A potent multifunctional ZIF-8 nanoplatform developed for colorectal cancer therapy by triple-delivery of chemo/radio/targeted therapy agents

Abstract

Background: The concept of multimodal cancer therapy has garnered significant interest due to its ability to target tumor cells from various perspectives. The advancement of novel nano-delivery platforms represents a...

Enhanced theranostic efficacy of epirubicin-loaded SPION@MSN through co-delivery of an anti-miR-21-expressing plasmid and ZIF-8 hybridization to target colon adenocarcinoma

“…ZIF-8 maintains the functionality of the biomolecule while safeguarding it within its narrow pore size distribution. 20,21 Moreover, the ease of synthesis at room temperature facilitates efficient optimization of plasmid adsorption, and the pH-sensitive nature of ZIF-8 helps the controlled release of the cargo. 22 By combining the unique capabilities of MSNs and ZIF-8, researchers have explored the development of MSN@ZIF-8 coreshell structures.…”