A portable three-dimensional photoacoustic tomography system for imaging of chronic foot ulcers

Wang, Yuehang; Zhan, Yang; Harris, Linda M.; Khan, Sikandar Z.; Xia, Jun

doi:10.21037/qims.2019.05.02

Cited by 39 publications

(28 citation statements)

References 29 publications

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“…Chronic skin wounds, resulting from diabetes or occlusive peripheral arterial disease, pose a clinically interesting target [ 118 , 119 ]. Similar to thermal injuries, which have been previously imaged with optoacoustics [ 63 , 64 , 65 ], OAI could help to monitor healing and scar formation, and to guide further surgical interventions.…”

Section: Optoacoustic Imaging Of Inflammation: Applicationsmentioning

confidence: 99%

Optoacoustic Imaging in Inflammation

et al. 2021

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Optoacoustic or photoacoustic imaging (OAI/PAI) is a technology which enables non-invasive visualization of laser-illuminated tissue by the detection of acoustic signals. The combination of “light in” and “sound out” offers unprecedented scalability with a high penetration depth and resolution. The wide range of biomedical applications makes this technology a versatile tool for preclinical and clinical research. Particularly when imaging inflammation, the technology offers advantages over current clinical methods to diagnose, stage, and monitor physiological and pathophysiological processes. This review discusses the clinical perspective of using OAI in the context of imaging inflammation as well as in current and emerging translational applications.

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Section: Optoacoustic Imaging Of Inflammation: Applicationsmentioning

confidence: 99%

Optoacoustic Imaging in Inflammation

et al. 2021

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“…PAI indicated a weaker vascular function in the older group, demonstrating PAI's value in early detection of diabetic foot ulcers. Wang et al reported a portable 3D PAT system that is customized for foot imaging to study the vascular effects of chronic wounds [50]. PAI images acquired from a diabetic patient with toe amputations presented less pronounced vascular and background signals compared to that of a healthy volunteer, signifying inadequate blood perfusion in the former (Figure 2).…”

Section: Wound Imagingmentioning

confidence: 99%

“…Reproduced from ref. [50] 2019, AME Publishing Company under Creative Commons Attribution 4.0 International License…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

Clinical noninvasive imaging and spectroscopic tools for dermatological applications: Review of recent progress

Attia

Dev

et al. 2020

Transl Biophotonics

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Dermatologists mainly entrust visual clinical examinations in conjunction with histopathology for an informed skin condition diagnosis, which is invasive and not adequate to assess skin conditions still present in subcutaneous skin layers. With emerging complementary imaging and spectroscopic technologies currently available, the assessment of skin conditions is more accessible than before. This review article will cover these technologies including: photoacoustic imaging, reflectance confocal microscopy, multiphoton microscopy, optical coherence tomography and confocal Raman spectroscopy. The basic concepts of these technologies and their configurations will be touched on, together with their limitations and future directions. The review article will discuss how these technologies are utilized for cutaneous applications, examining studies accomplished either in vivo on humans or on ex vivo human specimens.

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“…This was based on evidence-based global consensus recommendations on prevention and management of foot problems in diabetes in [6]. There are many medical options for in-vivo assessment of DFU such as the photoacoustic imaging technique [9], positron emission tomography (PET), computed tomography (CT) and functional magnetic resonance imaging (fMRI) [10]. While most of these methods are able to provide the information needed, their limitations are of great concern.…”

Section: Introductionmentioning

confidence: 99%

“…There exists a gap for a non-invasive and dye-free approach to determine microcirculation in human skin tissue [16]. Although recent works attempted to employ photoacoustic imaging for routine examination of the healing of chronic ulcers, these works focused on either blood circulation associated with leaking vessels [9] or quantification of blood oxygenation [17].…”

Section: Introductionmentioning

confidence: 99%

Laser Speckle Integrated Multispectral Imaging System for In-Vivo Assessment of Diabetic Foot Ulcer Healing: A Clinical Study

Philimon

Huong

2021

IEEE Access

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The high prevalence of the world's population diagnosed with diabetes mellitus, with a significant number suffering from diabetic foot ulcer (DFU), has always been a global concern over the years. The rapid rise of this disease in the last decades is deemed increasingly alarming as it has left deleterious effects not only on affected patients but also on the society and nation. This paper aims to develop a reliable diagnostic tool to address the tremendous need for coordinated and efficient DFU management via prediction of transcutaneous oxygen saturation (S t O 2 ) and relative blood perfusion (τ) in the affected limb. This system integrates the use of a multispectral imaging and laser speckle contrast imaging technique for two-dimensional (2D) mapping of tissue oxygen and blood perfusion level in ulcerated foot. Longitudinal study revealed a slightly higher mean S t O 2 and τ level in healed ulcer than in impaired healing, despite the data indicating no statistical significance between these two groups   value 0.05 p   . It was observed that a mean S t O 2 of at least 70 % and τ value of 1.5 (×10 3 ) are necessary during the proliferative phase to ensure progressive healing. Based on these findings, this study concluded that high tissue oxygenation and perfusion levels are pivotal to ensure progressive wound healing. This work provides a rationale for evaluating the healing outcomes of skin grafting procedures in diabetic ulcers based on observation of quantitative changes in blood perfusion and tissue oxygen level during its revascularization phase.INDEX TERMS Biomedical signal processing, diabetic foot ulcer, laser speckle contrast imaging, multispectral imaging.

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A portable three-dimensional photoacoustic tomography system for imaging of chronic foot ulcers

Cited by 39 publications

References 29 publications

Optoacoustic Imaging in Inflammation

Optoacoustic Imaging in Inflammation

Clinical noninvasive imaging and spectroscopic tools for dermatological applications: Review of recent progress

Laser Speckle Integrated Multispectral Imaging System for In-Vivo Assessment of Diabetic Foot Ulcer Healing: A Clinical Study

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