A possible role for prostaglandins in the expression of morphine dependence in guinea‐pig isolated ileum

Johnson, Megan A.; Hill, R.G.; Hughes, Jonathan

doi:10.1111/j.1476-5381.1988.tb11482.x

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…Finally, earlier studies had shown that the antagonist‐induced response in tissues exposed to opioid agonists and CCK‐8 was inhibited by clonidine, nifedipine ( Valeri et al ., 1990b ) and non‐steroidal anti‐inflammatory drugs ( Valeri et al ., 1993 ). It therefore had the same pharmacological characteristics as the withdrawal response obtained in tissues exposed to opioid agonists alone ( Chahl, 1985 ; Borrios & Baeyens, 1988 ; Johnson et al ., 1988 ; Valeri et al ., 1990a ).…”

Section: Discussionmentioning

confidence: 91%

Interactions between cholecystokinin and opioids in the isolated guinea‐pig ileum

Romanelli

Amico

Mattioli

et al. 1999

British J Pharmacology

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1 Although cholecystokinin octapeptide sulphate (CCK-8) activates the opioid system of isolated guinea-pig ileum (GPI) whether it activates the m-or k-system, or both, remains unclear. Neither is it known whether CCK-8 in¯uences the withdrawal responses in GPI preparations brie¯y exposed to opioid agonists. This study was designed to clarify whether CCK-8 activates m-or k-opioid systems or both; and to investigate its eect on the withdrawal contractures in GPI exposed to m-or kagonists and on the development of tolerance to the withdrawal response. 2 In GPI exposed to CCK-8, the selective k-antagonist nor-binaltorphimine elicited contractile responses that were concentration-related to CCK-8 whereas the selective m-antagonist cyprodime did not. 3 In GPI preparations brie¯y exposed to the selective m-agonist, dermorphin, or the selective kagonist, U-50, 488H, and then challenged with naloxone, CCK-8 strongly enhanced the withdrawal contractures. 4 During repeated opioid agonist/CCK-8/opioid antagonist tests tolerance to opioid-induced withdrawal responses did not develop. 5 These results show that CCK-8 preferentially activates the GPI k-opioid system and antagonizes the mechanism(s) that control the expression of acute dependence in the GPI.

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Section: Discussionmentioning

confidence: 91%

Interactions between cholecystokinin and opioids in the isolated guinea‐pig ileum

Romanelli

Amico

Mattioli

et al. 1999

British J Pharmacology

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“…Quercetin inhibits the formation of the inflammatory mediators such as prostaglandins through its inhibitory action on cyclooxygenase activity [Melzig et al, 2001;Chen et al, 2001]. Chronic treatment with morphine increased prostaglandin activity [Scoto et al, 1979], and prostaglandins are reported to have a role in the development of morphine tolerance and dependence [Johnson et al, 1988], and cyclooxygenase inhibitors are reported to be effective in reversal of morphine tolerance and dependence [Powell et al, 1999] . The reversal of morphine tolerance and dependence by quercetin might be due to its inhibitory action on cyclooxygenase enzyme and prostaglandin synthesis.…”

Section: Discussionmentioning

confidence: 98%

Quercetin, a bioflavonoid, reverses development of tolerance and dependence to morphine

Singh

Naidu

Kulkarni

2002

Drug Development Research

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Quercetin, a bioflavonoid (25 and 50 mg/kg), when chronically administered for 9 days, failed to produce any significant change in tail flick latency as compared to control mice. However, repeated administration of quercetin (25 and 50 mg/kg) for 9 days attenuated the development of tolerance to the analgesic effect of morphine (10 mg/kg). Quercetin (25 and 50 mg/kg) also suppressed naloxone (2 mg/kg)-precipitated withdrawal jumps on day 10 in morphine-tolerant mice. Pretreatment of mice with quercetin (10-50, ip) significantly reversed the morphine (5 mg/kg)-induced delay in gastric transit, whereas a higher dose of quercetin (100 mg/kg) did not have any significant effect on morphine-induced delay in gastric transit. Quercetin per se had no effect on gastric transit. In conclusion, the results of the present study suggest potential use of quercetin in alleviating the adverse effects of opioid treatment. Drug Dev.

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Dose-dependent and stereoselective antagonism by diltiazem of naloxone-precipitated morphine abstinence after acute morphine-dependence and

1988

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A possible role for prostaglandins in the expression of morphine dependence in guinea‐pig isolated ileum

Cited by 8 publications

References 9 publications

Interactions between cholecystokinin and opioids in the isolated guinea‐pig ileum

Interactions between cholecystokinin and opioids in the isolated guinea‐pig ileum

Quercetin, a bioflavonoid, reverses development of tolerance and dependence to morphine

Dose-dependent and stereoselective antagonism by diltiazem of naloxone-precipitated morphine abstinence after acute morphine-dependence and

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