A potent physiological method to magnify and sustain soleus oxidative metabolism improves glucose and lipid regulation

Hamilton, Marc T.; Hamilton, Deborah G.; Zderic, Theodore W.

doi:10.1016/j.isci.2022.104869

Cited by 13 publications

(21 citation statements)

References 105 publications

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“…Further, the soleus has distinctive vascular features which enhance the delivery of blood-borne fuels and oxygen ( McDonough et al, 2005 ). Hamilton, Hamilton ( Hamilton et al, 2022 ) found that using leg fidgeting in a seated position for a 3-h period, very low-density lipoprotein (VLDL) plasma concentrations were significantly reduced. While VLDLs were not assessed in this study, triglyceride concentration was 32% lower in the HFF compared to the HF trial, and so it may in part explain an attenuated cellular response that underpins endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…One potential interruption strategy which may be behaviourally acceptable could be the use of localized isolated plantarflexion activity. Localized isolated plantarflexion activity in this case, is defined as leg fidgeting, and has been shown to be a potent method for: improving systemic metabolic regulation, very low-density lipoproteins triglyceride concentrations ( Hamilton et al, 2022 ), reducing venous pooling in the lower limbs (a potential key driver of sitting induced vascular dysfunction) ( Credeur et al, 2019 ), improving lower limb endothelial function ( Morishima et al, 2016 ), and improving cerebral oxygenation and cognition ( Fryer et al, 2022 ). What is not known is whether leg fidgeting can attenuate the impairment in central and peripheral vascular function following the combination of a HF meal consumption and prolonged uninterrupted sitting.…”

Section: Introductionmentioning

confidence: 99%

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Localized activity attenuates the combined impact of a high fat meal and prolonged sitting on arterial stiffness: A randomized, controlled cross-over trial

et al. 2023

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Exposure to acute prolonged sitting and consumption of a high fat (HF) meal have been shown to independently and additively impair central and peripheral cardiovascular function. This study sought to determine whether localized activity, namely leg fidgeting, offers a protective effect to these deleterious effects. Using a randomized crossover design with three trials, 18 healthy males sat uninterrupted for 180 min following the consumption of a low fat (LF, trial 1) or HF meal (trial 2). The third trial consisted of a HF meal but sitting was interrupted with 1 min of leg fidgeting (isolated bilateral plantar flexion) consisting of −250 taps per min every 5 min for the 180 min duration. Carotid-femoral pulse wave velocity (cfPWV), aortic-femoral stiffness gradient (af-SG), superficial femoral blood flow, shear-rate and PWVβ, triglyceride concentrations and lower-limb venous pooling (HHb) were assessed pre and post sitting in all trials. General linear mixed model found that following the uninterrupted HF trial, there was a significant worsening of cfPWV (mean difference (MD) = 0.57 mˑs−1; d = 1.04) and the af-SG (MD = 0.14, d = 0.50), and femoral artery blood flow (MD = 18 mlˑmin−1; d = 0.48) and shear rate (MD = 15 S1; d = 0.67) decreased. However, leg fidgeting was enough to prevent the combined deleterious effects of prolonged sitting following a HF meal. As there were no significant changes in the LF trial, the HF meal maybe the predominant driver when uninterrupted sitting is combined with a HF meal.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Localized activity attenuates the combined impact of a high fat meal and prolonged sitting on arterial stiffness: A randomized, controlled cross-over trial

et al. 2023

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“…[50] Effective physical activity for reducing PPHG includes low-intensity regimes such as walking but can also be as modest as ''soleus push-ups '' while seated. [51] Counter-intuitively, cessation of smoking is often associated with worsening insulin resistance and worsening PPHG, with an increased risk of type II DM. [52] This occurs during the initial months following smoking abstinence and appears to be, partially at least, secondary to dietary changes and weight gain experienced by many individuals who stop smoking.…”

Section: Methods For Reducing Post-prandial Hyperglycemiamentioning

confidence: 99%

Continuous Glucose Monitoring in a Healthy Population: Understanding the Post-Prandial Glycemic Response in Individuals without Diabetes Mellitus

Jarvis¹,

Cardin²,

Bede³

et al. 2023

Preprint

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Continuous glucose monitoring has become a common adjunct in the management of Diabetes Mellitus. However, there has been a recent trend among individuals without diabetes using these devices as a means of monitoring their health. The increased visibility of glucose data has allowed users to study the effect lifestyle has upon post-prandial glucose levels. Although post-prandial hyperglycemia is well understood in the setting of diabetes, its impact in individuals without diabetes is less well defined. This article reviews those factors which contribute to post-prandial hyperglycemia in individuals without diabetes and how the data obtained from continuous glucose monitoring can be used to improve an individual’s metabolic health.

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“…As a powerful and slow oxidative muscle, the soleus muscle is active with virtually all types of weight-bearing activities and equipped with the molecular mechanism for regulating blood-borne substrates. 31 Therefore, the acquisition of high-flux electromyography (EMG) signals of the soleus muscle can effectively advance our understanding of it. Nevertheless, due to the limitation of the current medical methods, we can only monitor the muscle with a singlechannel electrode (as shown in the blue frame of Figure 5b).…”

Section: Mechanism and Design Principle Of The Topologicalmentioning

confidence: 99%

Topological MXene Network Enabled Mixed Ion–Electron Conductive Hydrogel Bioelectronics

Luo,

Zhang,

Sun

et al. 2024

ACS Nano

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Mixed ion−electron conductive (MIEC) bioelectronics has emerged as a state-of-the-art type of bioelectronics for bioelectrical signal monitoring. However, existing MIEC bioelectronics is limited by delamination and transmission defects in bioelectrical signals. Herein, a topological MXene network enhanced MIEC hydrogel bioelectronics that simultaneously exhibits both electrical and mechanical property enhancement while maintaining adhesion and biocompatibility, providing an ideal MIEC bioelectronics for electrophysiological signal monitoring, is introduced. Compared with nontopology hydrogel bioelectronics, the MXene topology increases the dynamic stability of bioelectronics by a factor of 8.4 and the electrical signal by a factor of 10.1 and reduces the energy dissipation by a factor of 20.2. Besides, the topology-enhanced hydrogel bioelectronics exhibits low impedance (<25 Ω) at physiologically relevant frequencies and negligible impedance fluctuation after 5000 stretch cycles. The creation of multichannel bioelectronics with high-fidelity muscle action mapping and gait recognition was made possible by achieving such performance.

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A potent physiological method to magnify and sustain soleus oxidative metabolism improves glucose and lipid regulation

Cited by 13 publications

References 105 publications

Localized activity attenuates the combined impact of a high fat meal and prolonged sitting on arterial stiffness: A randomized, controlled cross-over trial

Localized activity attenuates the combined impact of a high fat meal and prolonged sitting on arterial stiffness: A randomized, controlled cross-over trial

Continuous Glucose Monitoring in a Healthy Population: Understanding the Post-Prandial Glycemic Response in Individuals without Diabetes Mellitus

Topological MXene Network Enabled Mixed Ion–Electron Conductive Hydrogel Bioelectronics

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