A potential impact of Helicobacter pylori -related galectin-3 in neurodegeneration

Boziki, Marina; Polyzos, Stergios A.; Deretzi, Georgia; Kazakos, Evangelos; Katsinelos, Panagiotis; Doulberis, Michael; Kotronis, Georgios; Giartza-Taxidou, Evangelia; Laskaridis, Leonidas; Tzivras, Dimitri; Vardaka, Elisabeth; Kountouras, Constantinos; Grigoriadis, Nikolaos; Thomann, Robert V.; Kountouras, Jannis

doi:10.1016/j.neuint.2017.12.003

Cited by 25 publications

(16 citation statements)

References 223 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been shown that Gal3 can be easily detected using an ELISA test 32 , which makes it easily accessible to most practicing clinicians, and greater adoption is expected. Several previous studies showed that Gal3 has a similar positive correlation with cognitive impairment 17,33,34 . In a cross-sectional study, it was found that AD patients have higher serum Gal3 level compared with the controls 18 .…”

Section: Discussionmentioning

confidence: 82%

Prevalence of mild cognitive impairment in type 2 diabetes mellitus is associated with serum galectin‐3 level

et al. 2020

J of Diabetes Invest

View full text Add to dashboard Cite

Aims/Introduction Galectin‐3 (Gal3) contributes to insulin resistance, inflammation and obesity, the three risk factors for mild cognitive impairment (MCI) in type 2 diabetes mellitus patients. Materials and methods A total of 134 hospitalized type 2 diabetes mellitus patients were assessed by the Montreal Cognitive Assessment method, and divided into 65 MCI and 69 controls. Levels of variables, Gal3 and Aβ42, were investigated in relation with cognitive function in both type 2 diabetes mellitus patients with MCI and high‐fat diet/streptozotocin induced type 2 diabetes mellitus rats. Results Significantly higher levels of serum Gal3 and lower levels of plasma Aβ42 (all P < 0.05) were found in the MCI type 2 diabetes mellitus group as compared with the non‐MCI type 2 diabetes mellitus control. Partial correlation analysis showed that Gal3 is negatively correlated with both MMSE score (r = −0.51, P < 0.01) and Montreal Cognitive Assessment score (r = −0.47, P < 0.001) after adjustment for glycated hemoglobin, homoeostasis model assessment of insulin resistance and Aβ42 in all type 2 diabetes mellitus patients, with a stronger effect seen in the MCI type 2 diabetes mellitus group after further analysis with MCI strata. A simple logistic regression model showed that Gal3 and Aβ42 are significantly associated with MCI type 2 diabetes mellitus patients after adjustment with the covariates sex, age, body mass index, glycated hemoglobin, homoeostasis model assessment of insulin resistance and antidiabetic drugs. Serum and brain Gal3 levels were significantly increased in high‐fat diet/streptozotocin diabetic rats, which correlate to the impairment of learning and memory ability. Gal3 inhibitor modified citrus pectin decreased serum and brain Gal3 levels in diabetic rats, accompanied by the amelioration of learning and memory impairment. Conclusions Gal3 might be associated with cognitive impairment in type 2 diabetes mellitus, and serum Gal3 level might be a new risk factor of MCI in type 2 diabetes mellitus patients.

show abstract

Section: Discussionmentioning

confidence: 82%

Prevalence of mild cognitive impairment in type 2 diabetes mellitus is associated with serum galectin‐3 level

et al. 2020

J of Diabetes Invest

View full text Add to dashboard Cite

show abstract

“… 25 Moreover, MCP inhibits Gal3 function to reduce atherosclerotic lesions, which are common in T2DM patients. 26 Several recent studies have shown a similar positive correlation between Gal3 and cognitive impairment, 5 , 27 , 28 while the underlying mechanisms have yet to be clarified. In addition, no studies have shown an association between Gal3 and diabetes-associated cognitive impairment.…”

Section: Discussionmentioning

confidence: 93%

<p>Pharmacological Inhibition of Galectin-3 Ameliorates Diabetes-Associated Cognitive Impairment, Oxidative Stress and Neuroinflammation in vivo and in vitro</p>

Yin¹,

Chen²,

Ma³

et al. 2020

JIR

View full text Add to dashboard Cite

Background In diabetes, cognitive impairment is linked with oxidative stress and neuroinflammation. As the only chimeric member of the galectin family, galectin-3 (Gal3) induces neuroinflammation and cognitive impairment in models of Alzheimer’s disease (AD); however, its role in diabetes-associated cognitive impairment is not established. Methodology Here, we investigated the effects of Gal3 inhibition on cognitive impairment and the possible underlying molecular events in diabetes. We investigated the effects of the Gal3 inhibitor modified citrus pectin (MCP; 100 mg/kg/day oral for 6 weeks) in vivo in high-fat diet (HFD)/streptozotocin (STZ)-induced diabetic rats. Additionally, the effects of MCP on high glucose (HG)-stimulated BV-2 microglial cells were investigated in vitro. Results We found that MCP attenuated memory impairment in diabetic rats in the Morris water maze test and reduced insulin resistance, oxidative stress, and neuroinflammation. In HG-stimulated BV-2 microglial cells, MCP increased cell viability and decreased oxidative stress and the production of proinflammatory cytokines. Conclusion The results of this study indicate that the inhibition of Gal3 by MCP ameliorates diabetes-associated cognitive impairment, oxidative stress, and neuroinflammation, suggesting that Gal3 could be a potential new target for therapeutic intervention to prevent cognitive impairment in diabetes.

show abstract

“…For instance, in Helicobacter pylori infection of the wild type (WT) mice bacterial cells were restricted to the surface of the gastric mucosa, while in the Galectin-3 deficient mice bacterial cells penetrated deep within the gastric glands [38]. Boziki and colleagues reviewed the interaction between Helicobacter pylori infection mediated Galectin-3 up-regulation and neurodegeneration [39]. The authors presented various steps in cascade of neurodegeneration such as: common contribution of Helicobacter pylori mediators and Galectin-3 in disruption of blood-brain barrier, Helicobacter pylori induced increase of Galectin-3 expression in CNS, compromised phagocytic activity of macrophages, triggering production of cytokines involved in pathogenesis of neurodegenerative diseases and other toxic agents [39].…”

Section: Galectin-3 Ligands and Pattern Recognition Receptors In The Cnsmentioning

confidence: 99%

Galectin-3: Roles in Neurodevelopment, Neuroinflammation, and Behavior

et al. 2020

View full text Add to dashboard Cite

There is a plethora of evidence to suggest that Galectin-3 plays an important role in normal functions of mammalian cells, as well as in different pathogenic conditions. This review highlights recent data published by researchers, including our own team, on roles of Galectin-3 in the nervous system. Here, we discuss the roles of Galectin-3 in brain development, its roles in glial cells, as well as the interactions of glial cells with other neural and invading cells in pathological conditions. Galectin-3 plays an important role in the pathogenesis of neuroinflammatory and neurodegenerative disorders, such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. On the other hand, there is also evidence of the protective role of Galectin-3 due to its anti-apoptotic effect in target cells. Interestingly, genetic deletion of Galectin-3 affects behavioral patterns in maturing and adult mice. The results reviewed in this paper and recent development of highly specific inhibitors suggests that Galectin-3 may be an important therapeutic target in pathological conditions including the disorders of the central nervous system.

show abstract

A potential impact of Helicobacter pylori -related galectin-3 in neurodegeneration

Cited by 25 publications

References 223 publications

Prevalence of mild cognitive impairment in type 2 diabetes mellitus is associated with serum galectin‐3 level

Prevalence of mild cognitive impairment in type 2 diabetes mellitus is associated with serum galectin‐3 level

<p>Pharmacological Inhibition of Galectin-3 Ameliorates Diabetes-Associated Cognitive Impairment, Oxidative Stress and Neuroinflammation in vivo and in vitro</p>

Galectin-3: Roles in Neurodevelopment, Neuroinflammation, and Behavior

Contact Info

Product

Resources

About