A possible role of stem cells in nasal polyposis

Klimek, Ludger; Koennecke, M.; Mullol, Joaquim; Hellings, Peter W.; Wang, D.Y.; Fokkens, Wytske J.; Gevaert, Philippe; Wollenberg, Barbara

doi:10.1111/all.13221

Cited by 17 publications

(20 citation statements)

References 93 publications

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“…The factors which play a critical role in the development of chronic inflammation and edema in NP still remain unclear. [15] Inf lammatory cytokines produced by T lymphocytes and macrophages induce inflammatory responses from the beginning to the end of the cascade. [16] Increased inflammatory cytokines in NP are common conspicuous factors.…”

Section: Discussionmentioning

confidence: 99%

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Association of TBX21 gene polymorphism with nasal polyposis

Kaya¹

2019

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Bu çalışmada nazal polipozis (NP) ve transkripsiyon gen ailesi (T-box) promotör bölgesi gen (TBX21) polimorfizmi arasında muhtemel ilişki araştırıldı. Hastalar ve Yöntemler: Bu retrospektif çalışmaya Temmuz 2018-Eylül 2018 tarihleri arasında daha önce NP nedeniyle ameliyat edilen veya tıbbi tedavi verilen 32 hasta (Grup 1) (23 erkek, 9 kadın; ort. yaş 42.5±15.0 yıl; dağılım, 18-83 yıl) ve multi-prick alerji test sonucu negatif olan ve herhangi bir nazal kavite patolojisi olmayan 50 sağlıklı kontrol (Grup 2) (21 erkek, 29 kadın; ort. yaş 32.7±9.9 yıl; dağılım, 18-83 yıl) dahil edildi. Tüm katılımcılarda TBX21 promotör bölgesinde-1993 T>C tek nükleotidli polimorfizm (SNP) araştırıldı. Bulgular: TBX21 heterozigot mutasyon taşıyıcı sayısı, Grup 1'de istatistiksel olarak anlamlı düzeyde daha yüksekti (p=0.001). Grup 1'de alerji öyküsü olmayanlara kıyasla alerji öyküsü olanlarda alel mutasyon pozitifliği anlamlı düzeyde daha yüksekti (p=0.028). Sonuç: TBX21 heterozigot mutasyon oranı NP'li hastalarda daha yüksek bulundu. TBX21'in-1993 T>C polimorfizmi, NP'nin etiyopatogenezinde rol oynayabilir.

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Section: Discussionmentioning

confidence: 99%

“…[16] Increased inflammatory cytokines in NP are common conspicuous factors. [15] In Western populations, NP is often characterized by type 2 inf lammation with elevated levels of Th2-specific cytokines. In addition, in Asian populations, NP may be characterized by Th1/Th17 mixed inflammatory pattern.…”

Section: Discussionmentioning

confidence: 99%

Association of TBX21 gene polymorphism with nasal polyposis

Kaya¹

2019

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“…Stem/progenitor cells have a central role in tissue homeostasis, repair and regeneration of mucous membrane including the nasal mucosa [ 27 ]. The cellular pathogenesis of nasal polyps is related to a homeostatic imbalance between the reduction in proliferation of nasal epithelial stem/progenitor cells [ 28 ], and the presence and differentiation of mesenchymal stem/progenitor cells (MSCs) [ 29 ].…”

Section: Intra-cellular Signaling Transduction Mechanisms Underlyimentioning

confidence: 99%

“…Nasal polyp tissue has been explored as a novel source of MSCs maintaining the stemness features and differentiation potential following multiple rounds of passaging [ 29 ], these Nasal polyp-derived MSCs (PO-MSCs) show a spindle-shaped morphology and typical features of MSCs [ 61 , 62 , 63 ]. The PO-MSCs phenotype is similar to that of MSCs derived from bone marrow or adipose tissue and is characterized by a positive expression for classical mesenchymal surface antigens, CD105, CD44, CD54, CD90, and CD73 [ 29 , 50 , 62 ], and a negative expression for hematopoietic surface markers (CD34, CD45, and HLA-DR). The PO-MSCs show high clonogenicity ability and can be passaged up to 15 times, maintaining their self-renewal ability [ 62 ].…”

Section: Gene Expression Studies On Nasal Polyps and Their Derivedmentioning

confidence: 99%

Nasal Polyposis: Insights in Epithelial-Mesenchymal Transition and Differentiation of Polyp Mesenchymal Stem Cells

Chiarella

Lombardo

Lobello

et al. 2020

IJMS

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Chronic rhinosinusitis is a common inflammatory disease of paranasal sinuses, which causes rhinorrhea, nasal congestion, and hyposmia. The genetic predisposition or the exposure to irritants can sustain the inflammatory response and the development of nasal polyposis. Nasal polyps are benign and teardrop-shaped growths that project in the nasal cavities, and originate from the ethmoid sinuses. This inflammatory process is associated with high expression of IL-4, IL-5 and IL-13 and IgE. Antibodies targeting these cytokines or receptors represent a therapeutic strategy in the treatment of nasal polyposis in combination with corticosteroids. The molecular pathogenesis of nasal polyps in chronic rhinosinusitis (CRS) patients is associated with remodeling transition, a process in which epithelial cells lose their typical phenotype, acquiring a mesenchymal-like aspect. TGFβ/SMAD, ERK, and Wnt/β-catenin pathways are altered during the nasal tissue remodeling. miRNA and inhibitor molecules targeting these signaling pathways are able to interfere with the process; which could lead to alternative therapies. Nasal polyps are an alternative source of mesenchymal stem cells, which can be isolated from surgical biopsies. A molecular understanding of the biology of PO-MSCs will contribute to the delineating inflammatory process underlying the development of nasal polyps.

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“…The sinonasal epithelium is the first line of defence in the nose, forming a physical barrier against entry of nocuous matter, producing the mucus layer and providing mucociliary clearance . It is composed of four different cell types: ciliated columnar cells and nonciliated columnar cells, goblet cells and basal cells, of which the latter have considerable importance due to their regenerative properties . Impairment in the sinonasal epithelial barrier results in increased permeability and entry of potentially injurious entities, with a downstream exaggerated inflammatory response (Figure ).…”

Section: Precision Medicine In Crsmentioning

confidence: 99%

Novel findings in immunopathophysiology of chronic rhinosinusitis and their role in a model of precision medicine

Ong

Wang

2019

Allergy

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Our understanding of the pathophysiology of chronic rhinosinusitis (CRS) is continuously evolving. The traditional description of CRS in terms of two phenotypes based on the presence or absence of nasal polyps belies the underlying intricate immunopathophysiological processes responsible for this condition. CRS is being increasingly recognized as a disease spectrum encompassing a range of inflammatory states in the sinonasal cavity, with non-type 2 inflammatory disease on one end, type 2 inflammatory, eosinophil-heavy disease on the other and an overlap of both in different proportions in between. Abundance in research on the immune mechanisms of CRS has revealed various new endotypes that hold promise as biomarkers for the development of targeted therapies in severe, uncontrolled CRS. The introduction of precision medicine to manage this chronic, complex condition is a step forward in providing individualized care for all patients with CRS. In this review, the latest research on the pathophysiology of CRS with a focus on potential novel biomarkers and treatment options over the last 2 years are summarized and integrated into a suggested model of precision medicine in CRS. K E Y W O R D S biomarkers, chronic rhinosinusitis, endotypes, immunopathophysiology, precision medicine

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A possible role of stem cells in nasal polyposis

Abstract: Since its discovery, the understanding of stem/progenitor cells raised dramatically in the last decade. Their regenerative potential is important to develop new therapeu-

Cited by 17 publications

References 93 publications

Association of TBX21 gene polymorphism with nasal polyposis

Association of TBX21 gene polymorphism with nasal polyposis

Nasal Polyposis: Insights in Epithelial-Mesenchymal Transition and Differentiation of Polyp Mesenchymal Stem Cells

Novel findings in immunopathophysiology of chronic rhinosinusitis and their role in a model of precision medicine

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