A Possible Association Between Hearing Loss and Zika Virus Infections

Mittal, Rahul; Fifer, Robert C.; Liu, Xue Zhong

doi:10.1001/jamaoto.2017.1798

Cited by 12 publications

(15 citation statements)

References 6 publications

(18 reference statements)

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“…A relation between Zika virus infection and hearing loss was also reported in both infants and adults. Zika virus was found to produce a graded distribution of cellular damage in the cochlea, with the greatest damage in the apex, in a manner similar to cytomegalovirus infection [ 32 , 40 , 41 ].…”

Section: Inner Ear Infectionsmentioning

confidence: 99%

Nanoparticles for the Treatment of Inner Ear Infections

et al. 2021

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The inner ear is sensitive to various infections of viral, bacterial, or fungal origin, which, if left untreated, may lead to hearing loss or progress through the temporal bone and cause intracranial infectious complications. Due to its isolated location, the inner ear is difficult to treat, imposing an acute need for improving current therapeutic approaches. A solution for enhancing antimicrobial treatment performance is the use of nanoparticles. Different inorganic, lipidic, and polymeric-based such particles have been designed, tested, and proven successful in the controlled delivery of medication, improving drug internalization by the targeted cells while reducing the systemic side effects. This paper makes a general presentation of common inner ear infections and therapeutics administration routes, further focusing on newly developed nanoparticle-mediated treatments.

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Section: Inner Ear Infectionsmentioning

confidence: 99%

Nanoparticles for the Treatment of Inner Ear Infections

et al. 2021

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“…A study among 104 infants supposed to be infected with ZIKV in Brazil showed 9% cases affected by hearing loss. Further detailed studies are warranted to unearth the relationship between ZIKV and hearing loss (Mittal et al, 2017). The possibility of vertical transmission of ZIKV is documented in the literature.…”

Section: Zika Fever -Clinical Picture Pathology and Pathogenesismentioning

confidence: 99%

Zika Virus / Zika Fever : A Comprehensive Update

Dhama¹,

Karthik²,

Tiwari³

et al. 2018

JEBAS

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Zika virus (ZIKV) has attracted global attention after its first large-scale outbreak in Pacific, Micronesian island of Yap (Year 2007). The virus spreads rapidly and owes increased virulence than the ZIKV which appeared nearly six decades ago, where it was associated with sporadic cases and mild illness. The World Health Organization declared ZIKA as a "Public Health Emergency of International Concern" due to severe illness and associated several complications such as neurological disorders, autoimmune disorder, fetal anomalies, impaired central nervous system (CNS) of the fetus, microcephaly

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“…12 Nonetheless, due to the neurotropic profile of the Zika virus and to the changes in the CNS resulting from the infection, damages to the central auditory pathways potentially impacting the central auditory development and processing cannot be discarded. [12][13][14] Cortical malformations and neurodevelopmental disorders can alter the maturation development of peripheral and central auditory pathways, such as sound information processing, which, in turn, can also impact language and communication development. [15][16][17] Assessing and monitoring auditory function in children exposed to the Zika virus with several testings might lead to proper diagnosis and early interventions.…”

Section: Introductionmentioning

confidence: 99%

Frequency-Following Response and Auditory Behavior in Children with Prenatal Exposure to the Zika Virus

Hora

Muniz

Griz

et al. 2021

Int Arch Otorhinolaryngol

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Introduction Prenatal exposure to the Zika virus can impair neurodevelopment and cause auditory damage. Objective To analyze the frequency-following response (FFR) and the auditory behavior (with the LittlEars ® questionnaire) of children with and without prenatal exposure to Zika virus infection. Methods A total of 30 children participated in the present study, divided into 3 groups: 10 children with microcephaly and prenatal exposure to the Zika virus; 10 normocephalic children with prenatal exposure to the Zika virus; and 10 children with no evidence of prenatal exposure to the virus. The FFR test was performed with the /da/ syllable. The LittlEars ® questionnaire was used with parents/guardians. Results For the FFR measurements, there was no difference between the groups. The children with exposure to the Zika virus presented a final score in the questionnaire below what is expected from children with normal hearing. A significant difference was observed for the final, semantic, and expressive scores between the group with microcephaly and the other groups. A strong negative correlation was seen between the LittlEars ® questionnaire final score and the FFR measurements for the group with microcephaly when compared with the other groups. Conclusion Children exposed to the Zika virus, with and without microcephaly, presented FFR patterns similar to what was seen in children with no evidence of virus exposure. However, they showed signs of immature auditory behavior, suggesting auditory development delay.

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A Possible Association Between Hearing Loss and Zika Virus Infections

Cited by 12 publications

References 6 publications

Nanoparticles for the Treatment of Inner Ear Infections

Nanoparticles for the Treatment of Inner Ear Infections

Zika Virus / Zika Fever : A Comprehensive Update

Frequency-Following Response and Auditory Behavior in Children with Prenatal Exposure to the Zika Virus

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