A post-sulfonated one-pot synthesized magnetic cellulose nanocomposite for Knoevenagel and Thorpe–Ziegler reactions

Sayed, Mostafa; Saddik, Abdelreheem Abdelfatah; Kamal El-Dean, Adel M.; Fatehi, Pedram; Soliman, Ahmed I. A.

doi:10.1039/d3ra05439j

RSC Adv.

2023

DOI: 10.1039/d3ra05439j

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A post-sulfonated one-pot synthesized magnetic cellulose nanocomposite for Knoevenagel and Thorpe–Ziegler reactions

Mostafa Sayed,

Abdelreheem Abdelfatah Saddik,

Adel M. Kamal El-Dean

et al.

Abstract: Synthesis of a sulfonated magnetic cellulose nanocomposite to be applied in Knoevenagel and Thrope–Ziegler reactions. The catalyst promotes a sufficient and facile synthesis methodology for obtaining high-yield products.

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2024

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Cited by 3 publications

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Application of Fe₃O₄@MCC Nanoparticles as a Heterogeneous Catalyst for Sustainable Multicomponent Synthesis of 2,3′‐Biindoles

Pandya,

Chaudhari,

Sharma

et al. 2024

ChemCatChem

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Developing innovative methods for synthesizing unique 2,3'‐biindole derivatives is crucial for the progression of drug and material discovery. The use of transition‐metal‐catalyzed coupling improves the efficiency and structural diversity in the synthesis of biindoles. Among these methods, heterogeneous catalysis, particularly using Fe3O4 nanocatalyst supported by microcrystalline cellulose (MCC), is promising for green chemistry applications. In the present work, sixteen 2,3'‐biindole derivatives (4a‐p) were prepared using Fe3O4@MCC nanocatalyst which demonstrated enhanced performance, cost‐effectiveness, and reusability. The magnetic properties of the catalyst enable easy separation, simplifying purification processes, and enhancing overall reaction efficiency to 78%–93%. This method aligns with sustainable chemical practices and offers practical benefits for various industrial applications. This environment friendly method boasts several advantages and demonstrates excellent green chemistry metrics, including process mass intensity, environmental impact factor, atom economy, and reaction mass efficiency, atom economy, carbon efficiency, chemical yield, and optimum efficiency.

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Application of Fe₃O₄@MCC Nanoparticles as a Heterogeneous Catalyst for Sustainable Multicomponent Synthesis of 2,3′‐Biindoles

Pandya,

Chaudhari,

Sharma

et al. 2024

ChemCatChem

View full text Add to dashboard Cite

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Cationic lignin as an efficient and sustainable homogenous catalyst for aqueous Knoevenagel condensation reactions

Soliman,

Bacchus,

Zare

et al. 2024

RSC Adv.

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Anti-inflammatory Activity and Computational Biology Study of Indole/Pyrimidine Hybrids

Sayed,

El-Rashedy

et al. 2024

COC

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This research paper embarks on an interdisciplinary exploration encompassing synthetic chemistry, pharmacology, and computational biology. The development of novel anti-inflammatory agents is an imperative endeavor within pharmaceutical research. Pyrimidines and thienopyrimidines are class of heterocyclic compounds that have gained prominence for their diverse pharmacological properties, including potential anti-inflammatory effects. When augmented with an indole moiety, these compounds exhibit structural diversity that can profoundly influence their biological activities. The integration of computational biology specifically molecular docking, plays a crucial role in predicting and understanding the binding interactions between these compounds and select protein targets associated with inflammatory pathways. This computational approach expedites the screening of potential drug candidates and elucidates the molecular underpinnings of their anti-inflammatory actions. Pyrimidine and thienopyrimidines tethering indole scaffold were obtained according to our reported methods. Subsequently, in vivo evaluation of anti-inflammatory is indispensable to gauge the anti-inflammatory potential of these compounds and establish structure-activity relationships. The experimental and computational biology studies of the target indole-pyrimidines hybrids revealed that these compounds can serve as anti-inflammatory agents. This paper can potentially open new avenues for therapeutic strategies against inflammation-associated disorders. The synergy of synthetic innovation, pharmacological evaluation, and computational insights offers a holistic approach to advance our understanding of pyrimidines with an indole moiety as potential agents for mitigating inflammation.

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A post-sulfonated one-pot synthesized magnetic cellulose nanocomposite for Knoevenagel and Thorpe–Ziegler reactions

Abstract: Synthesis of a sulfonated magnetic cellulose nanocomposite to be applied in Knoevenagel and Thrope–Ziegler reactions. The catalyst promotes a sufficient and facile synthesis methodology for obtaining high-yield products.

Cited by 3 publications

References 84 publications

Application of Fe₃O₄@MCC Nanoparticles as a Heterogeneous Catalyst for Sustainable Multicomponent Synthesis of 2,3′‐Biindoles

Application of Fe₃O₄@MCC Nanoparticles as a Heterogeneous Catalyst for Sustainable Multicomponent Synthesis of 2,3′‐Biindoles

Cationic lignin as an efficient and sustainable homogenous catalyst for aqueous Knoevenagel condensation reactions

Anti-inflammatory Activity and Computational Biology Study of Indole/Pyrimidine Hybrids

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A post-sulfonated one-pot synthesized magnetic cellulose nanocomposite for Knoevenagel and Thorpe–Ziegler reactions

Abstract: Synthesis of a sulfonated magnetic cellulose nanocomposite to be applied in Knoevenagel and Thrope–Ziegler reactions. The catalyst promotes a sufficient and facile synthesis methodology for obtaining high-yield products.

Cited by 3 publications

References 84 publications

Application of Fe3O4@MCC Nanoparticles as a Heterogeneous Catalyst for Sustainable Multicomponent Synthesis of 2,3′‐Biindoles

Application of Fe3O4@MCC Nanoparticles as a Heterogeneous Catalyst for Sustainable Multicomponent Synthesis of 2,3′‐Biindoles

Cationic lignin as an efficient and sustainable homogenous catalyst for aqueous Knoevenagel condensation reactions

Anti-inflammatory Activity and Computational Biology Study of Indole/Pyrimidine Hybrids

Contact Info

Product

Resources

About

Application of Fe₃O₄@MCC Nanoparticles as a Heterogeneous Catalyst for Sustainable Multicomponent Synthesis of 2,3′‐Biindoles

Application of Fe₃O₄@MCC Nanoparticles as a Heterogeneous Catalyst for Sustainable Multicomponent Synthesis of 2,3′‐Biindoles