A postmenopause-like model of ovariectomized Wistar rats to identify active principles of Erythrina lysistemon (Fabaceae)

Mvondo, Marie Alfrede; Njamen, Dieudonné; Fomum, Stephen Tanee; Wandji, Jean; Vollmer, Günter

doi:10.1016/j.fitote.2011.05.009

Cited by 25 publications

(24 citation statements)

References 66 publications

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“…This increase in OVX animals' body weight is in accordance with the previous observations reported in the literature (15,37). Weight gain is the result of complex multifaceted processes, involving particularly the resistance to leptin, a decreased expression of adiponectin and excessive conversion of glucose into fat (41).…”

Section: Fig 4 Effects Of 3-day Treatment Withsupporting

confidence: 91%

Effects of Millettia macrophylla (Fabaceae) Extracts on Estrogen Target Organs of Female Wistar Rat

et al. 2013

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Abstract. The present study aims to determine the estrogenicity of Millettia macrophylla, a Cameroonian medicinal plant, in ovariectomized rats and to investigate the underlying mechanisms, in order to justify scientifically its traditional use. To accomplish this objective, we used dichloromethane (DCM) and methanol (MeOH) extracts of the stem bark of M. macrophylla. In the cell culture based assay, the MeOH extract significantly transactivated estrogen receptor a (ERa) and estrogen receptor b (ERb); in addition, the estrogen-like effects of both, DCM and MeOH extracts, could be inhibited in vitro by the pure ER antagonist ICI 182,780, indicating that these effects were primarily mediated through ERs. In animal experiments, both DCM and MeOH extracts significantly increased the uterine and vaginal epithelial heights in the 3-day treatment assay, while only the MeOH extract exhibited such effects in the sub-chronic treatment regimen. Furthermore, the MeOH extract significantly decreased fasting serum triglycerides, total cholesterol levels and artherogenic risk in the sub-chronic treatment. These results indicate that M. macrophylla extracts have estrogen-like effects supporting their traditional use in

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Section: Fig 4 Effects Of 3-day Treatment Withsupporting

confidence: 91%

Effects of Millettia macrophylla (Fabaceae) Extracts on Estrogen Target Organs of Female Wistar Rat

et al. 2013

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“…Furthermore, alpinumisoflavone and abyssinone V-4′-methyl-ether reduced atherogenic risks by decreasing the two assessed atherogenic parameters, namely, the total cholesterol/HDL-cholesterol ratio and the atherogenic index of plasma in ovariectomized Wistar rats serving as a preclinical model for postmenopausal conditions. In the same study, both compounds were found to decrease serum gonadotrophin levels and to reduce the hot flush activity by increasing the ratio of FSH on LH [19]. Finally, whereas alpinumisoflavone induced clear estrogenic effects both on classical and nonclassical estrogen targets, the flavanone abyssinone V-4′methyl-ether did affect only the vagina (suggesting the safety of treatment with this compound towards the uterus of female rats) and nonclassical estrogen targets such as the lipid metabolism, implying a tissue specific effect.…”

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confidence: 82%

“…In-depth phytochemical studies have already been conducted on some of these plants. As far as the Erythrina lysistemon extract is concerned, following a phytochemical analysis, alpinumisoflavone and abyssinone V-4′-methyl-ether have been isolated as major estrogenic constituents [19,20]. In the same study, alpinumisoflavone (an isoflavone) and abyssinone V-4′-methyl-ether (a flavanone) were found to be responsible for the estrogenic effects of the crude extract of Erythrina lysistemon, as they stimulated uterine growth and/or vaginal proliferation.…”

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confidence: 91%

Phytotherapy and Womenʼs Reproductive Health: The Cameroonian Perspective

et al. 2013

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Approximately 80?% of the population in Africa use traditional medicinal plants to improve their state of health. The reason of such a wide use of medicinal plants has been mainly attributed to their accessibility and affordability. Expectation of little if any side effects, of a ?natural? and therefore safe treatment regimen, as well as traditional beliefs additionally contribute to their popularity. Several of these plants are used by women to relieve problems related to their reproductive health, during or after their reproductive life, during pregnancy, or following parturition. The African pharmacopoeia thus provides plants used for preventing and/or treating gynecological infections, dysmenorrhea, irregular menstruations, oligomenorrhea or protracted menstruation, and infertility. Such plants may then be used as antimicrobians, emmenagogues, or as suppressors of uterine flow. African medicinal plants are also used during pregnancy for prenatal care, against fetal malposition or malpresentation, retained dead fetus, and against threatened abortion. Some others are used as anti-fertilizing drugs for birth control. Such plants may exert various activities, namely, anti-implantation or early abortifacient, anti-zygotic, blastocytotoxic, and anti-ovulatory effects. Some herbs could also act as sexual drive suppressors or as a post-coital contraceptive by reducing the fertility index. A number of these plants have already been subject to scientific investigations and many of their properties have been assessed as estrogenic, oxytocic, or anti-implantation. Taking into account the diversity of the African pharmacopoeia, we are still at an early stage in the phytochemical and pharmacological characterization of these medicinal plants that affect the female reproductive system, in order to determine, through in vitro and in vivo studies, their pharmacological properties and their active principles.

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“…It also possesses antioxidant activity which can lower the risk of lipid peroxidation [16]. Ovariectomized female rats have been used widely as a postmenopausal model [17][18].…”

Section: Introductionmentioning

confidence: 99%