A possible relationship between catecholamines and acute toxicity of desipramine

Lal, Harbans; Brown, Roger M.

doi:10.1007/bf00401414

Cited by 2 publications

(1 citation statement)

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“…Furthermore, a close link exists between changes in the pituitary-adrenal axis, activation of the central NE and DA system, stress responses and aggression [21]. Aggressive behaviors have been induced by administering precursors of NE [22]. However the mechanism by which NE enhances aggression are not fully understood, it is thought that it inhibits neurons in the brain stem which suppress aggression [23].…”

Section: Discussionmentioning

confidence: 99%

High aggression in rats is associated with elevated stress, anxiety-like behavior, and altered catecholamine content in the brain

Patki

Atrooz

Alkadhi

et al. 2015

Neuroscience Letters

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The social defeat paradigm involves aggressive encounters between Long-Evans (LE) (resident) and Sprague-Dawley (SD) (intruder) rats. Successful application of chronic social defeat stress in SD rats is dependent upon selection of highly aggressive LE rats. Half of the LE rats screened for aggression did not meet the criterion for aggression (LE rats performing a defeat, characterized by the intruder surrendering or acquiring a supine position for at least 3 sec). The observation of the differences in the level of aggression between age and weight matched LE rats was quite compelling which led us to the present study. Herein, we measured behavioral differences between aggressor and non-aggressor LE rats. We analyzed their anxiety-like behavior using open-field and elevated plus maze tests. We also measured aggression/violence-like behavior using two tests. In one, time taken to defeat the intruder SD rat was recorded. In the second test, time taken to attack a novel object was compared between the two groups. We observed a significant increase in anxiety-like behavior in aggressor rats when compared to the non-aggressive group. Furthermore, time taken to defeat the intruder rat and to attack a novel object was significantly lower in aggressive LE rats. Biochemical data suggests that heightened anxiety-like behavior and aggression is associated with increased plasma levels of corticosterones and elevated oxidative stress. Significant alterations in dopamine (DA), norepinephrine (NE) and epinephrine (EPI) were observed within the hippocampus, amygdala and the prefrontal cortex, suggesting potential involvement of dopaminergic and noradrenergic systems in regulation of aggressive behaviors.

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Section: Discussionmentioning

confidence: 99%