A possible case of metastatic renal cell carcinoma to the mandible 26 years after nephrectomy

Nakamura, Mariko; Koga, Makoto; Harada, Machiko; Haraguchi, Takahiro; Iwamoto, Osamu; Kusukawa, Jingo

doi:10.5794/jjoms.60.370

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…Twenty-seven patients exhibited bleeding at the first visit or during follow-up, which resulted in death in one case [ 31 ]. Ten patients had difficulty with hemostasis during biopsy or surgery [ 7 , 12 , 13 , 16 , 25 , 27 , 34 , 36 , 39 ]. Three patients underwent preoperative vascular embolization or ligation, which did not lead to complications during surgery [ 9 , 10 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma metastasis to the maxillary bone successfully treated with surgery after vascular embolization: a case report

et al. 2020

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Background Metastasis of renal cell carcinoma to the oral cavity is rare. Renal cell carcinoma metastases are regarded as radioresistant tumors and surgery is recommended. However, since metastatic renal cell carcinoma has poor prognosis and is composed of abundant blood vessels, it is sometimes difficult for clinicians to choose surgical therapy. Here, we report a case of a patient with renal cell carcinoma metastasis to the maxillary bone, which was successfully controlled by surgical therapy after vascular embolization, and provide a detailed literature review regarding the treatments and outcomes of renal cell carcinoma metastasis to the oral cavity. Case presentation An 89-year-old Japanese man presented with an 8 × 8-mm granulomatous tumor with palpable pulsation in the left upper gingiva, which had been clinically suspected as an arteriovenous malformation or neoplastic lesion with rich blood vessels. Our patient had undergone left nephrectomy for clear cell carcinoma 7 years prior. Pulmonary metastasis had appeared 3 years later. After intravascular embolization, our patient underwent tumor resection of the maxilla with little intraoperative blood loss. The tumor was diagnosed on histopathology as a metastasis of clear cell renal cell carcinoma to the maxillary bone. Seventeen months after surgery, he died because of pulmonary metastasis without evidence of recurrence in the oral cavity. Conclusions Our literature review reveals that oral metastatic lesions of renal cancer often exhibit rapid enlargement and cause severe symptoms, such as dysphagia and bleeding. Although oral metastasis of renal cell carcinoma has a poor prognosis due to the presence of concurrent disseminated metastases, surgical therapy may be recommended because of its high local control rate and ability to maintain quality of life. Preoperative vascular embolization is considered to be effective to reduce intraoperative hemorrhage, which leads to safe surgery.

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Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma metastasis to the maxillary bone successfully treated with surgery after vascular embolization: a case report

et al. 2020

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“…Twenty-seven patients exhibited bleeding [8, 10-14, 16, 17, 19, 21-24, 26, 28, 30, 31, 38, 39, 43, 48, 50, 55, 58, 61], which resulted in death in one case [58]. Ten patients reportedly had di culty with hemostasis during biopsy or surgery [10,22,26,38,48,52,61,63,66] .Three patients underwent preoperative vascular embolization or ligation, which did not lead to complications during surgery [15,19,26]. Our experience with the present patient also indicated that preoperative vascular embolization is helpful in preventing massive hemorrhage during surgery for pulsatile oral metastasis of RCC.…”

Section: Discussionmentioning

confidence: 99%

Renal Cell Carcinoma Metastasis to the Maxillary Bone: A Case Report and Review of the Literature

Nishii¹,

Shiba²,

Ohsako³

et al. 2020

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Background: Metastasis of renal cell carcinoma (RCC) to the oral cavity is rare. Given the poor prognosis of metastatic RCC, treatment choice is difficult. Here, we report a case of RCC metastasis to the maxillary bone, and provide a detailed literature review regarding the patient characteristics, treatments and outcomes of RCC metastasis to the oral cavity.Case presentation: An 89-year-old Japanese man presented with an 8 × 8-mm granulomatous tumor with palpable pulsation in the left upper gingiva, which had been clinically suspected as an arteriovenous malformation. The patient had undergone left nephrectomy for clear cell carcinoma 7 years prior. Pulmonary metastasis had appeared 3 years later. The patient underwent tumor resection of the maxilla after intravascular embolization, and the tumor was histopathologically diagnosed as a metastasis of clear cell RCC to the maxillary bone. Seventeen months after surgery, he died because of pulmonary metastasis without evidence of recurrence in the oral cavity.Conclusion: Our literature review reveals that oral metastatic lesions of renal cancer often exhibit rapid enlargement and cause severe symptoms, such as dysphagia and bleeding. Although oral metastasis of RCC has a poor prognosis due to the presence of concurrent disseminated metastases, surgical therapy may be recommended because of its high local control rate and ability to maintain quality of life.

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A possible case of metastatic renal cell carcinoma to the mandible 26 years after nephrectomy

Cited by 2 publications

References 2 publications

Renal cell carcinoma metastasis to the maxillary bone successfully treated with surgery after vascular embolization: a case report

Renal cell carcinoma metastasis to the maxillary bone successfully treated with surgery after vascular embolization: a case report

Renal Cell Carcinoma Metastasis to the Maxillary Bone: A Case Report and Review of the Literature

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