A possible role of prolactin in adjuvant arthritis

Berczi, István; Nagy, Éva

doi:10.1002/art.1780250517

Cited by 49 publications

(16 citation statements)

References 20 publications

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“…Immune responses now known to involve prolactin action include contact sensitivity skin reaction to dinitrochlorobenzene (22,23), antibody formation to sheep erythrocytes and to bacterial LPS (22,23), adjuvant arthritis (23)(24)(25), experimental allergic encephalitis (23), graft-versus-host reaction (26,27), allograft rejection process (11,12,26), lymphocyte mitogenesis (11,12,27,28), natural killer cell activity (29), cyclosporine immunosuppressive action (5,6,27,30), and macrophage activation (31,32). The earliest endocrine (33).…”

Section: Discussionmentioning

confidence: 99%

Neonatal administration of prolactin antiserum alters the developmental pattern of T- and B-lymphocytes in the thymus and spleen of BALB/c female mice.

Russell

Mills

Talamantes

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

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We have evaluated the effect of neonatal administration of mouse prolactin (PRL) antiserum on the developmental expression of T. and B-lymphocytes in the thymus and spleen of female BALB/c mice. Newborn female mice were injected subcutaneously with a 50-,4l aliquot of PRL antiserum or normal rabbit serum on days 1, 2, and 3. On neonatal day 5, the PRL antiserum-treated group had a significantly (P < 0.05) increased population of cells in the thymus and the spleen that were positive for Thy-1.2 and for L3T4. Increases in Thy-1.2-and L3T4-positive cells in the thymus were detectable also on days 8 and 14 in mice that received the PRL antiserum and in mice injected with bromocriptine, a dopamine agonist t4at inhibits PRL release from the anterior pituitary. On neonatal days 21, 28, and 32, there were no significant differences in the percentage of cells positive for Thy-1.2, Ly-2 (formerly Lyt-2), or L3T4 antigens in the thymus. However, there were significant increases in the percentage of Thy-1.2-and L3T4-positive spleen cells in the bromocriptine-treated group at all.times monitored and in the PRL antiserum-treated group except on day 14. In addition, the percentage of splenocytes that were positive for IgG was significantly increased in the PRL antiserum-treatment group on days 8-28, although not on neonatal day 32. Of tissues known to contain PRL receptors, neonatal administration of PRL antiserum or bromocriptine resulted in a significant alteration in the wet weight of spleen and liver, with no significant effect in thymus, heart, and kidney. Pituitary implants also resulted in a significant increase in both concanavalin A-and lipopolysaccharide-stimulated thymidine incorporation into murine splenic lymphocytes prepared from 45-day-old female mice. These data extend the role of PRL as an immunomodulator of adult lymphocyte function to a role in the developmental expression of T-and B-lymphocyte populations in the thymus and spleen of mice.A host of diverse biological effects has been ascribed to prolactin (PRL) (1-4). Sigma; 60 ug in 25 ,uI of 30% (vol/vol) propylene glycol/10% (vol/vol) ethanol/60% (vol/vol)

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Section: Discussionmentioning

confidence: 99%

Neonatal administration of prolactin antiserum alters the developmental pattern of T- and B-lymphocytes in the thymus and spleen of BALB/c female mice.

Russell

Mills

Talamantes

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

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“…In lymphocytes, PRL is known to increase hormonal and cellular immunity (399,402), to reverse anemia, leukopenia, and thrombocytopenia induced by hypophysectomy (407), to increase antibody formation, including IgG and IgM antibodies (404 -406), and to induce cellular proliferation (203, 408 -410), although this last function is somewhat controversial, as not all investigators are able to reproduce PRLinduced proliferation of lymphocytes. Recently, in fact, it has been suggested that the proliferative action of PRL of recombinant origin and even natural preparations may be due to contamination with endotoxins, which are responsible for the immunostimulatory actions that have been observed (480).…”

Section: F Immunoregulation and Protectionmentioning

confidence: 99%

Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice

1998

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“…Hypophysectomized rats fail to mount an immune response (7,8). Treatment of those animals with prolactin or GH, but not with corticotropin or other pituitary hormones, restored their immunological status (9).…”

mentioning

confidence: 98%

Prolactin as a modulator of lymphocyte responsiveness provides a possible mechanism of action for cyclosporine.

Hiestand¹,

Mekler²,

Nordmann³

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

210

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Lymphocyte responsiveness in rats was found to depend on serum prolactin levels. Blocking pituitary prolactin release with bromocriptine severely reduces lymphocyte reactivity in vitro (mixed lymphocyte reaction) as well as in vivo (graft-versus-host reaction). In addition, evidence for a prolactin/growth hormone-related mRNA species produced in mitogen-and antigen-stimulated lymphocytes has been obtained. Prolactin was shown to compete in a dose-dependent fashion with the immunosuppressant cyclosporine (cyclosporin A) for a common binding site on the surface of T lymphocytes. Further, stimulation of prolactin secretion reversed the immunosuppression induced by cyclosporine. We conclude that prolactin is involved in the maintenance of T-cell immunocompetence and that the immunosuppressive effects of cyclosporine may be mediated by the displacement of prolactin from binding sites on lymphocytes.

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A possible role of prolactin in adjuvant arthritis

Cited by 49 publications

References 20 publications

Neonatal administration of prolactin antiserum alters the developmental pattern of T- and B-lymphocytes in the thymus and spleen of BALB/c female mice.

Neonatal administration of prolactin antiserum alters the developmental pattern of T- and B-lymphocytes in the thymus and spleen of BALB/c female mice.

Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice

Prolactin as a modulator of lymphocyte responsiveness provides a possible mechanism of action for cyclosporine.

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