“…Invariant NKT cells are innate T lymphocytes that respond rapidly to glycolipid antigens by secreting copious amounts of Th1, Th2, and Th17 cytokines in response to glycolipids presented by the CD1d molecule on antigen presenting cells (Bendelac et al, 2007, Kronenberg andGapin, 2002). Human decidua contains villous and extravillous trophoblasts that express CD1d, which mediates antigen presentation to iNKT cells (Iwasawa et al, 2012, Jenkinson et al, 1999, Matsumoto et al, 2008, Uemura et al, 2008. Activated decidual iNKT cells secrete IFNγ and GM-CSF, whereas peripheral blood iNKT cells exhibit a Th2 cytokine bias of IL-4 production during pregnancy (Boyson et al, 2002).…”