A portable optical diagnostic system for rapid malaria screening

Armani, Andrea M.; Chen, Dongyu; McBirney, Samantha; Kaypaghian, Kristina; Huber, Holly A; Ameri, Hossein

doi:10.1117/12.2506924

Cited by 4 publications

(6 citation statements)

References 21 publications

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“…McBirney and colleagues designed, constructed and validated a portable, reagent-free magneto-optic technology for hemozoin detection [ 76 , 77 ]. This technology uses a 635 nm laser diode that emits in a 500 µL sample to a photodetector and a magnet [ 76 ].…”

Section: Biosensors For Hemozoin-based Malaria Diagnosismentioning

confidence: 99%

“…The difference in the optical spectroscopy signal before and after applying the magnetic field indicates the level of infection [ 76 ]. This device was capable of detecting less than 8.1 ng/mL of β-hematin in 500 µL of whole rabbit blood, equivalent to less than 26 parasites/µL of blood (competitive with the 50–200 parasites/µL and 100–200 of microscopy and RDTs, respectively), and without any labelling [ 76 , 77 ]. Nevertheless, this system requires pre-treatment of the sample with ultrasound for blood lysis and the sample volume (500 µL) is not achievable with a finger prick [ 76 ].…”

Section: Biosensors For Hemozoin-based Malaria Diagnosismentioning

confidence: 99%

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Review of Microdevices for Hemozoin-Based Malaria Detection

et al. 2022

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Despite being preventable and treatable, malaria still puts almost half of the world’s population at risk. Thus, prompt, accurate and sensitive malaria diagnosis is crucial for disease control and elimination. Optical microscopy and immuno-rapid tests are the standard malaria diagnostic methods in the field. However, these are time-consuming and fail to detect low-level parasitemia. Biosensors and lab-on-a-chip devices, as reported to different applications, usually offer high sensitivity, specificity, and ease of use at the point of care. Thus, these can be explored as an alternative for malaria diagnosis. Alongside malaria infection inside the human red blood cells, parasites consume host hemoglobin generating the hemozoin crystal as a by-product. Hemozoin is produced in all parasite species either in symptomatic and asymptomatic individuals. Furthermore, hemozoin crystals are produced as the parasites invade the red blood cells and their content relates to disease progression. Hemozoin is, therefore, a unique indicator of infection, being used as a malaria biomarker. Herein, the so-far developed biosensors and lab-on-a-chip devices aiming for malaria detection by targeting hemozoin as a biomarker are reviewed and discussed to fulfil all the medical demands for malaria management towards elimination.

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Section: Biosensors For Hemozoin-based Malaria Diagnosismentioning

confidence: 99%

Section: Biosensors For Hemozoin-based Malaria Diagnosismentioning

confidence: 99%

Review of Microdevices for Hemozoin-Based Malaria Detection

et al. 2022

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“…Nearly half of world's population lives in malaria-endemic regions, and more than half a million deaths resulting from malaria and its complications are reported each year [88], making it a significant global health problem [89]. Significant achievements have been realized in malarial therapeutic development.…”

Section: Various Nanosensors For Point-of-care Diagnosticsmentioning

confidence: 99%

“…An ideal point-of-care diagnostic device should detect at least 100 parasites/ μ L of blood, which is the threshold for early-stage malaria infection [89]. This area is therefore attracting a lot of research interest, and a few researchers have proposed potential tools for point-of-care malarial diagnostics.…”

Section: Various Nanosensors For Point-of-care Diagnosticsmentioning

confidence: 99%

“…This area is therefore attracting a lot of research interest, and a few researchers have proposed potential tools for point-of-care malarial diagnostics. In one of the reports, a portable optical diagnostic device for malaria was designed by Armani et al [89] using β -hematin. Using the device, the authors demonstrated its potential use in early point-of-care diagnosis of malaria by detecting β -hematin in whole rabbit blood.…”

Section: Various Nanosensors For Point-of-care Diagnosticsmentioning

confidence: 99%

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Current Trends of Nanobiosensors for Point-of-Care Diagnostics

Noah

Ndangili

2019

Journal of Analytical Methods in Chemistry

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In order to provide better-quality health care, it is very important that high standards of health care management are achieved by making timely decisions based on rapid diagnostics, smart data analysis, and informatics analysis. Point-of-care testing ensures fast detection of analytes near to the patients facilitating a better disease diagnosis, monitoring, and management. It also enables quick medical decisions since the diseases can be diagnosed at an early stage which leads to improved health outcomes for the patients enabling them to start early treatment. In the recent past, various potential point-of-care devices have been developed and they are paving the way to next-generation point-of-care testing. Biosensors are very critical components of point-of-care devices since they are directly responsible for the bioanalytical performance of an essay. As such, they have been explored for their prospective point-of-care applications necessary for personalized health care management since they usually estimate the levels of biological markers or any chemical reaction by producing signals mainly associated with the concentration of an analyte and hence can detect disease causing markers such as body fluids. Their high selectivity and sensitivity have allowed for early diagnosis and management of targeted diseases; hence, facilitating timely therapy decisions and combination with nanotechnology can improve assessment of the disease onset and its progression and help to plan for treatment of many diseases. In this review, we explore how nanotechnology has been utilized in the development of nanosensors and the current trends of these nanosensors for point-of-care diagnosis of various diseases.

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Nanotechnology in Malaria Diagnosis

Patel,

Patel

et al. 2023

Infectious Diseases Drug Delivery Systems

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A portable optical diagnostic system for rapid malaria screening

Cited by 4 publications

References 21 publications

Review of Microdevices for Hemozoin-Based Malaria Detection

Review of Microdevices for Hemozoin-Based Malaria Detection

Current Trends of Nanobiosensors for Point-of-Care Diagnostics

Nanotechnology in Malaria Diagnosis

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