2017
DOI: 10.1096/fasebj.31.1_supplement.lb776
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A Possible Role of Skeletal Muscle‐Derived Adiponectin in the Regulation of Skeletal Muscle Mass

Abstract: Aging‐associated severe skeletal muscle atrophy, so‐called sarcopenia, is considered as a risk factor for falls in older adults. Recent cohort studies shows high circulating adiponectin levels predict decreased muscle strength among older adults. Adiponectin, one of adipokines, is exclusively synthesized in adipocytes, is secreted into circulation, binds to adiponectin receptors (AdRs), especially AdR1, and exhibits insulin‐sensitizing effects to stimulate the utilization of glucose and lipids in skeletal musc… Show more

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