A possible in vivo skin model for tumour promoter assays

Armuth, Vlasta; Berenblum, I.

doi:10.1016/0304-3835(82)90136-7

Cited by 11 publications

(2 citation statements)

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“…Anthranil (2,1-benzisoxazole), whose infrared and Raman spectra have been reported, 12 and its derivatives are well known due to their extensive applications in pharmacology and analytical chemistry. [13][14][15][16][17] While the topical anthranil treatment was suggested for possible use in the bioassay of tumor promoters 13 and some anthranil derivatives have shown cytotoxic and mutagenic activity, 14 other anthranil derivatives proved to possess a protective antiulcer effect and sedative activity. 15,16 It was also shown 18 that anthranil is the key intermediate in the decomposition process of nitroaromatic explosives.…”

Section: Introductionmentioning

confidence: 99%

Surface-Enhanced Raman Scattering and Density Functional Theoretical Study of Anthranil Adsorbed on Colloidal Silver Particles

Baia

Kiefer

et al. 2004

J. Phys. Chem. B

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Surface-enhanced Raman spectrum of anthranil (2,1-benzisoxazole) in activated silver colloid was recorded and compared with the conventional Raman spectrum. The experimentally observed Raman bands along with their corresponding infrared bands were assigned based on the results of density functional theory (DFT) calculations. The significant changes evidenced between the SER and normal Raman spectra combined with the theoretical data obtained for Ag−anthranil model systems demonstrated that this molecule is adsorbed on the colloidal silver particles through the lone pair electrons of the nitrogen atom. The contribution of the chemical mechanism to the SERS enhancement was proved by the behavior of the electronic absorption spectrum of the mixture of activated silver colloid and anthranil solution. The orientation of the adsorbed species with respect to the metal surface was also predicted.

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Section: Introductionmentioning

confidence: 99%

Surface-Enhanced Raman Scattering and Density Functional Theoretical Study of Anthranil Adsorbed on Colloidal Silver Particles

Baia

Kiefer

et al. 2004

J. Phys. Chem. B

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“…A large number of antitumor drugs (such as Imatinib, [2] Gifitinib, [3] Dasatinib, [4] etc.) and antimicrobial compounds (such as trimethoprim (TMP), [5] trimetrexate, [6] piritrexim (PTX), [7] etc.) contain a pyrimidine motif as well.…”

mentioning

confidence: 99%

A Site‐Selective C−N Bond Formation of 2,4‐Dichloro‐5H‐pyrano[2,3‐d]pyrimidines and Amide

Qin

Cao

et al. 2021

ChemistrySelect

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A serious of C4‐position aniline functionalized 5H‐pyrano[2,3‐d]pyrimidine derivatives were synthesized from the corresponding chlorinated pyrimidines and acetanilides. This process was approached by treating the acetanilide with NaH instead of aniline, where a dissociation of the acyl group in situ happened during the reaction. The strategy worked out the non‐reactive route resulted from the low reactivity of aniline. This C−N bond formation features mild reaction conditions, simple execution, and broad substrate scope.

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2,1‐Benzisoxazoles

Eswaran

1999

Chemistry of Heterocyclic Compounds: A Series of Monographs

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A possible in vivo skin model for tumour promoter assays

Cited by 11 publications

References 2 publications

Surface-Enhanced Raman Scattering and Density Functional Theoretical Study of Anthranil Adsorbed on Colloidal Silver Particles

Surface-Enhanced Raman Scattering and Density Functional Theoretical Study of Anthranil Adsorbed on Colloidal Silver Particles

A Site‐Selective C−N Bond Formation of 2,4‐Dichloro‐5H‐pyrano[2,3‐d]pyrimidines and Amide

2,1‐Benzisoxazoles

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