A Potent Pancreatic Carcinogen in Syrian Hamsters: N-Nitrosobis(2-oxopropyl)amine2

Pour, Parviz M.; Althoff, J.; Krüger, Friedrich; Möhr, U.

doi:10.1093/jnci/58.5.1449

Cited by 149 publications

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“…BOP is a potent carcinogen in the biliary tract and pancreas of hamsters (23). BOP-induced biliary carcinoma shows a histological resemblance to carcinoma in humans (22) and has thus made it possible to observe various early stage lesions which are often difficult to observe in humans (21,24).…”

Section: Discussionmentioning

confidence: 99%

Interleukin-6 Expression on the Biliary Epithelia During Inflammation-Associated Biliary Carcinogenesis in Bilioenterostomized Hamsters

Kitajima¹,

Tajima²,

Kuroki³

et al. 2010

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Interleukin-6 Expression on the Biliary Epithelia During Inflammation-Associated Biliary Carcinogenesis in Bilioenterostomized Hamsters

Kitajima¹,

Tajima²,

Kuroki³

et al. 2010

Journal of Surgical Research

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“…Therefore, the ideal experimental model for pancreatic carcinoma should provide tumors of histologic type resembling human pancreatic carcinoma. As to induction of carcinoma originated from the pancreatic duct, Pour et al (1977) reported favorable results obtained by giving N-nitrosobis (2-oxopropyl) amine (BOP) to Syrian Golden hamsters. Dissin et al (1975) and Satake et al (1975) who embedded DMBA directly into the pancreas of SD rats also reported relatively favorable results.…”

Section: Discussionmentioning

confidence: 99%

Effects of immunosuppressive acidic protein on DMBA-induced pancreatic cancer in rats.

Matsuno

Ejiri

Kobari

et al. 1984

Tohoku J. Exp. Med.

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In order to determine the effect of immunosuppressive acidic protein (TAP) on the formation of pancreatic carcinoma, rats of the Sprague-Dawley strain were embedded with 7,12-dimethylbenzanthracene (DMBA) in the pancreas with and without administration of TAP. In these animals, the growth of pancreatic cancer was studied both immunologically and histologically. Tumor was induced in 51 animals (85%) of 60 treated with embedding of 1 mg DMBA alone. Tumors began to appear from the 16th week after the embedding. Among animals in which tumor was induced, tubular adenocarcinoma and pleomorphic carcinoma accounted for 55% of the cases. When administration of TAP was combined, the period required for development of tumor was shortened. It became shorter with increases in the dosage and frequency of administration of TAP. In animals which received TAP in a mean dose of 75 mg/kg the area showing cancerous changes appeared as early as at the 8th week after the embedding of DMBA. A significant increase in the volume of tumors was seen in the group treated with TAP as compared to the group not treated with TAP. Animals which received TAP in increasing doses and frequencies showed an accelecrated increase in the volume of the tumors which underwent cancerous changes. TAP was eliminated from the serum of rats within 72 hr after the administration, and acid protein was clearly recovered from the serum when tumors proliferated. These findings indicate that the acceleration of carcinogenesis in DMBA-induced pancreatic carcinoma may be attributable to the immunosuppressive effect of TAP administered and tend to be dependent on the dosage and frequency of its administration in the early phase of tumor induction.experimental pancreatic cancer ; 7,12-dimethyl benzanthracene ; immunosuppressive acidic proteinAs an approach to the diagnosis and treatment of pancreatic carcinoma, establishment of experimental models of pancreatic carcinoma has been attemped (Druckrey et al. 1968;Pour et al. 1975). Heretofore, few papers have been published describing the preparation of experimental models of pancreatic car-

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“…For investigating the mechanisms of the development of pancreatic cancer, an experimental pancreatic ductal carcinogenesis model has been established with the carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) in hamsters (19)(20)(21)(22). This model provides unique characteristics that are similar to a sequence of well-characterized morphologic changes in the human pancreatic duct and frequently shows point mutations in codon 12 of the K-ras gene, in accordance with human findings (23,24).…”

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confidence: 87%

In Vivo SPECT Imaging with ¹¹¹In-DOTA-c(RGDfK) to Detect Early Pancreatic Cancer in a Hamster Pancreatic Carcinogenesis Model

Yoshimoto¹,

Hayakawa²,

Mutoh³

et al. 2012

J Nucl Med

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Early detection of pancreatic cancer is key to overcoming its poor prognosis. a v b 3 -integrin is often overexpressed in pancreatic tumor cells, whereas it is scarcely expressed in normal pancreatic cells. In this study, we investigated the usefulness of SPECT imaging with 111 In-1,4,7,10-tetraazacylododecane-N,N9,N$,N999-tetraacetic acidcyclo-(Arg-Gly-Asp-D-Phe-Lys) [ 111 In-DOTA-c(RGDfK)], an imaging probe of a v b 3 -integrin, for the early detection of pancreatic cancer in a hamster pancreatic carcinogenesis model. Methods: Hamsters were subcutaneously injected with the pancreatic duct carcinogen N-nitrosobis(2-oxopropyl)amine to induce pancreatic cancer. N-nitrosobis(2-oxopropyl)amine-treated hamsters underwent in vivo SPECT with 111 In-DOTA-c(RGDfK). After imaging, the tumorto-normal pancreatic tissue radioactivity ratios in excised pancreatic samples were measured with autoradiography (ARG) and compared with the immunopathologic findings for a v b 3 -integrin. In a mouse model in which inflammation was induced with turpentine, the uptake of 111 In-DOTA-c(RGDfK) in inflammatory regions was evaluated with ARG and compared with that of 18 F-FDG. Results: 111 In-DOTA-c(RGDfK) was clearly visualized in pancreatic cancer lesions as small as 3 mm in diameter. ARG analysis revealed high tumor-to-normal pancreatic tissue radioactivity ratios (4.6 6 1.0 [mean 6 SD] in adenocarcinoma and 3.3 6 1.4 in atypical hyperplasia). The uptake of 111 In-DOTA-c(RGDfK) strongly correlated with a v b 3 -integrin expression. In the inflammatory model, inflammation-to-muscle ratios for In-DOTA-c(RGDfK) were 8.37 6 4.37 and 1.98 6 0.60, respectively. These results imply that 111 In-DOTA-c(RGDfK) has a lower rate of false-positive tumor detection than 18 F-FDG. Conclusion: Our findings suggest that SPECT with 111 In-DOTA-c(RGDfK) has great potential for the early and accurate detection of pancreatic cancer.

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A Potent Pancreatic Carcinogen in Syrian Hamsters: N-Nitrosobis(2-oxopropyl)amine2

Cited by 149 publications

References 0 publications

Interleukin-6 Expression on the Biliary Epithelia During Inflammation-Associated Biliary Carcinogenesis in Bilioenterostomized Hamsters

Interleukin-6 Expression on the Biliary Epithelia During Inflammation-Associated Biliary Carcinogenesis in Bilioenterostomized Hamsters

Effects of immunosuppressive acidic protein on DMBA-induced pancreatic cancer in rats.

In Vivo SPECT Imaging with ¹¹¹In-DOTA-c(RGDfK) to Detect Early Pancreatic Cancer in a Hamster Pancreatic Carcinogenesis Model

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A Potent Pancreatic Carcinogen in Syrian Hamsters: N-Nitrosobis(2-oxopropyl)amine2

Cited by 149 publications

References 0 publications

Interleukin-6 Expression on the Biliary Epithelia During Inflammation-Associated Biliary Carcinogenesis in Bilioenterostomized Hamsters

Interleukin-6 Expression on the Biliary Epithelia During Inflammation-Associated Biliary Carcinogenesis in Bilioenterostomized Hamsters

Effects of immunosuppressive acidic protein on DMBA-induced pancreatic cancer in rats.

In Vivo SPECT Imaging with 111In-DOTA-c(RGDfK) to Detect Early Pancreatic Cancer in a Hamster Pancreatic Carcinogenesis Model

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In Vivo SPECT Imaging with ¹¹¹In-DOTA-c(RGDfK) to Detect Early Pancreatic Cancer in a Hamster Pancreatic Carcinogenesis Model