A potential marker of bare metal stent restenosis: monocyte count - to- HDL cholesterol ratio

Uçar, Fatih Mehmet

doi:10.1186/s12872-016-0367-3

Cited by 52 publications

(39 citation statements)

References 32 publications

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“…In another study, in patients with acute ST-segment elevation myocardial infarction (STEMI), MHR values at admission were independently correlated with in-hospital adverse cardiovascular events and stent thrombosis and mortality [31]. In two different studies MHR values were found to be in relation with in-stent restenosis [32,33]; also MHR was found to be correlated with presence and severity of ectasia [13].…”

Section: Discussionmentioning

confidence: 98%

Association between monocyte to HDL cholesterol ratio and mitral annulus calcification

Pamukcu¹,

Aker²

2019

Journal of Surgery and Medicine

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Aim: Mitral annulus calcification (MAC) is characterized by degenerative calcification of the mitral valve annulus, MAC and atherosclerosis are similar in regard to risk factors and pathogenesis. Monocyte count to high density lipoprotein (HDL) cholesterol ratio (MHR) is an inflammatory marker that is associated with several atherosclerotic diseases. We aimed to show the association of MHR levels with the presence of MAC. Methods: This retrospective cohort study was conducted with MAC (+) patients who admitted to our echocardiography laboratory which constituted the study group (n=200) and MAC (-) patients which constituted the control group. Demographic features like age and sex, presence of hypertension and diabetes mellitus were similar between groups. Laboratory and echocardiographic parameters were recorded and evaluated for statistical analysis. Results: When groups were compared according to echocardiographic parameters; left atrial diameter, pulmonary artery systolic pressure (PASP) were found to be positively correlated with the presence of MAC (r=0.271, p<0.001; r=0.329, p<0.001, respectively). MHR was significantly higher in study group {15.3 (11.9-20.6) vs. 10.8 (8.6-16.9) p<0.001}. In correlation analysis, MHR value was found to be positively correlated with presence of MAC (r=0.273; p <0.001). Conclusion: We found that the presence of MAC was associated with higher MHR, and MHR was significantly correlated with MAC.

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Section: Discussionmentioning

confidence: 98%

Association between monocyte to HDL cholesterol ratio and mitral annulus calcification

Pamukcu¹,

Aker²

2019

Journal of Surgery and Medicine

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“…Notably, the preprocedural values of MHR and CRP levels were higher in in-stent restenosis than non-in-stent restenosis patients with stable or unstable angina pectoris after bare-metal stent implantation and MHR (HR, 1.09; 95% CI, 1.04-1.14). The latter was an independent predictor of in-stent restenosis in addition to high CRP and uric acid (a marker of oxidative stress; Ucar, 2016).…”

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confidence: 99%

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Ganjali

Gotto

Ruscica

et al. 2018

Journal Cellular Physiology

207

188

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Inflammation and lipid accumulation are two basic hallmarks of atherosclerosis as a chronic disease. Inflammation not only is a local response but can also be considered as a systemic process followed by an elevation of inflammatory mediators. Monocytes are a major source of proinflammatory species during atherogenesis. In atherosclerosis, modified low-density lipoproteins (LDLs) are removed by macrophages; these are recruited in the vessel wall, inducing the release of inflammatory cytokines in inflamed tissue. Hence, inflammatory cholesterol ester-loaded plaque is generated. High-density lipoprotein-cholesterol (HDL-C) exhibits antiatherosclerotic effects by neutralizing the proinflammatory and pro-oxidant effects of monocytes via inhibiting the migration of macrophages and LDL oxidation in addition to the efflux of cholesterol from these cells. Furthermore, HDL plays a role in suppressing the activation of monocytes and proliferation-differentiation of monocyte progenitor cells. Thus, accumulation of monocytes and reduction of HDL-C may participate in atherosclerosis and cardiovascular diseases (CVD). Given that the relationship between the high number of monocytes and low HDL-C levels has been reported in inflammatory disorders, this review focused on understanding whether the monocyte-to-HDL ratio could be a convenient marker to predict atherosclerosis development and progression, hallmarks of CV events, instead of the individual monocyte count or HDL-C level.

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“…MHR is investigated as a novel inflammatory marker and suggested to be superior to WBC subtypes in patients with cardiovascular and cerebrovascular diseases (19,20). Monocytes are inflammatory reaction markers responsible of release of proinflammatory and prooxidant cytokins (21).…”

Section: Discussionmentioning

confidence: 99%

Monocyte to HDL ratio as an indicator of subclinical atherosclerosis in diabetic retinopathy

Kan

Karaibrahimoğlu

2020

Journal of Health Sciences and Medicine

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Amaç: Diyabetik retinopatisi olan hastalarda kardiyovasküler hastalıkların artan sıklığı bilinmektedir. MHO (Monosit/HDL oranı), kardiyovasküler ve serebrovasküler hastalıklarla ilişkisi yeni saptanmış bir belirteçtir. Bu çalışmanın amacı aşikar kardiyovasküler hastalık bulgusu olmayan diyabetik retinopatisi olan hastalarda subklinik ateroskleroz risk göstergesi karotis intima media kalınlığı (KİMK) ile MHO ilşkisini araştırmaktır. Gereç ve Yöntem: Aşikar kardiyovasküler hastalığı olmayan 106 diyabetik hasta ve 35 yaş, cinsiyet ve BMI (body mass index) ile uyumlu sağlıklı kontrol alındı. Hastalar proliferatif diyabetik retinopati (PDR, n=30), nonproliferatif diyabetik retinopati (NPDR, n=35), retinopati olmayan diyabet hastaları (n=41) ve kontrol grubu (n=35) olmak üzere dört gruba ayrıldı. Antropometrik, biyokimyasal parametreler ve KİMK ölçüldü. MHO ile KİMK arasındaki ilişkiyi değerlendirmek için korelasyon ve regresyon analizi yapıldı. Bulgular: MHO değerleri gruplar arasında anlamlı farklılığa sahip ve PDR grubunda anlamlı düzeyde daha yüksekti (p<0.001). Ateroskleroz göstergesi olan KİMK gruplar arasında anlamlı farklılık gösterdi (p<0.001). KİMK değeri PDR grubunda anlamlı düzeyde yüksek iken diğer gruplarda birbirine yakın değerler ölçüldü. PDR grubunda MHO ile KİMK arasında önemli düzeyde anlamlı korelasyon bulundu (r=0,96; p<0.001). Binary logistic regression analizinde MHO'nin KİMK üzerine anlamlı etkisi bulunmaktaydı [β=0,206, (%95 CI: 1,004-1,505), p=0,046]. Sonuç: Bu çalışma, yüksek MHO'nın diyabetik retinopatisi olan hastalarda subklinik kardiyovasküler riski belirlemede non-invaziv, basit ve maliyeti düşük bir marker olarak kullanılabileceğini göstermektedir. Diyabetik retinopatide MHO ve KİMK arasındaki ilişkiyi inceleyen literatürdeki ilk çalışma olan bu çalışma, aşikar kardiyovasküler hastalık bulgusu olmayan diyabetik hastalardaki kardiyak riski erken belirlemede fayda sağlayabilir.

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A potential marker of bare metal stent restenosis: monocyte count - to- HDL cholesterol ratio

Cited by 52 publications

References 32 publications

Association between monocyte to HDL cholesterol ratio and mitral annulus calcification

Association between monocyte to HDL cholesterol ratio and mitral annulus calcification

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Monocyte to HDL ratio as an indicator of subclinical atherosclerosis in diabetic retinopathy

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