A Potential Antithrombotic Trick for an Old Drug: Quinine Inhibits the Binding of Antiphospholipid Antibody-β2-Glycoprotein I Immune Complexes to Phospholipid Bilayers in Vitro
Abstract:3423
Background:
Quinine, an old drug extracted from bark of the cinchona tree, was the first effective antimalarial. Hydroxychloroquine (HCQ), a synthetic antimalarial developed over 60 years ago was subsequently found to be effective for treating autoimmune disorders and is widely used to treat systemic lupus erythematosus (SLE). Observational clinical studies have indicated that HCQ is associated with reduced risk of thrombosis in SLE and the antiphospholi… Show more
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