2019
DOI: 10.1089/wound.2018.0786
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A Porcine Wound Model ofAcinetobacter baumanniiInfection

Abstract: Objective: To better understand Acinetobacter baumannii pathogenesis and to advance drug discovery against this pathogen, we developed a porcine, full-thickness, excisional, monospecies infection wound model.Approach: The research was facilitated with AB5075, a previously characterized, extensively drug-resistant A. baumannii isolate. The model requires cyclophosphamide-induced neutropenia to establish a skin and soft tissue infection (SSTI) that persists beyond 7 days. Multiple, 12-mm-diameter full-thickness … Show more

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Cited by 20 publications
(25 citation statements)
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References 65 publications
(67 reference statements)
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“…Bacteria are the main cause of the 14 million outpatient and 850,000 inpatient skin and soft-tissue infections (SSTIs) each year [ 33 ]. Members of the ESKAPE ( E nterococcus faecium , S taphylococcus aureus , K lebsiella pneumoniae , A cinetobacter baumannii , P seudomonas aeruginosa , and E nterobacter species) family make up the bulk of SSTIs, with A. baumannii a leading cause of SSTIs that occur within a military environment [ 4 , 31 , 34 ].…”
Section: Introduction To a Baumanniimentioning
confidence: 99%
“…Bacteria are the main cause of the 14 million outpatient and 850,000 inpatient skin and soft-tissue infections (SSTIs) each year [ 33 ]. Members of the ESKAPE ( E nterococcus faecium , S taphylococcus aureus , K lebsiella pneumoniae , A cinetobacter baumannii , P seudomonas aeruginosa , and E nterobacter species) family make up the bulk of SSTIs, with A. baumannii a leading cause of SSTIs that occur within a military environment [ 4 , 31 , 34 ].…”
Section: Introduction To a Baumanniimentioning
confidence: 99%
“…Biofilm formation is an important component of the A. baumannii lifecycle; the bacterium is known to create biofilms on both biotic and abiotic surfaces, which aides in fomite-based transmission and in virulence (Longo et al, 2014;Zurawski et al, 2019). Moreover, biofilms are notorious for their ability to decrease the effectiveness of antibiotic treatment (Hoiby et al, 2010).…”
Section: Biofilms Of Mutant Strains Retain Increased Copper Sensitivitymentioning
confidence: 99%
“…A. baumannii infections are usually very difficult to treat; however, the organism has depicted a relatively low virulence potential in immunocompetent hosts [ 9 ]. However, recently, animal infection models have reported A. baumannii strains with increased pathogenicity [ 10 , 11 ]. This might be due to phenotypic and genetic adaptations that could increase the resistance and virulence potential of A. baumannii [ 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%