A possible function of the chilamydospores of Candida albicans

Bakerspigel, A.; Burke, Shanna L.

doi:10.1007/bf02055984

Cited by 13 publications

(8 citation statements)

References 9 publications

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“…However, the results of these studies were inconsistent. In contrast, Bakerspigel & Burke (1974) were unable to induce germination of chlamydospores, leading them to propose that chlamydospores have a role as storage cells. However, other authors (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Purification and germination ofCandida albicansandCandida dubliniensischlamydospores cultured in liquid media

Citiulo

Moran

Coleman

et al. 2009

FEMS Yeast Research

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Candida albicans and Candida dubliniensis are the only Candida sp. that have been observed to produce chlamydospores. The function of these large, thick-walled cells is currently unknown. In this report, we describe the production and purification of chlamydospores from these species in defined liquid media. Staining with the fluorescent dye FUN-1 indicated that chlamydospores are metabolically active cells, but that metabolic activity is undetectable in chlamydospores that are >30 days old. However, 5-15-day-old chlamydospores could be induced to produce daughter chlamydospores, blastospores, pseudohyphae and true hyphae depending on the incubation conditions used. Chlamydospores that were preinduced to germinate were also observed to escape from murine macrophages following phagocytosis, suggesting that these structures may be viable in vivo. Mycelium-attached and purified chlamydospores rapidly lost their viability in water and when subjected to dry stress, suggesting that they are unlikely to act as long-term storage structures. Instead, our data suggest that chlamydospores represent an alternative specialized form of growth by C. albicans and C. dubliniensis.

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Section: Introductionmentioning

confidence: 99%

“…Martin et al, 2005) do not consider a chlamydospore a structure distinct from a suspensor cell at this stage. In contrast, Bakerspigel & Burke (1974) were unable to induce germination of chlamydospores, leading them to propose that chlamydospores have a role as storage cells.…”

Section: Introductionmentioning

confidence: 99%

Purification and germination ofCandida albicansandCandida dubliniensischlamydospores cultured in liquid media

Citiulo

Moran

Coleman

et al. 2009

FEMS Yeast Research

View full text Add to dashboard Cite

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“…Only in some rare cases, chlamydospore formation in liquid media was documented. 67,69,71 The fact that other investigators 50,65 failed to induce chlamydospores in C. albicans under the conditions proposed by Bakerspigel and Burke, might also be due to strain-specific differences. In view of the recent description of C. dubliniensis, it cannot be excluded that some of the C. albicans strains used in experiments in the past might have been C. dubliniensis.…”

Section: Isolationmentioning

confidence: 94%

“…Torosantucci and Cassone demonstrated chlamydospore formation in an agerminative variant of C. albicans and suggested that chlamydospore development is not necessarily associated with hyphal morphogenesis 90 . Another interesting observation was made by Bakerspigel and Burke [67], who observed chlamydospores which arose from C. albicans blastospores in a liquid medium composed of 1% sodium taurocholate in distilled water. We also found that under certain culture conditions C. dubliniensis can form chlamydospores in the absence of filaments (P. Staib & J. Morschhäuser, unpublished data).…”

Section: Does Candida Albicans Chlamydospore Formation Depend On Filamentioning

confidence: 97%

Chlamydospore formation in Candida albicans and Candida dubliniensis– an enigmatic developmental programme

Staib

Morschhäuser

2006

Mycoses

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Chlamydospore formation has served for a long time for identification of the human fungal pathogen Candida albicans, but the biological function of these structures still remains a secret. They have been proposed to allow survival in harsh environmental conditions, but this assumption remains to be proven. Chlamydospores are produced only by the two closely related species C. albicans and Candida dubliniensis, whose natural habitats are humans and warm-blooded animals, but not by other Candida species that are also found outside animal hosts. However, no role in the pathogenesis of Candida infections has been assigned to these unusual cells and only a limited number of studies have been conducted in the past to unravel their function. The development of new molecular tools and the recent discovery of mating in C. albicans have also restimulated investigations to understand the morphogenesis and function of chlamydospores. The finding that chlamydospore formation is differentially controlled by certain environmental signals in C. albicans and C. dubliniensis has opened new approaches to study the regulation of this morphogenetic programme. These studies have already identified genes and signalling pathways that are required for chlamydospore production and should lead to a detailed understanding of this fascinating developmental process.

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“…Although various aspects of the properties of chlamydospores have been studied (for examples, see Bakerspigel & Burke 1974;Cassone et al, 1975;Jansons & Nickerson, 1970a, b ;Miller et al, 1974), our understanding of their biological characteristics is still far from satisfactory.…”

Section: Introductionmentioning

confidence: 99%

Production of Contiguously Arranged Chlamydospores in Candida albicans

Akisada¹,

Harada²,

Niimi³

et al. 1983

Microbiology

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Contiguous arrangements of two to three chlamydospores occurred in a clinical isolate of Candida albicans. Time-lapse photography showed that the terminal cell of a cell chain was first transformed into a chlamydospore and such transformation proceeded centripetally to the next cell in the chain. Ultrathin sections revealed that the outermost layer of the three-layered chlamydospore wall was continuous throughout the interconnected spores, with the other layers surrounding each spore separately. Chlamydospore chains were common in this organism.

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A possible function of the chilamydospores of Candida albicans

Cited by 13 publications

References 9 publications

Purification and germination ofCandida albicansandCandida dubliniensischlamydospores cultured in liquid media

Purification and germination ofCandida albicansandCandida dubliniensischlamydospores cultured in liquid media

Chlamydospore formation in Candida albicans and Candida dubliniensis– an enigmatic developmental programme

Production of Contiguously Arranged Chlamydospores in Candida albicans

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