A possible way to assess tidal exhaled nitric oxide in neonates and infants treated with nasal continuous positive airway pressure

Tidal breath eNO measurements in a cohort of unsedated hospitalized neonates—A method validation

“…As expected the subject-specific-prediction-variance was largest between infants, indicating that the method might be useful in differentiating at the individual level, or maybe between differences in diagnostic groups. 42 In protocol data, the predictions of individual eNO levels in the average infant had a precision of 0.05 SD, which differed substantially from 0.12 SD in complete data. Despite the young gestational age as well as postnatal age in our study-group at the time of measurement, the predictive ability of the method was high.…”

“…A clinical benefit of our approach on infants at risk of BPD could, therefore, be continuous evaluation of acute developing BPD by repetitive measurements during neonatal life, and thereby targeting the identification of possible responders of anti‐inflammatory treatment; even if it is still difficult to measure eNO in very premature infants. High eNO values in an infant with symptoms of bronchiolitis could indicate steroid responsiveness, though low eNO values are reported in acute RSV infections . Additionally, the information arising from the repetitive measuring of eNO during on‐going lung maturation and thereby angiogenesis and perfusion mentioned by Olsen et al could be useful in a research context.…”

Cohort profile: the vitamin A and D and nitric oxide (AD-ON) observational cohort on lung development and symptoms in premature and mature children in North Zealand, Denmark

“…Published data on this cohort include a validated and clinically applicable method to measure FeNO and V'NO (NO × flow) in preterm and term born neonates 45. With this method, we also showed that measuring tidal FeNO in respiratory unstable infants can be performed during a short (minutes) pause from CPAP treatment 53. The study design and cohort allowed us to construct longitudinal neonatal tidal FeNO and V'NO reference charts for preterm and term born neonates 54.…”

“… 45 With this method, we also showed that measuring tidal FeNO in respiratory unstable infants can be performed during a short (minutes) pause from CPAP treatment. 53 The study design and cohort allowed us to construct longitudinal neonatal tidal FeNO and V'NO reference charts for preterm and term born neonates. 54 Other key findings include the change of longitudinal FeNO values with postnatal age.…”