A possible role of BDNF in prostate cancer detection

Bronzetti, Elena; Artico, Marco; Forte, Frank; Pagliarella, G; Felici, Lm; D'Ambrosio, A; Vespasiani, Giuseppe; Bronzetti, B

doi:10.3892/or.19.4.969

Cited by 26 publications

(25 citation statements)

References 11 publications

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“…The data described above confirmed our previous experimental findings (8)(9)(10)(11), hence improving our knowledge on the role of the neurotrophins in the regulation of the meningeal microenvironment and their direct participation in the neoplastic transformation and cellular survival, both essential aspects of the malignant development.…”

Section: Discussionsupporting

confidence: 87%

“…The neoplastic cells in the whorls showed a remarkable immunoreactivity for BDNF and TrkB (Fig. 2B and D), thus confirming our previous results in other neoplastic tissues, such as lung and prostate (11,12), in which we demonstrated a significant role of BDNF in the increased proliferation rate of neoplastic lesions.…”

Section: Immunohistochemistrysupporting

confidence: 79%

“…A definite role of NTs in the dural and leptomeningeal compartments is not well ascertained but a previous study on the expression of mRNAs for NTs revealed high levels of NT3 and NGF in the normal rat dura mater (7). Our observations on the localization and possible roles in different non-neuronal tissues such as lymphoid, lung and prostate (8)(9)(10)(11) encouraged us to persist in our experimental investigations in order to find a possible involvement of NTs in dura mater, both in physiological and pathological conditions (meningiomas).…”

Section: Introductionmentioning

confidence: 80%

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Immunohistochemical profile of neurotrophins in human cranial dura mater and meningiomas

et al. 2009

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Abstract. The immunohistochemical profile of neurotrophins and their receptors in the human cranial dura mater was studied by examining certain dural zones in specimens harvested from different regions (frontal, temporal, parietal and occipital). Dural specimens were obtained during neurosurgical operations performed in ten patients for surgical treatment of intracranial lesions (meningiomas, traumas, gliomas, vascular malformations). The dural fragments were taken from the area of the craniotomy at least 8 cm from the lesion as well as from the area in which the meningioma had its dural attachment. Immunohistochemical characterization and distribution of neurotrophins, with their receptors, were analyzed. The concrete role played by these neurotrophic factors in general regulation, vascular permeability, algic responsivity and release of locally active substances in the human dura mater is still controversial. Our study revealed a general structural alteration of dural tissue due to the invasivity of meningiomatous lesions, together with an improved expression of brain derived neurotrophic factor (BDNF) in highly proliferating neoplastic cells and an evident production of nerve growth factor (NGF) in inflammatory cells, suggesting that BDNF has a role in supporting the proliferation rate of neoplastic cells, while NGF is involved in the activation of a chronic inflammatory response in neoplastic areas. IntroductionMeningiomas are the most common benign intracranial tumors, but some meningiomas show malignancy with invasion into the surrounding structures, as well as a high recurrence rate and extracranial metastases (1). Meningiomas arise from arachnoidal cells, most of which lie in close proximity to the venous sinuses: in fact, this is the most common site for meningioma formation. They are most frequently attached to the dura mater over the superior parasagittal surface of the frontal and parietal lobes, along the sphenoid ridge, in the olfactory grooves, the Sylvian region, superior cerebellum along the falx cerebri, cerebellopontine angle and spinal cord. The tumor is usually well-circumscribed, with the base lying on the dura mater.Histologically, the cells are relatively uniform, with a tendency to form highly-circumscribed whorls and to generally disrupt the distribution and the structure of collagen fibers (main component of dural tissue) and to originate 'psammoma bodies' (laminated concretions) which can calcify and are often strongly vascularized.The remarkable proliferation rate and vascularisation which determine a rapid replacement of normal dural tissue by the neoplastic cells, is regulated by several different growth factors, such as NGF related to an increased activation of the inflammatory cells at the beginning of the neoplastic invasion and BDNF, involved in the increased activation of the tumoral cells.Neurotrophins (NTs), also known as neurotrophic factors, constitute a family of dimeric proteins working as polypeptidic growth factors and acting like extracellular ligands. NTs, including ...

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Section: Discussionsupporting

confidence: 87%

Section: Immunohistochemistrysupporting

confidence: 79%

Section: Introductionmentioning

confidence: 80%

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Immunohistochemical profile of neurotrophins in human cranial dura mater and meningiomas

et al. 2009

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“…Interestingly, brain-derived neurotrophic factor (BDNF), has been linked to prostate cancer [25]. We easily identify BDNF in the Singh dataset (rank=3), but not in the Chandran data (rank=420).…”

Section: Interpretation Of Selected Genesmentioning

confidence: 95%

Combining multiple microarray studies using bootstrap meta-analysis

Barrett

Phan

Wang

2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Microarray technology has enabled us to simultaneously measure the expression of thousands of genes. Using this high-throughput technology, we can examine subtle genetic changes between biological samples and build predictive models for clinical applications. Although microarrays have dramatically increased the rate of data collection, sample size is still a major issue when selecting features. Previous methods show that combining multiple microarray datasets improves feature selection using simple methods such as fold change. We propose a wrapper-based gene selection technique that combines bootstrap estimated classification errors for individual genes across multiple datasets and reduces the contribution of datasets with high variance. We use the bootstrap because it is an unbiased estimator of classification error that is also effective for small sample data. Coupled with data combination across multiple datasets, we show that our metaanalytic approach improves the biological relevance of gene selection using prostate and renal cancer microarray data.

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“…In addition to the CNS and PNS, BDNF has been expressed in range of tissues and cells such as kidney, prostate, and retina (BRONZETTI, 2008;MANDEL, 2009 …”

Section: Bdnfmentioning

confidence: 99%

Análise da expressão de neurotrofinas durante a regeneração de nervo periférico de rato por enxerto venoso

Ahmed¹

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A possible role of BDNF in prostate cancer detection

Cited by 26 publications

References 11 publications

Immunohistochemical profile of neurotrophins in human cranial dura mater and meningiomas

Immunohistochemical profile of neurotrophins in human cranial dura mater and meningiomas

Combining multiple microarray studies using bootstrap meta-analysis

Análise da expressão de neurotrofinas durante a regeneração de nervo periférico de rato por enxerto venoso

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