A possible link between increased metabolic activity of fat tissue and aortic wall inflammation in subjects with COPD. A retrospective 18F-FDG-PET/CT pilot study

Vanfleteren, Lowie E.G.W.; Meerendonk, Aniek M.G. van; Franssen, Frits M.E.; Wouters, Emiel F.M.; Mottaghy, Felix M.; Kroonenburgh, Marinus J. van; Bucerius, Jan

doi:10.1016/j.rmed.2014.04.001

Cited by 23 publications

(19 citation statements)

References 39 publications

(39 reference statements)

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“…Hepatic steatosis develops in the context of increased triglyceride flux into the liver from visceral adipose tissue [41]. Furthermore, fat inflammation, which has been demonstrated in COPD [42], drives the development of NAFLD. Excessive and inflamed visceral fat is associated with circulating cytokines including leptin and TNF-α [43,44].…”

Section: Discussionmentioning

confidence: 99%

Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease

et al. 2017

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Nonalcoholic fatty liver disease (NAFLD) is independently linked to cardiometabolic morbidity and mortality. Low-grade inflammation, oxidative stress and ectopic fat, common features of chronic obstructive pulmonary disease (COPD), might contribute to the development of NAFLD.We aimed to investigate the prevalence of NAFLD and to evaluate the relationship between various types of liver damage and COPD severity, comorbidities and circulating inflammatory cytokines. Validated noninvasive tests (FibroMax: SteatoTest, NashTest and FibroTest) were used to assess steatosis, nonalcoholic steatohepatitis (NASH) and liver fibrosis. Patients underwent an objective assessment of COPD comorbidities, including sleep studies. Biological parameters included a complete lipid profile and inflammatory markers.In COPD patients the prevalence of steatosis, NASH and fibrosis were 41.4%, 36.9% and 61.3%, respectively. In multivariate analysis, SteatoTest and FibroTest were significantly associated with sex, body mass index (BMI), untreated sleep apnoea and insulin resistance, and, in addition, COPD Global Initiative for Chronic Obstructive Lung Disease stage for SteatoTest. Patients with steatosis had higher tumour necrosis factor-α levels and those with NASH or a combination of liver damage types had raised leptin levels after adjustment for age, sex and BMI.We concluded that NAFLD is highly prevalent in COPD and might contribute to cardiometabolic comorbidities.

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Section: Discussionmentioning

confidence: 99%

Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease

et al. 2017

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“…We calculated that 12 patients and 24 controls would provide a power of at least 80% to detect a 20% clinically relevant difference in TBR between groups, assuming a ratio of 2, an SD of 20% and expected mean TBR values of 1 at a two‐sided α level of 0·05 …”

Section: Methodsmentioning

confidence: 99%

Increased global arterial and subcutaneous adipose tissue inflammation in patients with moderate-to-severe psoriasis

et al. 2016

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“…Similarly, Vanfleteren et al reported in a retrospective study that patients with COPD had significantly increased levels of FDG uptake in abdominal VAT based on PET/CT compared to non-COPD controls, whereas abdominal SAT did not significantly differ in the level of FDG uptake. In addition, FDG uptake in abdominal VAT was significantly correlated with FDG uptake in the abdominal aorta, independent of patient age and BMI [26]. However, Christen et al reported in a retrospective study that VAT exhibited higher FDG uptake compared to SAT independent of age, sex, BMI, comorbidities, smoking history, and medications [27].…”

Section: Discussionmentioning

confidence: 99%

A Study of the Feasibility of FDG-PET/CT to Systematically Detect and Quantify Differential Metabolic Effects of Chronic Tobacco Use in Organs of the Whole Body—A Prospective Pilot Study

et al. 2017

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Objective The aim of this study was to assess the feasibility of 18F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) to systematically detect and quantify differential effects of chronic tobacco use in organs of the whole body. Methods 20 healthy male subjects (10 non-smokers and 10 chronic heavy smokers) were enrolled. Subjects underwent whole-body FDG-PET/CT, diagnostic unenhanced chest CT, mini-mental state examination (MMSE), urine testing for oxidative stress and serum testing. Organs of interest (thyroid, skin, skeletal muscle, aorta, heart, lung, adipose tissue, liver, spleen, brain, lumbar spinal bone marrow, and testis) were analyzed from FDG-PET/CT images to determine their metabolic activities using standardized uptake value (SUV) or metabolic volumetric product (MVP). Measurements were compared between subject groups using 2-sample t-tests or Wilcoxon rank-sum tests as determined by tests for normality. Correlational analyses were also performed. Results FDG-PET/CT revealed significantly decreased metabolic activity of lumbar spinal bone marrow (MVPmean 29.8±9.7 cc vs. 40.8±11.6 cc, p=0.03) and liver (SUVmean 1.8±0.2 vs. 2.0±0.2, p=0.049), and increased metabolic activity of visceral adipose tissue (VAT) (SUVmean 0.35±0.10 vs. 0.26±0.06, p=0.02) in chronic smokers compared to non-smokers. Normalized VAT volume was also significantly decreased (p=0.04) in chronic smokers. There were no statistically significant differences in the metabolic activity of other assessed organs. Conclusions Subclinical organ effects of chronic tobacco use are detectable and quantifiable on FDG-PET/CT. FDG-PET/CT may therefore play a major role in the study of systemic toxic effects of tobacco use in organs of the whole body for clinical or research purposes.

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A possible link between increased metabolic activity of fat tissue and aortic wall inflammation in subjects with COPD. A retrospective 18F-FDG-PET/CT pilot study

Cited by 23 publications

References 39 publications

Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease

Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease

Increased global arterial and subcutaneous adipose tissue inflammation in patients with moderate-to-severe psoriasis

A Study of the Feasibility of FDG-PET/CT to Systematically Detect and Quantify Differential Metabolic Effects of Chronic Tobacco Use in Organs of the Whole Body—A Prospective Pilot Study

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