A Positron-Emission Transaxial Tomograph for Nuclear Imaging (PETT)

Ter‐Pogossian, Michel M.; Phelps, Michael E.; Hoffman, Edward J.; Mullani, Nizar A.

doi:10.1148/114.1.89

Cited by 575 publications

(194 citation statements)

References 10 publications

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“…Since the first prototypes [1,2] and the first commercial system [3], positron emission tomography (PET) has developed to multiring systems permitting high resolution and three-dimensional imaging of various physiological, functional and molecular targets. The first applications of PET were in brain research, and despite the many other diagnostic indications, particularly in oncology and cardiology, brain imaging remains a stronghold of PET.…”

Section: Introductionmentioning

confidence: 99%

The potential of PET/MR for brain imaging

Heiss

2008

Eur J Nucl Med Mol Imaging

129

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Introduction The completion of an integrated PET/MR prototype system for brain imaging is the latest step in the evolution of positron emission tomography. Early images with this new imaging system demonstrate that highresolution multiparametric studies can be combined without significant loss of performance of either imaging modality. Objective This new technology will make fusion of morphological and biological information much easier, yield real-time assessment of complementary variables and will provide dynamic information for kinetic model- IntroductionSince the first prototypes [1, 2] and the first commercial system [3], positron emission tomography (PET) has developed to multiring systems permitting high resolution and three-dimensional imaging of various physiological, functional and molecular targets. The first applications of PET were in brain research, and despite the many other diagnostic indications, particularly in oncology and cardiology, brain imaging remains a stronghold of PET.Therefore, this discussion of perspectives of an integrated PET/MR system is focused on research applications in neuroscience to which the combination of PET and MRI may add further impetus. This perspective is in parts speculative and it does not include a discussion of the technical or methodological challenges of combined PET/ MR imaging. These aspects are reviewed elsewhere in the articles of this supplement to EJNMMI. Development of PET for brain imagingThe progress in image quality may be followed by metabolic images of glucose consumption in one volunteer acquired on several generation PET systems over the years. The first transaxial image (Fig. 1a) was acquired on a single hexagonal array, the ECAT PET, which covered only the cortical rim. Early PET images suffered from limited spatial resolution (approximately 15 mm), low sensitivity and insufficient attenuation and scatter correction [3,4]. PET image quality improved with the four-ring PC-384 (Scanditronix) [5], which yielded seven simultaneous, partly overlapping transaxial images and that provided a spatial resolution of 8.4 mm FWHM across 12-mm slices (Fig. 1b) [6] and limited axial reconstruction (Fig. 2). Further improvements came with the Eur

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Section: Introductionmentioning

confidence: 99%

The potential of PET/MR for brain imaging

Heiss

2008

Eur J Nucl Med Mol Imaging

129

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“…Already shortly after the introduction of clinical PET scanners, which were based upon the work of Phelps and TerPogossian (Ter-Pogossian et al, 1975), the first geoscientific studies were conducted with PET. Numerous investigations of flow processes in various rock formations have been conducted since 1989 (van den Bergen, 1989;Benton and Parker, 1996;Khalili et al, 1998;Degueldre et al, 1996;Ogilvie et al, 2001;Tenchine and Gouze, 2005;Goethals et al, 2009;Kinsella et al, 2012;Boutchko et al, 2012;Fernø et al, 2015;Gauteplas, 2015;Hoff et al, 1996).…”

Section: Geopet: Applications Of Pet In Geosciencesmentioning

confidence: 99%

Geoscientific process monitoring with positron emission tomography (GeoPET)

et al. 2016

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Abstract. Transport processes in geomaterials can be observed with input-output experiments, which yield no direct information on the impact of heterogeneities, or they can be assessed by model simulations based on structural imaging using µ-CT. Positron emission tomography (PET) provides an alternative experimental observation method which directly and quantitatively yields the spatio-temporal distribution of tracer concentration. Process observation with PET benefits from its extremely high sensitivity together with a resolution that is acceptable in relation to standard drill core sizes. We strongly recommend applying high-resolution PET scanners in order to achieve a resolution on the order of 1 mm.We discuss the particularities of PET applications in geoscientific experiments (GeoPET), which essentially are due to high material density. Although PET is rather insensitive to matrix effects, mass attenuation and Compton scattering have to be corrected thoroughly in order to derive quantitative values.Examples of process monitoring of advection and diffusion processes with GeoPET illustrate the procedure and the experimental conditions, as well as the benefits and limits of the method.

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“…Since the invention of PET in the 1970's [1], resolution has been ever increasing. Our motion tracking method is targeted at the Siemens High Resolution Research Tomograph (HRRT), which features a spatial resolution below 2 mm [2].…”

Section: Introductionmentioning

confidence: 99%

Real Time Surface Registration for PET Motion Tracking

et al. 2011

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Abstract. Head movement during high resolution Positron Emission Tomography brain studies causes blur and artifacts in the images. Therefore, attempts are being made to continuously monitor the pose of the head and correct for this movement. Specifically, our method uses a structured light scanner system to create point clouds representing parts of the patient's face. The movement is estimated by a rigid registration of the point clouds. The registration should be done using a robust algorithm that can handle partial overlap and ideally operate in real time. We present an optimized Iterative Closest Point algorithm that operates at 10 frames per second on partial human face surfaces.

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A Positron-Emission Transaxial Tomograph for Nuclear Imaging (PETT)

Cited by 575 publications

References 10 publications

The potential of PET/MR for brain imaging

The potential of PET/MR for brain imaging

Geoscientific process monitoring with positron emission tomography (GeoPET)

Real Time Surface Registration for PET Motion Tracking

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