A potential link of oxidative stress and cell cycle regulation for development of endometriosis

Shinmoto, Hiroshi; Higashiura, Yumi; Kajihara, Hirotaka; Kobayashi, Hiroshi

doi:10.3109/09513590.2012.683071

Cited by 36 publications

(30 citation statements)

References 55 publications

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“…Therefore, elucidating the detailed association between HNF1B upregulation and the acquisition of cell cycle regulation under conditions of oxidative stress may improve understanding of the mechanisms used to repair DNA damage (7). A previous study identified the role of the HNF1B-mediated signaling pathway in a fail-safe mechanism for the oxidative stress-induced DNA damage response (10). The present study identified six genes, F-Box protein 5 (11,12), Cdk5 and Abl enzyme substrate 1 (13), hepatitis A virus cellular receptor 1 (HAVCR1) (14), cyclin E1 (15), tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, θ (16) and TPD52 (17,18), associated with regulation of the cell cycle regulation that are abnormally expressed in ovarian clear cell carcinoma.…”

Section: Overexpression Of Genes and Their Transcripts In Ovarian Clementioning

confidence: 99%

Novel biomarker candidates for the diagnosis of ovarian clear cell carcinoma

et al. 2015

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Abstract. Ovarian clear cell carcinoma can arise from endometriosis; however, it is distinct from other types of epithelial ovarian carcinoma in terms of its clinicopathological and molecular features. Cancer antigen 125 lacks the sensitivity and specificity required for accurate clinical diagnosis of clear cell carcinoma. Therefore, the aim of the current review was to identify novel biomarker candidates for the immunohistochemical and serological diagnosis of clear cell carcinoma. A search of the relevant English language literature published between 1966 and 2014 was conducted using the PubMed MEDLINE online database. High-throughput tissue microarray technology and proteomic screening combined with mass spectrometry may provide additional information regarding diagnostic biomarker candidates for ovarian clear cell carcinoma. The present review summarizes the characteristics of potential genomic alterations that activate cancer signaling pathways and, thus, contribute to carcinogenesis. The major signaling pathways activated in clear cell carcinoma are associated with cell cycle regulation (hepatitis A virus cellular receptor 1 and tumor protein D52), growth factor signaling (insulin-like growth factor binding protein 1; KiSS-1 metastasis-suppressor; erb-b2 receptor tyrosine kinase 2; and fibroblast growth factor receptor 2), anti-apoptosis and survival pathways [sialidase 3 (membrane sialidase)], metabolism (γ-glutamyltransferase 1), chemoresistance (napsin A aspartic peptidase, glutathione peroxidase 3; and aldehyde dehydrogenase 1 family, member A1), coagulation [coagulation factor III (thromboplastin, tissue factor); and tissue factor pathway inhibitor 2], signaling (lectin, galactoside-binding and soluble, 3), and adhesion and the extracellular matrix [cadherin 1, type 1, E-cadherin (epithelial); versican; and laminin, α 5]. The present review of the relevant literature may provide a basis for additional clinical investigation of the ovarian clear cell carcinoma serum biomarker candidate proteins identified herein.

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Section: Overexpression Of Genes and Their Transcripts In Ovarian Clementioning

confidence: 99%

Novel biomarker candidates for the diagnosis of ovarian clear cell carcinoma

et al. 2015

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“…Recent biochemical and immunohistochemical studies have noted a specific expression of HNF-1β in CCC and genetic alteration may be involved in oxidative stress (2)(3)(4). The majority of the CCC-specific genes were associated with the redox-related genes (2).…”

Section: Proposed Function Of Cd44v9mentioning

confidence: 99%

“…These genes have been hypothe sized as key drivers of the phenotypic characteristics. Recent reviews have demonstrated the function of this molecule in the endometriosis and ovarian cancer (2)(3)(4).…”

Section: The Profiles Of Hnf-1β Target Genesmentioning

confidence: 99%

“…Accumulating evidence indicates that selective genetic alterations play a role in the pathogenesis of endometriosis. Upregulation of transcription factor hepatocyte nuclear factor (HNF)-1β expression occurs in endometriosis (1)(2)(3)(4). However, to what extent HNF-1β overexpression is involved in its pathogenesis remains to be determined.…”

Section: Introductionmentioning

confidence: 99%

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Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis

et al. 2012

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Abstract. Endometriosis is associated with pelvic pain and female infertility. Endometriosis induces inflammation and is vulnerable to oxidative stress damage. To update and summarize the literature concerning the mechanisms that serve to protect genomic DNA from the oxidative damage, the present study reviews the English-language literature for biochemical studies on the transcription factor hepatocyte nuclear factor (HNF)-1β target genes. Findings demonstrated that retrograde flow of the menstrual blood might give rise to endometriosis.

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“…11,15 Interestingly, iron-induced reactive oxygen species (ROS) signaling participates in endometriotic cell survival possibly by acting in detoxification and anti-apoptotic pathways through overexpression of HNF-1β. 16,17 However, little is known about the association between HNF-1β expression and inflammatory cytokines, such as NF-κB, in the endometriosis-OCCC sequence. Moreover, the detailed mechanisms that govern HNF-1β-mediated modulation of cell kinetics, including cell proliferation and apoptosis, in OCCCs remain to be clarified.…”

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confidence: 99%

Transcriptional upregulation of HNF-1β by NF-κB in ovarian clear cell carcinoma modulates susceptibility to apoptosis through alteration in bcl-2 expression

Suzuki

Kajita

Takahashi

et al. 2015

Laboratory Investigation

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Hepatocyte nuclear factor-1β (HNF-1β) is a transcriptional factor that has an important role in endometriosis-ovarian clear cell carcinoma (OCCC) sequence by modulating cell kinetics and glucose metabolism. However, little is known about the detailed molecular mechanisms that govern its regulation and function. Herein, we focus on upstream and downstream regulatory factors of HNF-1β in OCCCs. In clinical samples, HNF-1β expression was positively correlated with the active form of NF-κB/p65 in OCCCs, and closely linked with a low nuclear grade and non-solid architecture. In cell lines, transfection of p65 resulted in increased HNF-1β mRNA and protein expression in TOV-21G cells (OCCC cell line with endogenous HNF-1β expression), in line with activation of the promoter, probably through interacting with the basic transcriptional machinery. Suppression of endogenous HNF-1β expression by siRNA increased apoptosis in TOV-21G cells, while treatment of Hec251 cells (endometrial carcinoma cell line with extremely low endogenous HNF-1β expression) stably overexpressing exogenous HNF-1β with doxorubicin abrogated apoptosis of the cells, along with increased ratio of bcl-2 relative to bax. Moreover, overexpression of HNF-1β led to upregulation of bcl-2 expression at the transcriptional level in TOV-21G cells, which provided evidence for a positive correlation between HNF-1β and bcl-2 expression in OCCCs. These data, therefore, suggest that association between HNF-1β and NF-κB signaling may participate in cell survival by alteration of apoptotic events, particularly in mitochondria-mediated pathways, through upregulation of bcl-2 expression in OCCCs.Laboratory Investigation (2015) 95, 962-972;

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A potential link of oxidative stress and cell cycle regulation for development of endometriosis

Abstract: HNF-1β in endometriosis might be a factor that controls the cell cycle and DNA damage checkpoints.

Cited by 36 publications

References 55 publications

Novel biomarker candidates for the diagnosis of ovarian clear cell carcinoma

Novel biomarker candidates for the diagnosis of ovarian clear cell carcinoma

Hepatocyte nuclear factor (HNF)-1β and its physiological importance in endometriosis

Transcriptional upregulation of HNF-1β by NF-κB in ovarian clear cell carcinoma modulates susceptibility to apoptosis through alteration in bcl-2 expression

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