A post-pandemic perspective: Evolution of SARS-CoV-2 early detection

Zhu, Yidan; Jiang, Wenjun; Chen, Rui; Jouha, Jabrane; Wang, Qi; Wu, Li; Qin, Yuling

doi:10.1016/j.trac.2023.117458

Cited by 3 publications

(1 citation statement)

References 180 publications

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“…33,34 In this regard, the development of new diagnostic methodologies as alternatives to the PCR technique has led to the implementation of diagnostic tests centred on the use of new tools based on LAMP, RPA, or CRISPR/Cas9, among others. [35][36][37] Some of these methodologies are also highly portable to point-of-care (POC) systems, 38,39 which could prove effective in responding to critical situations, whether in remote locations or with limited equipment, or when facing reagent shortages associated with the PCR technique. 40 To address these limitations and expand the catalogue of available diagnostic methodologies, this work focused on implementing recent advances observed in the context of signal amplification strategies 24 with classical nucleic acid amplification technologies such as the RCA technique.…”

Section: Discussionmentioning

confidence: 99%

A FokI-driven signal amplification platform for the simultaneous detection of multiple viral RNA pathogens

Tejedor,

Roberti,

Mangas

et al. 2024

Sens. Diagn.

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Section: Discussionmentioning

confidence: 99%

A FokI-driven signal amplification platform for the simultaneous detection of multiple viral RNA pathogens

Tejedor,

Roberti,

Mangas

et al. 2024

Sens. Diagn.

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Recent Advances in DNA Nanotechnology‐Based Sensing Platforms for Rapid Virus Detection

Dong,

Guo,

Wang

et al. 2024

ChemBioChem

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Several major viral pandemics in history have significantly impacted the public health of human beings. The COVID‐19 pandemic has further underscored the critical need for early detection and screening of infected individuals. However, current detection techniques are confronted with deficiencies in sensitivity and accuracy, restricting the capability of detecting trace amounts of viruses in human bodies and in the environments.The advent of DNA nanotechnology has opened up a feasible solution for rapid and sensitive virus determination. By harnessing the designability and addressability of DNA nanostructures, a range of rapid virus sensing platforms have been proposed. This review overviewed the recent progress, application, and prospect of DNA nanotechnology‐based rapid virus detection platforms. Furthermore, the challenges and developmental prospects in this field were discussed.

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Advancing Diagnostics: Evaluating the Potential of Nanoparticle-Based Immunoassays as PCR Alternatives for Disease Confirmation

Kurdekar,

Kamisetti

2024

CAC

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In diagnostic technologies, searching for quick, accurate, and cost-efficient ways to confirm diseases has prompted the investigation of alternative methodologies to classic PCR-based tests. This article delves into the growing field of nanoparticle-based immunoassays, offering a comprehensive evaluation of their potential as viable alternatives to PCR for disease diagnostics. We discuss the basic principles of nanoparticle-based immunoassays, highlighting their distinctive capacity to combine the specialized binding characteristics of antibodies with the improved detection capacities of nanoparticles. The article compares the performance attributes of nanoparticle-based immunoassays compared to PCR, focusing on sensitivity, specificity, and detection speed. We further delve into a novel diagnostic technology, immuno-PCR, which integrates the strengths of immunoassays and PCR techniques. Healthcare systems and stakeholders must comprehend and implement novel diagnostic procedures emphasizing accuracy and sensitivity as the diagnostic landscape advances globally. This review contributes to the advancement of diagnostics by synthesizing current research and suggesting future directions for development. It highlights the transformative potential of current and emerging methods in shaping the future of disease diagnostics.

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A post-pandemic perspective: Evolution of SARS-CoV-2 early detection

Cited by 3 publications

References 180 publications

A FokI-driven signal amplification platform for the simultaneous detection of multiple viral RNA pathogens

A FokI-driven signal amplification platform for the simultaneous detection of multiple viral RNA pathogens

Recent Advances in DNA Nanotechnology‐Based Sensing Platforms for Rapid Virus Detection

Advancing Diagnostics: Evaluating the Potential of Nanoparticle-Based Immunoassays as PCR Alternatives for Disease Confirmation

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