A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men

Kutsuma, Ayano; Oshida, Haruki; Suwa, Kaname; Nakajima, Kei

doi:10.1016/j.clinbiochem.2013.10.003

Cited by 12 publications

(10 citation statements)

References 9 publications

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“…However, an association between autoimmune gastritis and NASH was not reported previously. Kutsuma et al reported that overweight Japanese men had low pepsinogen I levels and a low pepsinogen I/II ratio (22). These intriguing findings may be applicable to not only patients with type A gastritis but also those with H. pylori-positive type B gastritis.…”

Section: Discussionmentioning

confidence: 88%

High Prevalence of Autoimmune Gastritis in Patients with Nonalcoholic Steatohepatitis

et al. 2019

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Objective To evaluate the prevalence of autoimmune gastritis in patients with histologically proven nonalcoholic steatohepatitis (NASH). Methods A total of 33 patients with NASH and 143 patients with chronic liver disease (66, 24, 22, 10, 1, and 21 patients with hepatitis C, hepatitis B, autoimmune hepatitis/primary biliary cholangitis, non-B/non-C hepatitis, fatty liver, and alcoholic disease, respectively) who underwent upper gastrointestinal endoscopy between January 2013 and August 2016 were retrospectively assessed to determine the prevalence of autoimmune gastritis. The clinical characteristics of these patients with NASH and autoimmune gastritis were examined, and the clinical characteristic and biomarkers were compared between patients with NASH with and without autoimmune gastritis. Results Six of the 33 patients with NASH (19.4%) were diagnosed with autoimmune gastritis. The prevalence of autoimmune gastritis was higher in patients with NASH than in those with other chronic liver diseases [4/143 (2.8%), p=0.002]. All six patients with NASH and autoimmune gastritis exhibited high serum gastrin levels; five of the patients were positive for anti-parietal cell antibodies, and one was negative for anti-parietal cell antibodies but positive for intrinsic factor antibody. Furthermore, 1 patient presented with iron-deficiency anemia (hemoglobin <11 g/dL), but none developed pernicious anemia. Endocrine cell micronests were found in four patients. Patients with NASH and autoimmune gastritis tended to be older with lower ferritin levels than the other patients. Conclusion The prevalence of NASH with concomitant autoimmune gastritis was high, highlighting the need for upper endoscopy for the diagnosis of autoimmune gastritis and gastric malignancies.

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Section: Discussionmentioning

confidence: 88%

High Prevalence of Autoimmune Gastritis in Patients with Nonalcoholic Steatohepatitis

et al. 2019

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“…These results were in partial agreement with Kutsuma et al finding that serum PGI, but not PGII or PGI/PGII, was significantly reduced across the increasing BMI categories. [ 29 ] It has reported that PGI/II ratio had positive correlation with BMI, that is, lower BMI subjects had lower PGI/II. [ 30 , 31 ] When using PGs to diagnose atrophic gastritis and to analyze the relationship between Hp infection and BMI, it found that BMI was associated with PG levels, but not with Hp infection status.…”

Section: Discussionmentioning

confidence: 99%

Serum pepsinogen II levels are doubled with Helicobacter pylori infection in an asymptomatic population of 40,383 Chinese subjects

Liu

Jiang

et al. 2021

Medicine

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Pepsinogen (PG) I and II are crucial in the gastric digestive processes. This study is to examine the relationship of serum PGI, PGII, and PGI/PGII ratio with Helicobacter pylori (Hp) infection, age, sex, and body mass index (BMI) in subjects in Beijing, China. A total of 40,383 asymptomatic subjects, who underwent medical examination in Beijing Rehabilitation Hospital, were included in this study. Serum PG levels were measured using chemoluminescence techniques. The age, sex, and BMI data were collected, and Hp infection was identified with 13 C-urea breath test. Statistical analysis was conducted with Python, Pandas and Seaborn software. Asymptomatic subjects with Hp infection (Hp+) had a significantly higher level of PGI in the serum (111 ng/mL [median]) than those without Hp infection (Hp−) (94 ng/mL, P < .001). The asymptomatic Hp+ subjects had 2-fold higher PGII levels (7.2 ng/mL) than Hp− subjects (3.2 ng/mL, P < .001). These changes produced significantly lower PGI/II ratio in Hp+ patients than in Hp− subjects (16:30, P < .001). The serum PGI and PGII levels were higher in males than in females (PGI: 104 ng/mL vs 95 ng/mL, PGII: 4.3 ng/mL vs 3.7 ng/mL, both P < .001), PGI/II ratio of males is at 95% of that in females ( P < .001). PGI and PGII levels gradually increased in older people ( P < .001), whereas the PGI/II ratio decreased significantly with age ( P < .001). The levels of the two serum PGs were decreased and the ratio increased when BMI were higher than 28 kg/cm 2 ( P < .05). The levels of serum PGI, especial PGII, were increased by Hp infection, and also influenced by age, sex, and BMI. Therefore, these influencing factors should be considered during clinical practice.

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“…Data regarding the association of PGI/PGII ratio and metabolic and anthropometric parameters are limited; contrary to with our results, two previous studies reported that PGI to PGII ratio was positively correlated with glucose, triacylglycerol, and uric acid levels in healthy subjects, as well as urinary albumin excretion in diabetic patients [ 14 15 ]. Surprisingly, in a recent cross-sectional analysis of 819 apparently healthy men, PGI/PGII ratio were related to both low body weight and obesity [ 34 ]; considering this point of view, it is thought that the association of PG levels with cardiometabolic risk factors is more complicated, and may affected bysome conditions such as active H. pylori infection, obesity, or diabetes.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pyloriStool Antigen Levels and Serological Biomarkers of Gastric Inflammation are Associated with Cardio-Metabolic Risk Factors in Type 2 Diabetic Patients

et al. 2015

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BackgroundHelicobacter pylori infection and subsequent gastric inflammation have been proposed as risk factors for the development of insulin resistance and cardiovascular disease. In this study we assessed the possible association of H. pylori bacterial load, and serum biomarker of gastric inflammation with cardiometabolic risk factors in diabetic patients.MethodsIn this cross-sectional study, 84 H. pylori-infected type 2 diabetic patients were assessed for anthropometrics, biochemical and clinical measurements. Pearson correlation test, linear, and logarithmic regression curve estimation models were used to assess the association of H. pylori stool antigen (HpSAg) levels, and pepsinogen I (PGI) to pepsinogen II (PGII) ratio with fasting serum glucose, insulin, serum lipid and lipoprotein parameters, malondialdehyde, high-sensitive C-reactive protein (hs-CRP), systolic and diastolic blood pressure, body weight, waist circumference and lipid accumulation product (LAP) index.ResultsThe mean age of participants was 54±10 years, and 44% were men. Mean HpSAg levels and PGI/PGII ratio were 0.24±0.23 µg/mL and 9.9±9.0, respectively. Higher HpSAg as well as lower PGI/PGII was correlated with higher anthropometric measures and LAP. A significant negative correlation between PGI/PGII ratio and blood pressure (r=-0.21 and r=-0.22, systolic and diastolic, respectively, P<0.05), serum insulin (r=-0.17, P=0.05), and hs-CRP (r=-0.17, P=0.05) was observed. A significant linear association between PGI/PGII ratio with serum triglycerides (β=-0.24, P<0.05), serum high density lipoprotein cholesterol (HDL-C; β=0.43, P<0.01), and triglycerides/HDL-C ratio (β=-0.28, P<0.05) were observed.ConclusionHigher H. pylori bacterial load and lower PGI/PGII ratio was associated with higher levels of cardiometabolic risk factors in H. pylori infected type 2 diabetic patients.

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A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men

Cited by 12 publications

References 9 publications

High Prevalence of Autoimmune Gastritis in Patients with Nonalcoholic Steatohepatitis

High Prevalence of Autoimmune Gastritis in Patients with Nonalcoholic Steatohepatitis

Serum pepsinogen II levels are doubled with Helicobacter pylori infection in an asymptomatic population of 40,383 Chinese subjects

Helicobacter pyloriStool Antigen Levels and Serological Biomarkers of Gastric Inflammation are Associated with Cardio-Metabolic Risk Factors in Type 2 Diabetic Patients

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