Abstract:Extramammary Paget’s disease is recognized as an apocrine-origin cutaneous tumor and is localized in the intraepithelial skin lesion. However, its advanced form is intractable, and there is currently no therapeutic option with a satisfactory level of clinical outcome. Therefore, it is of great importance to identify a potential biomarker to estimate tumor advancement in extramammary Paget’s disease. Dermcidin is an antimicrobial peptide derived from the eccrine gland and is identified as a biomarker in various… Show more
“…Acral melanomas in non-sun-exposed skin, such as planta may be associated with mechanical stress. Ohmori et al show that dermcidin, which is expressed in normal eccrine glands and provides antimicrobial action in sweat, is expressed in Paget cells and is closely associated with a poor prognosis in extramammary Paget diseases [ 4 ]. Moniaga et al review the molecular mechanism of atopic dermatitis.…”
“…Acral melanomas in non-sun-exposed skin, such as planta may be associated with mechanical stress. Ohmori et al show that dermcidin, which is expressed in normal eccrine glands and provides antimicrobial action in sweat, is expressed in Paget cells and is closely associated with a poor prognosis in extramammary Paget diseases [ 4 ]. Moniaga et al review the molecular mechanism of atopic dermatitis.…”
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