A potent antibiotic-loaded bone-cement implant against staphylococcal bone infections

Ghosh, Sumana; Sinha, M.; Samanta, R.; Sadhasivam, Suresh; Bhattacharyya, Anamika; Nandy, Ashis; Saini, Swamini; Tandon, Nupur; Singh, Himanshi; Gupta, Swati; Chauhan, Anjali; Aavula, Keerthi Kumar; Varghese, Sneha Susan; Shi, Peipei; Ghosh, Sudip Kumar; Garg, Mukesh; Saha, Tanmoy; Padhye, Aparna; Ghosh, Shamik; Jang, Hae Lin; Sengupta, Shiladitya

doi:10.1038/s41551-022-00950-x

Cited by 20 publications

(19 citation statements)

References 44 publications

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“…A novel quinolone antibiotic was developed by Shiladitya Sengupta and colleagues using molecular‐docking simulation, and one lead compound, VCD‐077, was selected based on this strategy 1 . Antimicrobial resistance is increasing, driven by widespread antibiotic overuse in medical and agricultural settings 2 .…”

Section: Figurementioning

confidence: 99%

“…Reporting in Nature Biomedical Engineering, Shiladitya Sengupta and colleagues now show that VCD‐077 screened by molecular‐docking simulations exhibits excellent activity against drug‐resistant bacteria and its biofilms, reduces the development of bacterial resistance and is compatible with bone cement for local delivery and treatment of staphylococcal bone infections in rats (Figure 1). 1 …”

Section: Figurementioning

confidence: 99%

“…A novel quinolone antibiotic was developed by Shiladitya Sengupta and colleagues using molecular-docking simulation, and one lead compound, VCD-077, was selected based on this strategy. 1 Antimicrobial resistance is increasing, driven by widespread antibiotic overuse in medical and agricultural settings. 2 Paradoxically, despite the urgent need to develop a new generation of antibiotics, their marketability is suppressed, partly because the new antibacterial drug may quickly develop new resistance and the development of new antibiotics is sluggish.…”

mentioning

confidence: 99%

“…Reporting in Nature Biomedical Engineering, Shiladitya Sengupta and colleagues now show that VCD-077 screened by molecular-docking simulations exhibits excellent activity against drug-resistant bacteria and its biofilms, reduces the development of bacterial resistance and is compatible with bone cement for local delivery and treatment of staphylococcal bone infections in rats (Figure 1). 1 Bone infections are rising rapidly due to accidental fractures and the global aging population. 5 Sengupta and co-authors designed a series of quinolone antibiotics using molecular-docking simulation.…”

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confidence: 99%

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Targeting staphylococcal bone infections

Zhang

Chen

2023

MedComm – Biomaterials and Applications

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Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Targeting staphylococcal bone infections

Zhang

Chen

2023

MedComm – Biomaterials and Applications

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“…The development of drug-loaded bone cements has been previously studied, with the prevalent approach to mix the drug, in dry powder state, with the solid component of cements (Liu et al, 2010;Bistolfi et al, 2011;Mori et al, 2011;Qin et al, 2015;Cara et al, 2020). However, the development of drug loaded selfhardening apatitic formulations with appropriate injectability, flowability and setting times is widely recognized as a difficult task (Ginebra et al, 2010;Wang et al, 2014;Zhang et al, 2014;Pastorino et al, 2015;O'Neill et al, 2017;Anagnostakos et al, 2022;Ghosh et al, 2022;Hu et al, 2022). For instance, the loading of antibiotic tetracycline (TC) from CPCs was associated to a delaying effect on the hardening and on the rate of formation of the final HA phase (Ratier et al, 2004;Rabiee, 2013).…”

Section: Introductionmentioning

confidence: 99%

Strontium-doped apatitic bone cements with tunable antibacterial and antibiofilm ability

Dapporto

Tavoni

Restivo

et al. 2022

Front. Bioeng. Biotechnol.

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Injectable calcium phosphate cements (CPCs) represent promising candidates for the regeneration of complex-shape bone defects, thanks to self-hardening ability, bioactive composition and nanostructure offering high specific surface area for cell attachment and conduction. Such features make CPCs also interesting for functionalization with various biomolecules, towards the generation of multifunctional devices with enhanced therapeutic ability. In particular, strontium-doped CPCs have been studied in the last years due to the intrinsic antiosteoporotic character of strontium. In this work, a SrCPC previously reported as osteointegrative and capable to modulate the fate of bone cells was enriched with hydroxyapatite nanoparticles (HA-NPs) functionalized with tetracycline (TC) to provide antibacterial activity. We found that HA-NPs functionalized with TC (NP-TC) can act as modulator of the drug release profile when embedded in SrCPCs, thus providing a sustained and tunable TC release. In vitro microbiological tests on Escherichia coli and Staphylococcus aureus strains proved effective bacteriostatic and bactericidal properties, especially for the NP-TC loaded SrCPC formulations. Overall, our results indicate that the addition of NP-TC on CPC acted as effective modulator towards a tunable drug release control in the treatment of bone infections or cancers.

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Ultrasound‐Controlled Electron‐Phonon Coupling Augmenting Catalysis of Piezoelectric‐Based Sonosensitizer Safely Against Osteomyelitis

Zhu

et al. 2023

Adv Funct Materials

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The energy transfer way and efficiency of ultrasound (US) to piezoelectric materials in fluid determines the US catalytic performance of materials and the subsequent sono‐therapeutic effects for deep infection diseases. Herein, on insonation, the microbubble cavitation occurs near the surface of barium orthotitanate/berberine chloride nanoparticles (BTO/Ber NPs), often forming sonoluminescence and high pressure. The light further activates Ber, and the electron transfer happens between activated Ber and changing energy levels of BTO NPs caused by changing pressure. Meanwhile, ultrasound‐driven piezoelectric electron‐phonon coupling simultaneously narrows bandgap and prolongates carrier‐lifetime, leading to more ROS generation. Hence, BTO/Ber NPs show great antibacterial activity against Staphylococcus aureus (99.80 ± 0.09%) by microbubble‐mediated sonoporation and catalysis. Meanwhile, BTO/Ber NPs improve bone regeneration by decreasing the inflammatory response and enhancing osteoblast differentiation. US‐mediated microbubbles may offer a safe and efficient treatment to millions of patients suffering from osteomyelitis and pave the way for the highly safe use of ultrasound in deep infections.

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A potent antibiotic-loaded bone-cement implant against staphylococcal bone infections

Cited by 20 publications

References 44 publications

Targeting staphylococcal bone infections

Targeting staphylococcal bone infections

Strontium-doped apatitic bone cements with tunable antibacterial and antibiofilm ability

Ultrasound‐Controlled Electron‐Phonon Coupling Augmenting Catalysis of Piezoelectric‐Based Sonosensitizer Safely Against Osteomyelitis

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