of gut microbiota and related clinical parameters among CCS patients undergoing coronary angiography and dyslipidemia patients in comparison to healthy volunteers in Thailand. We reported that CCS patients had more risk factors and higher inflammatory marker, high-sensitivity C-reactive protein (hs-CRP) than others. We showed that the alpha diversity was lower in dyslipidemia and CCS patients than in the healthy group. A significant difference in the composition of gut microbiota was observed among the three groups. The relative abundance of Proteobacteria, Fusobacteria, Enterobacteriaceae, Prevotella and Streptococcus were significantly increased while Roseburia, Ruminococcus and Faecalibacterium were lower in CCS patients. In CCS patients, Lachnospiraceae, Peptostreptococcaceae and Pediococcus were positively correlated with hs-CRP. In dyslipidemia patients, Megasphaera was strongly positively correlated with triglyceride (TG) level and negatively correlated with high-density lipoprotein cholesterol (HDL-C). The modification of gut microbiota was associated with changes in clinical parameters involved in the development of coronary artery disease (CAD) in CCS patients.

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Section: Discussionmentioning

confidence: 99%

Association of gut microbiota with dyslipidemia and chronic coronary syndrome patients undergoing coronary angiography

Luangphiphat,

Prombutara,

Muangsillapasart

et al. 2023

Preprint

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“…CVD refer to circulatory system disorders, including strokes and myocardial infarction. Environmental and genetic factors also contribute to coronary artery disease (CAD) as a chronic inflammatory condition [59]. Age raises the chance of CVD as a standalone risk factor, especially if other comorbidities such as frailty, diabetes, and obesity accompany it [110].…”

Section: Cvdmentioning

confidence: 99%

“…Higher levels of the phyla Actinobacteria and lower levels of the Bacteroidetes were observed in patients with ACVD [63]. Bouzid et al [59] stated that the same global core oral microbiome represents oral microbial communities in healthy individuals and patients. They found the most prevalent phyla to include Actinobacteria, Firmicutes, Bacteroidetes, Fusobacteria, TM7, and Proteobacteria.…”

Section: Cvdmentioning

confidence: 99%

“…They found the most prevalent phyla to include Actinobacteria, Firmicutes, Bacteroidetes, Fusobacteria, TM7, and Proteobacteria. They reported similar core bacterial members of the oral microbiota in both groups and different distributions of the genus Eikenella in patients with CAD compared to the controls [59]. Periodontal pathogens, therefore, appear to be related to the incidence of cardiovascular disorders.…”

Section: Cvdmentioning

confidence: 99%

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Interactions between systemic diseases and oral microbiota shifts in the aging community: A narrative review

Mosaddad,

Mahootchi,

Safari

et al. 2023

J Basic Microbiol

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As a gateway to general health and a diverse microbial habitat, the oral cavity is colonized by numerous microorganisms such as bacteria, fungi, viruses, and archaea. Oral microbiota plays an essential role in preserving oral health. Besides, the oral cavity also significantly contributes to systemic health. Physiological aging influences all body systems, including the oral microbial inhabitants. The cited effect can cause diseases by forming dysbiotic communities. Since it has been demonstrated that microbial dysbiosis could disturb the symbiosis state between the host and the resident microorganism, shifting the condition toward a more pathogenic one, this study investigated how the oral microbial shifts in aging could associate with the development or progression of systemic diseases in older adults. The current study focused on the interactions between variations in the oral microbiome and prevalent diseases in older adults, including diabetes mellitus, Sjögren's syndrome, rheumatoid arthritis, pulmonary diseases, cardiovascular diseases, oral candidiasis, Parkinson's disease, Alzheimer's disease, and glaucoma. Underlying diseases can dynamically modify the oral ecology and the composition of its resident oral microbiome. Clinical, experimental, and epidemiological research suggests the associations of systemic disorders with bacteremia and inflammation after oral microbial changes in older adults.

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“…The oral microbiome is an ecosystem composed of many different microorganisms. Bouzid et al [19] conducted a metagenomic study of the saliva microbiome using next-generation 16S ribosomal RNA (rRNA) sequencing techniques. They used oral microbiome profiling among 20 people with CAD and among 10 people without atherosclerotic plaques in the carotid arteries, but after stroke or myocardial infarction.…”

Section: Oral Dysbiosismentioning

confidence: 99%

Oral microbial dysbiosis in cardiovascular diseases

Osiak,

Wołowiec,

Żukow

et al. 2023

J Educ Health Sport

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The most common diseases in humans are oral infections. Although modern research is mainly concerned with the role of the gut microbiota in systemic diseases, there are also reports indicating that oral infections, and especially periodontal infection, are one of the risk factors for atherosclerotic cardiovascular disease (CVD).The composition of the oral biofilm is a community of several hundred species of bacteria, fungi, spirochetes, viruses and protozoa. It varies depending on the state of health and disease. Pathogenic bacteria in the oral cavity can cause systemic disease by entering the bloodstream or by triggering immune responses at the cellular level. The discovery of the role of the oral microbiome in CVD is leading to new methods of prevention and their treatment. In this review, we discuss the various mechanisms by which oral dysbiosis may contribute to the pathogenesis of CVD as well as available options for their prevention and treatment. Oral dysbiosis, or the imbalance of bacteria in the oral cavity, has been linked to an increased risk of CVD. Several mechanisms have been proposed to explain how oral dysbiosis may contribute to CVD, including: The production of inflammatory molecules by oral bacteria. The activation of the immune system, which can lead to inflammation throughout the body. The entry of oral bacteria into the bloodstream, where they can travel to other organs and tissues. There are a number of things that can be done to prevent oral dysbiosis and reduce the risk of CVD, including: Good oral hygiene, such as brushing and flossing twice a day. Regular dental checkups and cleanings. Avoiding tobacco use. Eating a healthy diet. Conclusions. The evidence is growing that oral dysbiosis is a risk factor for CVD. Further research is needed to better understand the mechanisms involved and to develop effective interventions for prevention and treatment. The following are some other important points: The role of oral dysbiosis in CVD is likely to be complex and involve multiple factors. The effects of oral dysbiosis on CVD may vary depending on the individual's overall health status and other risk factors. More research is needed to determine the optimal methods for preventing and treating oral dysbiosis in order to reduce the risk of CVD.

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A potential oral microbiome signature associated with coronary artery disease in Tunisia

Cited by 11 publications

References 45 publications

Association of gut microbiota with dyslipidemia and chronic coronary syndrome patients undergoing coronary angiography

Association of gut microbiota with dyslipidemia and chronic coronary syndrome patients undergoing coronary angiography

Interactions between systemic diseases and oral microbiota shifts in the aging community: A narrative review

Oral microbial dysbiosis in cardiovascular diseases

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