A possible bovine polyomavirus

Coackley, W.; Maker, D.; Smith, Victoria

doi:10.1007/bf01314984

Cited by 18 publications

(11 citation statements)

References 5 publications

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“…Antibodies could also be detected in human sera originating from people who had been in close contact with cattle, for example farmers and veterinarians (Parry & Gardner, 1986). Furthermore, a STMVlike virus was isolated from bovine kidney cell cultures, cultured in the presence of foetal bovine serum (Coackley et al, 1980). Recently, several STMV-like viruses were isolated from calf kidney cell cultures originating from 18 animals born and raised at different geographic locations (Westcott et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

The Complete Nucleotide Sequence of Bovine Polyomavirus

Schuurman

Sol

Noordaa

1990

Journal of General Virology

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The complete sequence of the genome of bovine polyomavirus (BPyV), formerly known as the CK isolate of the stump-tailed macaque virus, is presented. The genomic organization of BPyV is similar to that of the non-rodent polyomaviruses. With a genome size of 4697 bp, BPyV has the smallest polyomavirus genome known so far. When compared to simian virus 40 (SV40), the shortness of the BPyV genome is due mainly to differences in the coding capacity of the BPyV early region. The first exon of the proposed large T antigen encodes only 35 amino acids; also, a coding region corresponding to the C-terminal 64 amino acids of the SV40 large T antigen is absent in BPyV. It is proposed that the nucleotide sequence encompassing the small t antigen coding sequence contains an intron sequence of 71 nucleotides. Together the two exon sequences encode a 124 amino acid protein. We conclude that this may be the first example of a polyomavirus that has a small t antigen which is translated from two exon sequences. The enhancer region of BPyV does not show homology to the SV40 enhancer sequences. An agnogene is present with a coding capacity of 118 amino acid residues. The highest degree of homology to SV40 and PyV is present in the VP1 molecule.

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Section: Introductionmentioning

confidence: 99%

The Complete Nucleotide Sequence of Bovine Polyomavirus

Schuurman

Sol

Noordaa

1990

Journal of General Virology

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“…In 1980, COACKLE¥ et al (1) reported the detection of a polyomavirus, which they called WRSV, in tissue cultures prepared from the kidneys of a healthy newborn colostrum deprived calf. The presence of the virus was discovered when eosinophilie intra-nuelear inclusions were observed in CK coverslip cultures.…”

Section: Discussionmentioning

confidence: 99%

Evidence for a bovine origin of the polyomaviurs detected in foetal rhesus monkey kidney cells, FRhK-4 and -6

Parry

Lucas²,

Richmond

et al. 1983

Archives of Virology

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Rabbit antisera to the stump-tailed macaque polyomavirus (STMV) which had been shown by immunoelectron microscopy and indirect immunofluorescence to react with the polyomavirus found in FRhK-4 cells (FRKV), also gave precipitin lines in counter-immunoelectrophoresis (CIE) and double diffusion in gel (GD) when reacted with FRKV. The reactions in GD showed identity with that of a rabbit antiserum to FRKV. Naturally occurring antibody to FRKV (anti-FRKV) was found by CIE in 48 per cent of 353 cattle, 1/106 pigs and 1/20 goats but not in any of 13 other species including 45 rhesus monkeys and 97 humans. Each of 9 anti-FRKV positive samples from cattle, the goat serum, but not the pig serum gave a line of identity with the rabbit antiserum to FRKV in GD against FRKV. Detection of anti-FRKV in colostrum deprived newborn calves and in commercial foetal calf sera (FBS) indicates that intra-uterine infection of cattle with FRKV may occur. FRKV adapted readily to growth in secondary calf kidney cultures and grew more rapidly and to higher titres than in the FRhK-4 cultures. We conclude that FRKV is probably another strain of STMV and that the natural hosts of these viruses are cattle and not primates. Evidence of intra-uterine infection of cattle implies that infectious FRKV may be present in some FBS and may thus have gained entry into various susceptible cell lines, particularly primate kidney.

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“…Continuous cell lines and cell cultures derived from kidney tissues from various animals, especially monkeys, have been reported to be infected with viruses belonging to the Polyomavirus genus of the Papovaviridae (4,8,15,18,25,28,32). One of these viruses, simian virus 40 (SV40), caused much concern when it was discovered in virus seed stocks and batches of polio vaccine widely used in man between the years 1955 and 1963 (26,28).…”

Section: Introductionmentioning

confidence: 99%

“…More recently a cell line (Vero) derived from kidney tissue of an African green monkey has been shown to be chronically infected with potyomavirus HD, which is identical to STh~ T (11,32). Polyomaviruses have also been found in non-primate cell cultures: in ~ pig kidney cell line PK-15 (t8) and in cells prepared from the kidneys of a newborn calf (4). Neither of these last two viruses has been fully characterised.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of a Polyomavirus in two foetal rhesus monkey kidney cell lines used for the growth of hepatitis A virus

Richmond

Parry

Gardner

1984

Archives of Virology

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Electron microscopy and prolonged incubation of cell cultures have revealed the presence of a papovavirus in two foetal rhesus monkey kidney cell lines, FRhK-4 and FRhK-6, which are used to grow hepatitis A virus. The papovavirus, designated FRKV, was present in culture fluids from both cell lines and in thin sections of FRhK-4 cells. The size of the virus, 47 nm, places FRKV within the Polyomavirus genus. FRKV has been grown in primary human embryo kidney and calf kidney cell cultures. Haemagglutinin has not been demonstrated. Preliminary investigations indicate that FRKV is antigenically identical to or closely related to stump-tailed macaque virus and is not one of the primate polyomaviruses SV40, SA12, BK or JC. FRKV reacts with antibody that occurs in pools of foetal and newborn bovine sera suggesting that the virus might be of bovine origin.

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A possible bovine polyomavirus

Abstract: A virus with the characteristics of a polyomavirus was isolated from tissue cultures prepared from the kidneys of a healthy new-born calf.

Cited by 18 publications

References 5 publications

The Complete Nucleotide Sequence of Bovine Polyomavirus

The Complete Nucleotide Sequence of Bovine Polyomavirus

Evidence for a bovine origin of the polyomaviurs detected in foetal rhesus monkey kidney cells, FRhK-4 and -6

Characterisation of a Polyomavirus in two foetal rhesus monkey kidney cell lines used for the growth of hepatitis A virus

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