A porphyrin-triazatruxene dyad for ratiometric two-photon fluorescent sensing of intracellular viscosity

Wang, Yi; Tong, Lei; Zhang, Jinghui; Gong, Lei; Yang, Yanjie; Ma, Xiuquan; Wen, Yongqiang; Du, Hongwu; Qi, Dongdong; Bian, Yongzhong; Liu, Zhiqiang; Jiang, Jianzhuang

doi:10.1039/d2tb00384h

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Cell micro viscosity plays an important role in various biological processes, such as mass and energy transfer, signal transduction, interaction between biological macromolecules (proteins), active enzymes and cell metabolic rate, etc. [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. Therefore, the design and synthesis of effective fluorescent probes for the determination of cell viscosity is of great significance for the study of cell physiological and pathological processes.…”

Section: Introductionmentioning

confidence: 99%

Theoretical Insights into a Near-Infrared Fluorescent Probe NI-VIS Based on the Organic Molecule for Monitoring Intracellular Viscosity

Peng,

Huang,

Liu

et al. 2023

Molecules

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So many biological functional disorders and diseases, such as atherosclerosis, hypertension, diabetes, Alzheimer’s disease, as well as cell malignancy are closely related with the intracellular viscosity. A safe and effective intracellular viscosity detecting method is desired by the biomedical community. Recently, a novel near-infrared fluorescent probe NI-VIS with a twisting intramolecular charge transfer mechanism was developed. The capability of this probe to visualize the viscosity variation in cirrhotic liver tissues and map the micro viscosity in vivo were testified using an experiment. In this work, the twisting intramolecular charge transfer mechanism and fluorescent properties of the probe NI-VIS were studied in detail under quantum mechanical method. The low energy barrier among the different conformations of the probe indicated the occurrence of twisting intramolecular charge transfer due to the rotation of the aryl group in the probe molecule while within the low viscosity environment. The electronic structure analysis on different probe conformations revealed the electron transfer process of the probe under optical excitation. All these theoretical results could provide insights into understand in greater depth the principles and build highly effective fluorescent probe to monitor the viscosity in biological samples.

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Section: Introductionmentioning

confidence: 99%

Theoretical Insights into a Near-Infrared Fluorescent Probe NI-VIS Based on the Organic Molecule for Monitoring Intracellular Viscosity

Peng,

Huang,

Liu

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

Novel V-shaped D-π-A-π-D two-photon absorption compounds with large Stokes shifts: Synthesis, optical properties, selective detection of cysteine, and imaging in living cells

Feng

Cai

et al. 2023

Dyes and Pigments

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Molecular rotor bearing naphthol hydrazone Schiff base for sensing viscosity changes in solutions and biosystems

Liang,

Pan,

et al. 2024

Dyes and Pigments

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A porphyrin-triazatruxene dyad for ratiometric two-photon fluorescent sensing of intracellular viscosity

Abstract: By combining an electron-rich triazatruxene unit (TAT) to an electron-deficient zinc porphyrin fluorophore (ZnPor) via an ethynyl bridge, a new two-photon fluorescent viscosity rotor (TAT-ZnPor) with typical donor-π-acceptor (D-π-A) electronic...

Cited by 3 publications

References 37 publications

Theoretical Insights into a Near-Infrared Fluorescent Probe NI-VIS Based on the Organic Molecule for Monitoring Intracellular Viscosity

Theoretical Insights into a Near-Infrared Fluorescent Probe NI-VIS Based on the Organic Molecule for Monitoring Intracellular Viscosity

Novel V-shaped D-π-A-π-D two-photon absorption compounds with large Stokes shifts: Synthesis, optical properties, selective detection of cysteine, and imaging in living cells

Molecular rotor bearing naphthol hydrazone Schiff base for sensing viscosity changes in solutions and biosystems

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